Development of an Imidazopyridazine-Based MNK1/2 Inhibitor for the Treatment of Lymphoma

The mitogen-activated protein kinase-interacting protein kinases (MNKs) are the only kinases known to phosphorylate eukaryotic translation initiation factor 4E (eIF4E) at Ser209, which plays a significant role in cap-dependent translation. Dysregulation of the MNK/eIF4E axis has been found in variou...

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Veröffentlicht in:	Journal of medicinal chemistry 2024-04, Vol.67 (7), p.5437-5457
Hauptverfasser:	Yuan, Xinrui, Guan, Dezhong, Chen, Chao, Guo, Shi, Wu, Hanshu, Bu, Hong, Yang, Chao-Yie, Wang, Mian, Zhou, Jinpei, Zhang, Huibin
Format:	Artikel
Sprache:	eng
Online-Zugang:	Volltext
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