Design, Synthesis, and In Vivo Evaluation of Isosteviol Derivatives as New SIRT3 Activators with Highly Potent Cardioprotective Effects

Cardiovascular diseases (CVDs) persist as the predominant cause of mortality, urging the exploration of innovative pharmaceuticals. Mitochondrial dysfunction stands as a pivotal contributor to CVDs development. Sirtuin 3 (SIRT3), a prominent mitochondrial deacetylase known for its crucial role in pr...

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Veröffentlicht in:	Journal of medicinal chemistry 2024-04, Vol.67 (8), p.6749-6768
Hauptverfasser:	Chen, Zhenyu, Li, Zhiyin, Xu, Ruilong, Xie, Yufeng, Li, Dehuai, Zhao, Yu
Format:	Artikel
Sprache:	eng
Schlagworte:	Animals Cardiotonic Agents - chemical synthesis Cardiotonic Agents - chemistry Cardiotonic Agents - pharmacology Cardiotonic Agents - therapeutic use Diterpenes, Kaurane - chemical synthesis Diterpenes, Kaurane - chemistry Diterpenes, Kaurane - pharmacology Diterpenes, Kaurane - therapeutic use Doxorubicin - pharmacology Drug Design Humans Mice Myocytes, Cardiac - drug effects Myocytes, Cardiac - metabolism Oxidative Stress - drug effects Sirtuin 3 - antagonists & inhibitors Sirtuin 3 - metabolism Structure-Activity Relationship Zebrafish
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