Tamoxifen protects photoreceptors in the sodium iodate model

Because the selective estrogen receptor modulator tamoxifen was shown to be retina-protective in the light damage and rd10 models of retinal degeneration, the purpose of this study was to test whether tamoxifen is retina-protective in a model where retinal pigment epithelium (RPE) toxicity appears t...

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Veröffentlicht in:	Experimental eye research 2024-05, Vol.242, p.109879-109879, Article 109879
Hauptverfasser:	Lee, Timothy T., Bell, Brent A., Anderson, Brandon D., Song, Ying, Dunaief, Joshua L.
Format:	Artikel
Sprache:	eng
Schlagworte:	Animals Disease Models, Animal Electroretinography Iodates - toxicity Mice Mice, Inbred C57BL Photoreceptor Cells, Vertebrate - drug effects Photoreceptor Cells, Vertebrate - pathology Real-Time Polymerase Chain Reaction Retinal degeneration Retinal Degeneration - chemically induced Retinal Degeneration - metabolism Retinal Degeneration - pathology Retinal Degeneration - prevention & control Retinal Pigment Epithelium - drug effects Retinal Pigment Epithelium - metabolism Retinal Pigment Epithelium - pathology Retinal protection Rhodopsin - genetics Rhodopsin - metabolism RNA, Messenger - genetics Rod Opsins - metabolism Selective Estrogen Receptor Modulators - pharmacology Sex Sodium iodate Tamoxifen Tamoxifen - pharmacology Tomography, Optical Coherence - methods
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