Targeting DUSP5 suppresses malignant phenotypes of BRAF-mutant thyroid cancer cells and improves their response to sorafenib

Purpose The role of dual-specificity phosphatase-5 (DUSP5) in BRAF-mutant thyroid cancers remains unclear. The aims of this study are to investigate the role of DUSP5 in BRAF-mutant thyroid cancer cells, explore its value in the diagnosis and evaluate therapeutic potential of targeting DUSP5 combine...

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Veröffentlicht in:	Endocrine 2024-09, Vol.85 (3), p.1268-1277
Hauptverfasser:	Chen, Pu, Wang, Jianling, Yao, Yao, Qu, Yiping, Ji, Meiju, Hou, Peng
Format:	Artikel
Sprache:	eng
Schlagworte:	Animals Antineoplastic Agents - pharmacology Antineoplastic Agents - therapeutic use Apoptosis Apoptosis - drug effects Cell cycle Cell Line, Tumor Cell migration Cell Movement - drug effects Cell Proliferation - drug effects Diabetes Diagnosis Dual-Specificity Phosphatases - genetics Dual-Specificity Phosphatases - metabolism Endocrinology Female Humanities and Social Sciences Humans Internal Medicine Male Medicine Medicine & Public Health Mice Middle Aged multidisciplinary Mutants Mutation Original Article Phenotype Phenotypes Proto-Oncogene Proteins B-raf - genetics Science Sorafenib - pharmacology Sorafenib - therapeutic use Thyroid cancer Thyroid Neoplasms - drug therapy Thyroid Neoplasms - genetics Thyroid Neoplasms - pathology Western blotting
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