Sex dimorphisms in coagulation: Implications in trauma‐induced coagulopathy and trauma resuscitation
Trauma‐induced coagulopathy (TIC) is one of the leading causes of preventable death in injured patients. Consequently, it is imperative to understand the mechanisms underlying TIC and how to mitigate this mortality. An opportunity for advancement stems from the awareness that coagulation demonstrate...
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| Veröffentlicht in: | American journal of hematology 2024-04, Vol.99 (S1), p.S28-S35 |
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| container_title | American journal of hematology |
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| creator | Coleman, Julia R. Gumina, Richard Hund, Thomas Cohen, Mitchell Neal, Matthew D. Townsend, Kristy Kerlin, Bryce A. |
| description | Trauma‐induced coagulopathy (TIC) is one of the leading causes of preventable death in injured patients. Consequently, it is imperative to understand the mechanisms underlying TIC and how to mitigate this mortality. An opportunity for advancement stems from the awareness that coagulation demonstrates a strong sex‐dependent effect. Females exhibit a relative hypercoagulability compared to males, which persists after injury and confers improved outcomes. The mechanisms underlying sex dimorphisms in coagulation and its protective effect after injury have yet to be elucidated. This review explores sex dimorphisms in enzymatic hemostasis, fibrinogen, platelets, and fibrinolysis, with implications for resuscitation of patients with TIC.
Sex dimorphisms in coagulation have significant implications in understanding and treating trauma‐induced coagulopathy. Don't miss this review by Coleman et al. on the clinical implications of sex‐specific differences in hemostatic capacity. |
| doi_str_mv | 10.1002/ajh.27296 |
| format | Article |
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| identifier | ISSN: 0361-8609 |
| ispartof | American journal of hematology, 2024-04, Vol.99 (S1), p.S28-S35 |
| issn | 0361-8609 1096-8652 1096-8652 |
| language | eng |
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| source | Wiley Online Library Journals Frontfile Complete |
| subjects | Coagulation Fibrinogen Fibrinolysis Hemostasis Sex Trauma |
| title | Sex dimorphisms in coagulation: Implications in trauma‐induced coagulopathy and trauma resuscitation |
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