Cytokines-activated nuclear IKKα-FAT10 pathway induces breast cancer tamoxifen-resistance

Endocrine therapy that blocks estrogen signaling is the most effective treatment for patients with estrogen receptor positive (ER + ) breast cancer. However, the efficacy of agents such as tamoxifen (Tam) is often compromised by the development of resistance. Here we report that cytokines-activated...

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Veröffentlicht in:	Science China. Life sciences 2024-07, Vol.67 (7), p.1413-1426
Hauptverfasser:	Chen, Xueyan, Wu, Weilin, Jeong, Ji-Hak, Rokavec, Matjaz, Wei, Rui, Feng, Shaolong, Schroth, Werner, Brauch, Hiltrud, Zhong, Shangwei, Luo, Jun-Li
Format:	Artikel
Sprache:	eng
Schlagworte:	Biomedical and Life Sciences Breast cancer Cytokines Endocrine therapy Estrogen receptors Estrogens Life Sciences Lymphotoxin Metastases Pax5 protein Research Paper Tamoxifen Therapeutic targets
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