Unilateral deep brain stimulation (DBS) of nucleus ventralis intermedius thalami (Vim) for the treatment of post-traumatic tremor in children: a multicentre experience
Purpose Deep brain stimulation (DBS) of nucleus ventralis intermedius thalami (Vim) is a validated technique for the treatment of essential tremor (ET) in adults. Conversely, its use for post traumatic tremor (PTT) and in paediatric patients is still debated. We evaluated the efficacy of Vim-DBS for...
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| Veröffentlicht in: | Child's nervous system 2024-08, Vol.40 (8), p.2457-2464 |
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| creator | Peraio, Simone Mantovani, Giorgio Araceli, Tommaso Mongardi, Lorenzo Noris, Alice Fino, Edoardo Formica, Francesca Piccinini, Luigi Melani, Federico Lenge, Matteo Scalise, Roberta Battini, Roberta Di Rita, Andrea D’Incerti, Ludovico Appleton, Tayler Cavallo, Michele Alessandro Guerrini, Renzo Giordano, Flavio |
| description | Purpose
Deep brain stimulation (DBS) of nucleus ventralis intermedius thalami (Vim) is a validated technique for the treatment of essential tremor (ET) in adults. Conversely, its use for post traumatic tremor (PTT) and in paediatric patients is still debated. We evaluated the efficacy of Vim-DBS for lesional tremor in three paediatric patients with drug-resistant post-traumatic unilateral tremor.
Methods
We retrospectively collected data regarding three patients with unilateral tremor due to severe head injury, with no MRI evidence of basal ganglia lesions. The three patients underwent stereotactic frame-based robot-assisted DBS of Vim contralateral to the tremor side.
Results
Mean follow-up was 48 months (range: 36–60 months). Tremor was reduced in all patients with a better control of voluntary movements and improvement of functional status (mean FIM scale improvement + 7 points). No surgical complications occurred.
Conclusion
Unilateral contralateral DBS of Vim could be efficacious in post-traumatic tremor, even in paediatric patients and should be offered in PTT drug-resistant patients. |
| doi_str_mv | 10.1007/s00381-024-06380-1 |
| format | Article |
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Deep brain stimulation (DBS) of nucleus ventralis intermedius thalami (Vim) is a validated technique for the treatment of essential tremor (ET) in adults. Conversely, its use for post traumatic tremor (PTT) and in paediatric patients is still debated. We evaluated the efficacy of Vim-DBS for lesional tremor in three paediatric patients with drug-resistant post-traumatic unilateral tremor.
Methods
We retrospectively collected data regarding three patients with unilateral tremor due to severe head injury, with no MRI evidence of basal ganglia lesions. The three patients underwent stereotactic frame-based robot-assisted DBS of Vim contralateral to the tremor side.
Results
Mean follow-up was 48 months (range: 36–60 months). Tremor was reduced in all patients with a better control of voluntary movements and improvement of functional status (mean FIM scale improvement + 7 points). No surgical complications occurred.
Conclusion
Unilateral contralateral DBS of Vim could be efficacious in post-traumatic tremor, even in paediatric patients and should be offered in PTT drug-resistant patients.</description><identifier>ISSN: 0256-7040</identifier><identifier>ISSN: 1433-0350</identifier><identifier>EISSN: 1433-0350</identifier><identifier>DOI: 10.1007/s00381-024-06380-1</identifier><identifier>PMID: 38573550</identifier><language>eng</language><publisher>Berlin/Heidelberg: Springer Berlin Heidelberg</publisher><subject>Adolescent ; Child ; Deep Brain Stimulation - methods ; Female ; Humans ; Male ; Medicine ; Medicine & Public Health ; Neurosciences ; Neurosurgery ; Retrospective Studies ; Treatment Outcome ; Tremor - etiology ; Tremor - therapy ; Ventral Thalamic Nuclei</subject><ispartof>Child's nervous system, 2024-08, Vol.40 (8), p.2457-2464</ispartof><rights>The Author(s), under exclusive licence to Springer-Verlag GmbH Germany, part of Springer Nature 2024. Springer Nature or its licensor (e.g. a society or other partner) holds exclusive rights to this article under a publishing agreement with the author(s) or other rightsholder(s); author self-archiving of the accepted manuscript version of this article is solely governed by the terms of such publishing agreement and applicable law.</rights><rights>2024. The Author(s), under exclusive licence to Springer-Verlag GmbH Germany, part of Springer Nature.</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><cites>FETCH-LOGICAL-c298t-73e31333f7d6689bf9ca7f5ca35cc3665062dce5e445f292a21c73b1f3b374a3</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://link.springer.com/content/pdf/10.1007/s00381-024-06380-1$$EPDF$$P50$$Gspringer$$H</linktopdf><linktohtml>$$Uhttps://link.springer.com/10.1007/s00381-024-06380-1$$EHTML$$P50$$Gspringer$$H</linktohtml><link.rule.ids>315,782,786,27933,27934,41497,42566,51328</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/38573550$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Peraio, Simone</creatorcontrib><creatorcontrib>Mantovani, Giorgio</creatorcontrib><creatorcontrib>Araceli, Tommaso</creatorcontrib><creatorcontrib>Mongardi, Lorenzo</creatorcontrib><creatorcontrib>Noris, Alice</creatorcontrib><creatorcontrib>Fino, Edoardo</creatorcontrib><creatorcontrib>Formica, Francesca</creatorcontrib><creatorcontrib>Piccinini, Luigi</creatorcontrib><creatorcontrib>Melani, Federico</creatorcontrib><creatorcontrib>Lenge, Matteo</creatorcontrib><creatorcontrib>Scalise, Roberta</creatorcontrib><creatorcontrib>Battini, Roberta</creatorcontrib><creatorcontrib>Di Rita, Andrea</creatorcontrib><creatorcontrib>D’Incerti, Ludovico</creatorcontrib><creatorcontrib>Appleton, Tayler</creatorcontrib><creatorcontrib>Cavallo, Michele Alessandro</creatorcontrib><creatorcontrib>Guerrini, Renzo</creatorcontrib><creatorcontrib>Giordano, Flavio</creatorcontrib><title>Unilateral deep brain stimulation (DBS) of nucleus ventralis intermedius thalami (Vim) for the treatment of post-traumatic tremor in children: a multicentre experience</title><title>Child's nervous system</title><addtitle>Childs Nerv Syst</addtitle><addtitle>Childs Nerv Syst</addtitle><description>Purpose
Deep brain stimulation (DBS) of nucleus ventralis intermedius thalami (Vim) is a validated technique for the treatment of essential tremor (ET) in adults. Conversely, its use for post traumatic tremor (PTT) and in paediatric patients is still debated. We evaluated the efficacy of Vim-DBS for lesional tremor in three paediatric patients with drug-resistant post-traumatic unilateral tremor.
Methods
We retrospectively collected data regarding three patients with unilateral tremor due to severe head injury, with no MRI evidence of basal ganglia lesions. The three patients underwent stereotactic frame-based robot-assisted DBS of Vim contralateral to the tremor side.
Results
Mean follow-up was 48 months (range: 36–60 months). Tremor was reduced in all patients with a better control of voluntary movements and improvement of functional status (mean FIM scale improvement + 7 points). No surgical complications occurred.
Conclusion
Unilateral contralateral DBS of Vim could be efficacious in post-traumatic tremor, even in paediatric patients and should be offered in PTT drug-resistant patients.</description><subject>Adolescent</subject><subject>Child</subject><subject>Deep Brain Stimulation - methods</subject><subject>Female</subject><subject>Humans</subject><subject>Male</subject><subject>Medicine</subject><subject>Medicine & Public Health</subject><subject>Neurosciences</subject><subject>Neurosurgery</subject><subject>Retrospective Studies</subject><subject>Treatment Outcome</subject><subject>Tremor - etiology</subject><subject>Tremor - therapy</subject><subject>Ventral Thalamic Nuclei</subject><issn>0256-7040</issn><issn>1433-0350</issn><issn>1433-0350</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2024</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNp9Uctu1DAUtRCIDgM_wAJ5OV0ErnPjPNjR8pQqsaCwtRznmrpKnGAnCL6I3-QOU1iysnSe8j1CPFXwXAE0LzIAtqqAsiqgxhYKdU_sVIVYAGq4L3ZQ6rpooIIz8SjnWwCl27J7KM6w1Q1qDTvx63MMo10p2VEORIvskw1R5jVMG-NhjvLw-uLTuZy9jJsbacvyO8WV9SHLENk50RAYXW_saKcgD1_CdC79nBghuSay68SGY8Ay57Vg6zZxsjtyE8u4zt2EcUgUX0oruZfJYwVJ-rFQChQdPRYPvB0zPbl79-L67Zvry_fF1cd3Hy5fXRWu7Nq1aJBQIaJvhrpuu953zjZeO4vaOaxrDXU5ONJUVdqXXWlL5Rrslccem8riXhxOsUuav22UVzOF7GgcbaR5ywYBEaDu-PJ7UZ6kLs05J_JmSWGy6adRYI77mNM-hvcxf_Yxik3P7vK3nu_2z_J3EBbgSZCZil8pmdt5S5G__L_Y3-BFnkg</recordid><startdate>20240801</startdate><enddate>20240801</enddate><creator>Peraio, Simone</creator><creator>Mantovani, Giorgio</creator><creator>Araceli, Tommaso</creator><creator>Mongardi, Lorenzo</creator><creator>Noris, Alice</creator><creator>Fino, Edoardo</creator><creator>Formica, Francesca</creator><creator>Piccinini, Luigi</creator><creator>Melani, Federico</creator><creator>Lenge, Matteo</creator><creator>Scalise, Roberta</creator><creator>Battini, Roberta</creator><creator>Di Rita, Andrea</creator><creator>D’Incerti, Ludovico</creator><creator>Appleton, Tayler</creator><creator>Cavallo, Michele Alessandro</creator><creator>Guerrini, Renzo</creator><creator>Giordano, Flavio</creator><general>Springer Berlin Heidelberg</general><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7X8</scope></search><sort><creationdate>20240801</creationdate><title>Unilateral deep brain stimulation (DBS) of nucleus ventralis intermedius thalami (Vim) for the treatment of post-traumatic tremor in children: a multicentre experience</title><author>Peraio, Simone ; Mantovani, Giorgio ; Araceli, Tommaso ; Mongardi, Lorenzo ; Noris, Alice ; Fino, Edoardo ; Formica, Francesca ; Piccinini, Luigi ; Melani, Federico ; Lenge, Matteo ; Scalise, Roberta ; Battini, Roberta ; Di Rita, Andrea ; D’Incerti, Ludovico ; Appleton, Tayler ; Cavallo, Michele Alessandro ; Guerrini, Renzo ; Giordano, Flavio</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c298t-73e31333f7d6689bf9ca7f5ca35cc3665062dce5e445f292a21c73b1f3b374a3</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2024</creationdate><topic>Adolescent</topic><topic>Child</topic><topic>Deep Brain Stimulation - methods</topic><topic>Female</topic><topic>Humans</topic><topic>Male</topic><topic>Medicine</topic><topic>Medicine & Public Health</topic><topic>Neurosciences</topic><topic>Neurosurgery</topic><topic>Retrospective Studies</topic><topic>Treatment Outcome</topic><topic>Tremor - etiology</topic><topic>Tremor - therapy</topic><topic>Ventral Thalamic Nuclei</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Peraio, Simone</creatorcontrib><creatorcontrib>Mantovani, Giorgio</creatorcontrib><creatorcontrib>Araceli, Tommaso</creatorcontrib><creatorcontrib>Mongardi, Lorenzo</creatorcontrib><creatorcontrib>Noris, Alice</creatorcontrib><creatorcontrib>Fino, Edoardo</creatorcontrib><creatorcontrib>Formica, Francesca</creatorcontrib><creatorcontrib>Piccinini, Luigi</creatorcontrib><creatorcontrib>Melani, Federico</creatorcontrib><creatorcontrib>Lenge, Matteo</creatorcontrib><creatorcontrib>Scalise, Roberta</creatorcontrib><creatorcontrib>Battini, Roberta</creatorcontrib><creatorcontrib>Di Rita, Andrea</creatorcontrib><creatorcontrib>D’Incerti, Ludovico</creatorcontrib><creatorcontrib>Appleton, Tayler</creatorcontrib><creatorcontrib>Cavallo, Michele Alessandro</creatorcontrib><creatorcontrib>Guerrini, Renzo</creatorcontrib><creatorcontrib>Giordano, Flavio</creatorcontrib><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>MEDLINE - Academic</collection><jtitle>Child's nervous system</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Peraio, Simone</au><au>Mantovani, Giorgio</au><au>Araceli, Tommaso</au><au>Mongardi, Lorenzo</au><au>Noris, Alice</au><au>Fino, Edoardo</au><au>Formica, Francesca</au><au>Piccinini, Luigi</au><au>Melani, Federico</au><au>Lenge, Matteo</au><au>Scalise, Roberta</au><au>Battini, Roberta</au><au>Di Rita, Andrea</au><au>D’Incerti, Ludovico</au><au>Appleton, Tayler</au><au>Cavallo, Michele Alessandro</au><au>Guerrini, Renzo</au><au>Giordano, Flavio</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Unilateral deep brain stimulation (DBS) of nucleus ventralis intermedius thalami (Vim) for the treatment of post-traumatic tremor in children: a multicentre experience</atitle><jtitle>Child's nervous system</jtitle><stitle>Childs Nerv Syst</stitle><addtitle>Childs Nerv Syst</addtitle><date>2024-08-01</date><risdate>2024</risdate><volume>40</volume><issue>8</issue><spage>2457</spage><epage>2464</epage><pages>2457-2464</pages><issn>0256-7040</issn><issn>1433-0350</issn><eissn>1433-0350</eissn><abstract>Purpose
Deep brain stimulation (DBS) of nucleus ventralis intermedius thalami (Vim) is a validated technique for the treatment of essential tremor (ET) in adults. Conversely, its use for post traumatic tremor (PTT) and in paediatric patients is still debated. We evaluated the efficacy of Vim-DBS for lesional tremor in three paediatric patients with drug-resistant post-traumatic unilateral tremor.
Methods
We retrospectively collected data regarding three patients with unilateral tremor due to severe head injury, with no MRI evidence of basal ganglia lesions. The three patients underwent stereotactic frame-based robot-assisted DBS of Vim contralateral to the tremor side.
Results
Mean follow-up was 48 months (range: 36–60 months). Tremor was reduced in all patients with a better control of voluntary movements and improvement of functional status (mean FIM scale improvement + 7 points). No surgical complications occurred.
Conclusion
Unilateral contralateral DBS of Vim could be efficacious in post-traumatic tremor, even in paediatric patients and should be offered in PTT drug-resistant patients.</abstract><cop>Berlin/Heidelberg</cop><pub>Springer Berlin Heidelberg</pub><pmid>38573550</pmid><doi>10.1007/s00381-024-06380-1</doi><tpages>8</tpages></addata></record> |
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| identifier | ISSN: 0256-7040 |
| ispartof | Child's nervous system, 2024-08, Vol.40 (8), p.2457-2464 |
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| source | MEDLINE; SpringerNature Journals |
| subjects | Adolescent Child Deep Brain Stimulation - methods Female Humans Male Medicine Medicine & Public Health Neurosciences Neurosurgery Retrospective Studies Treatment Outcome Tremor - etiology Tremor - therapy Ventral Thalamic Nuclei |
| title | Unilateral deep brain stimulation (DBS) of nucleus ventralis intermedius thalami (Vim) for the treatment of post-traumatic tremor in children: a multicentre experience |
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