Synergistic targeting of TrxR1 and ATM/AKT pathway in human colon cancer cells

Thioredoxin reductase 1 (TrxR1) has emerged as a promising target for cancer therapy. In our previous research, we discovered several new TrxR1 inhibitors and found that they all have excellent anti-tumor activity. At the same time, we found these TrxR1 inhibitors all lead to an increase in AKT phos...

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Veröffentlicht in:	Biomedicine & pharmacotherapy 2024-05, Vol.174, p.116507-116507, Article 116507
Hauptverfasser:	Shen, Xin, Xia, Yiqun, Lu, Hui, Zheng, Peisen, Wang, Junqi, Chen, Yinghua, Xu, Chenxin, Qiu, Chenyu, Zhang, Yafei, Xiao, Zhongxiang, Zou, Peng, Cui, Ri, Ni, Daoyong
Format:	Artikel
Sprache:	eng
Schlagworte:	AKT Autophagy Colon cancer ROS TrxR1
Online-Zugang:	Volltext
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