The Bach1/HO-1 pathway regulates oxidative stress and contributes to ferroptosis in doxorubicin-induced cardiomyopathy in H9c2 cells and mice

Doxorubicin (DOX) is one of the most frequently used chemotherapeutic drugs belonging to the class of anthracyclines. However, the cardiotoxic effects of anthracyclines limit their clinical use. Recent studies have suggested that ferroptosis is the main underlying pathogenetic mechanism of DOX-induc...

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Veröffentlicht in:	Archives of toxicology 2024-06, Vol.98 (6), p.1781-1794
Hauptverfasser:	Wang, Yanwei, Qiu, Jingru, Yan, Hua, Zhang, Nan, Gao, Shixuan, Xu, Ning, Wang, Cuiyan, Lou, Haiyan
Format:	Artikel
Sprache:	eng
Schlagworte:	Animals Anthracycline Antibiotics, Antineoplastic - toxicity Antineoplastic drugs Basic-Leucine Zipper Transcription Factors - genetics Basic-Leucine Zipper Transcription Factors - metabolism Biomedical and Life Sciences Biomedicine Cardiomyocytes Cardiomyopathies - chemically induced Cardiomyopathies - metabolism Cardiomyopathy Cardiotoxicity Cell Line Chemotherapy class Cyclohexylamines Doxorubicin Doxorubicin - toxicity drug therapy Environmental Health Ferroptosis Ferroptosis - drug effects Heart heme oxygenase (biliverdin-producing) Heme oxygenase (decyclizing) Heme Oxygenase-1 - genetics Heme Oxygenase-1 - metabolism Homology Inhibitors Lipid peroxidation Lipid Peroxidation - drug effects Lipids Membrane Proteins Mice Mice, Inbred C57BL Mice, Knockout Molecular Toxicology Myocytes, Cardiac - drug effects Myocytes, Cardiac - metabolism Myocytes, Cardiac - pathology Occupational Medicine/Industrial Medicine Oxidative stress Oxidative Stress - drug effects Peroxidation Pharmacology/Toxicology Phenylenediamines Protoporphyrin Protoporphyrins - pharmacology Rats Signal Transduction - drug effects Therapeutic targets zinc
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