Central inhibition of HDAC6 re-sensitizes leptin signaling during obesity to induce profound weight loss

Leptin resistance during excess weight gain significantly contributes to the recidivism of obesity to leptin-based pharmacological therapies. The mechanisms underlying the inhibition of leptin receptor (LepR) signaling during obesity are still elusive. Here, we report that histone deacetylase 6 (HDA...

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Veröffentlicht in:	Cell metabolism 2024-04, Vol.36 (4), p.857-876.e10
Hauptverfasser:	Guan, Dongxian, Men, Yuqin, Bartlett, Alexander, Hernández, Mario Andrés Salazar, Xu, Jie, Yi, Xinchi, Li, Hu-song, Kong, Dong, Mazitschek, Ralph, Ozcan, Umut
Format:	Artikel
Sprache:	eng
Schlagworte:	acetylation Animals anti-obesity drug HDAC6 inhibitors Histone Deacetylase 6 Leptin - metabolism leptin receptor leptin resistance Mice obesity Obesity - metabolism obesity treatment Receptors, Leptin - genetics Receptors, Leptin - metabolism translational medicine type 2 diabetes Weight Gain Weight Loss
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