Attention and executive function impairments in obstructive sleep apnea are associated with decreased sleep spindles
Introduction Sleep spindles play a key role in sleep-mediated cognitive processes. Cognitive functions are well-known to be affected in obstructive sleep apnea (OSA). Here, we analyzed attention and executive functions in patients with OSA and investigated the relationship between sleep spindles and...
Gespeichert in:
| Veröffentlicht in: | Acta neurologica Belgica 2024-10, Vol.124 (5), p.1507-1515 |
|---|---|
| Hauptverfasser: | , , |
| Format: | Artikel |
| Sprache: | eng |
| Schlagworte: | |
| Online-Zugang: | Volltext |
| Tags: |
Tag hinzufügen
Keine Tags, Fügen Sie den ersten Tag hinzu!
|
| container_end_page | 1515 |
|---|---|
| container_issue | 5 |
| container_start_page | 1507 |
| container_title | Acta neurologica Belgica |
| container_volume | 124 |
| creator | Kizilkilic, Esra Kochan Karadeniz, Derya Senel, Gulcin Benbir |
| description | Introduction
Sleep spindles play a key role in sleep-mediated cognitive processes. Cognitive functions are well-known to be affected in obstructive sleep apnea (OSA). Here, we analyzed attention and executive functions in patients with OSA and investigated the relationship between sleep spindles and cognitive abilities.
Methods
Sixty patients with OSA (18–65 years, 19 females and 41 males) and a control group (
n
= 41) including age-and sex-matched healthy individuals were consecutively and prospectively enrolled. All participants had a full-night polysomnography, and sleep spindles were analyzed using a semi-automated program. For the evaluation of short-term memory, attention and executive functions, Stroop test, forward and backward digit span tests were applied to all participants upon awakening following polysomnography.
Results
Scores of forward and backward digit span and Stroop tests were worse in OSA patients in compared to those in controls. Mean density of sleep spindles was decreased in OSA patients than those in controls (
p
= 0.044). A positive correlation was found between fast sleep spindle frequency and forward digit span (
r
= 2.222;
p
= 0.038) and backward digit span test scores (
r
= 2,157;
p
= 0.042) in OSA patients. In patients with moderate to severe OSA, sleep spindle density was positively correlated with forward (
r
= 2.323,
p
= 0.029) and backward (
r
= 2.500,
p
= 0.016) DSTs, and the duration of sleep spindles had positive correlation with backward DST (
r
= 2.452,
p
= 0.010).
Conclusion
Our findings demonstrated that the disturbances in sleep spindle characteristics in OSA are associated with the cognitive impairments in attention, short-term memory, and executive functions, especially in patients with moderate to severe OSA. |
| doi_str_mv | 10.1007/s13760-024-02534-9 |
| format | Article |
| fullrecord | <record><control><sourceid>proquest_cross</sourceid><recordid>TN_cdi_proquest_miscellaneous_3031133785</recordid><sourceformat>XML</sourceformat><sourcesystem>PC</sourcesystem><sourcerecordid>3031133785</sourcerecordid><originalsourceid>FETCH-LOGICAL-c298t-3d6d7c5bd691282fb6f319cef39243d06ca594c3f1afa19d37fcbc69b7d31d4d3</originalsourceid><addsrcrecordid>eNp9kEGP1iAQhonRuF_W_QMeDEcvVWBaWo6bjasmm3jRM6EwVTYtrQxV99-LX1ePkkzIDM-8CQ9jL6V4I4Xo35KEXotGqLZWB21jnrCTUq1olDHwlJ0ECNEYIcwFuyK6F_W0WsleP2cXMHQahr47sXJdCqYS18RdChx_od9L_IF82pM_j-OyuZiXChGPia8jlbz7M0Mz4sbdltBxl5E7otVHVzDwn7F84wF9Rke1PUjaYgoz0gv2bHIz4dXjfcm-3L77fPOhufv0_uPN9V3jlRlKA0GH3ndj0EaqQU2jnkAajxMY1UIQ2rvOtB4m6SYnTYB-8qPXZuwDyNAGuGSvj9wtr993pGKXSB7n2SVcd7IgQEqAfugqqg7U55Uo42S3HBeXH6wU9o9wewi3Vbg9C7emLr16zN_HBcO_lb96KwAHQPUpfcVs79c9p_rn_8X-BpxOjnk</addsrcrecordid><sourcetype>Aggregation Database</sourcetype><iscdi>true</iscdi><recordtype>article</recordtype><pqid>3031133785</pqid></control><display><type>article</type><title>Attention and executive function impairments in obstructive sleep apnea are associated with decreased sleep spindles</title><source>MEDLINE</source><source>Springer Nature - Complete Springer Journals</source><creator>Kizilkilic, Esra Kochan ; Karadeniz, Derya ; Senel, Gulcin Benbir</creator><creatorcontrib>Kizilkilic, Esra Kochan ; Karadeniz, Derya ; Senel, Gulcin Benbir</creatorcontrib><description>Introduction
Sleep spindles play a key role in sleep-mediated cognitive processes. Cognitive functions are well-known to be affected in obstructive sleep apnea (OSA). Here, we analyzed attention and executive functions in patients with OSA and investigated the relationship between sleep spindles and cognitive abilities.
Methods
Sixty patients with OSA (18–65 years, 19 females and 41 males) and a control group (
n
= 41) including age-and sex-matched healthy individuals were consecutively and prospectively enrolled. All participants had a full-night polysomnography, and sleep spindles were analyzed using a semi-automated program. For the evaluation of short-term memory, attention and executive functions, Stroop test, forward and backward digit span tests were applied to all participants upon awakening following polysomnography.
Results
Scores of forward and backward digit span and Stroop tests were worse in OSA patients in compared to those in controls. Mean density of sleep spindles was decreased in OSA patients than those in controls (
p
= 0.044). A positive correlation was found between fast sleep spindle frequency and forward digit span (
r
= 2.222;
p
= 0.038) and backward digit span test scores (
r
= 2,157;
p
= 0.042) in OSA patients. In patients with moderate to severe OSA, sleep spindle density was positively correlated with forward (
r
= 2.323,
p
= 0.029) and backward (
r
= 2.500,
p
= 0.016) DSTs, and the duration of sleep spindles had positive correlation with backward DST (
r
= 2.452,
p
= 0.010).
Conclusion
Our findings demonstrated that the disturbances in sleep spindle characteristics in OSA are associated with the cognitive impairments in attention, short-term memory, and executive functions, especially in patients with moderate to severe OSA.</description><identifier>ISSN: 0300-9009</identifier><identifier>ISSN: 2240-2993</identifier><identifier>EISSN: 2240-2993</identifier><identifier>DOI: 10.1007/s13760-024-02534-9</identifier><identifier>PMID: 38563875</identifier><language>eng</language><publisher>Cham: Springer International Publishing</publisher><subject>Adolescent ; Adult ; Aged ; Attention - physiology ; Biomedical and Life Sciences ; Biomedicine ; Cognitive Dysfunction - etiology ; Cognitive Dysfunction - physiopathology ; Electroencephalography ; Executive Function - physiology ; Female ; Humans ; Male ; Medicine/Public Health ; Middle Aged ; Neurology ; Neuropsychological Tests ; Neuroradiology ; Neurosciences ; Original Article ; Polysomnography ; Sleep - physiology ; Sleep Apnea, Obstructive - complications ; Sleep Apnea, Obstructive - physiopathology ; Young Adult</subject><ispartof>Acta neurologica Belgica, 2024-10, Vol.124 (5), p.1507-1515</ispartof><rights>The Author(s) under exclusive licence to Belgian Neurological Society 2024 Springer Nature or its licensor (e.g. a society or other partner) holds exclusive rights to this article under a publishing agreement with the author(s) or other rightsholder(s); author self-archiving of the accepted manuscript version of this article is solely governed by the terms of such publishing agreement and applicable law.</rights><rights>2024. The Author(s) under exclusive licence to Belgian Neurological Society.</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><cites>FETCH-LOGICAL-c298t-3d6d7c5bd691282fb6f319cef39243d06ca594c3f1afa19d37fcbc69b7d31d4d3</cites><orcidid>0000-0002-2623-2710 ; 0000-0003-4585-2840 ; 0000-0003-2139-091X</orcidid></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://link.springer.com/content/pdf/10.1007/s13760-024-02534-9$$EPDF$$P50$$Gspringer$$H</linktopdf><linktohtml>$$Uhttps://link.springer.com/10.1007/s13760-024-02534-9$$EHTML$$P50$$Gspringer$$H</linktohtml><link.rule.ids>314,776,780,27901,27902,41464,42533,51294</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/38563875$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Kizilkilic, Esra Kochan</creatorcontrib><creatorcontrib>Karadeniz, Derya</creatorcontrib><creatorcontrib>Senel, Gulcin Benbir</creatorcontrib><title>Attention and executive function impairments in obstructive sleep apnea are associated with decreased sleep spindles</title><title>Acta neurologica Belgica</title><addtitle>Acta Neurol Belg</addtitle><addtitle>Acta Neurol Belg</addtitle><description>Introduction
Sleep spindles play a key role in sleep-mediated cognitive processes. Cognitive functions are well-known to be affected in obstructive sleep apnea (OSA). Here, we analyzed attention and executive functions in patients with OSA and investigated the relationship between sleep spindles and cognitive abilities.
Methods
Sixty patients with OSA (18–65 years, 19 females and 41 males) and a control group (
n
= 41) including age-and sex-matched healthy individuals were consecutively and prospectively enrolled. All participants had a full-night polysomnography, and sleep spindles were analyzed using a semi-automated program. For the evaluation of short-term memory, attention and executive functions, Stroop test, forward and backward digit span tests were applied to all participants upon awakening following polysomnography.
Results
Scores of forward and backward digit span and Stroop tests were worse in OSA patients in compared to those in controls. Mean density of sleep spindles was decreased in OSA patients than those in controls (
p
= 0.044). A positive correlation was found between fast sleep spindle frequency and forward digit span (
r
= 2.222;
p
= 0.038) and backward digit span test scores (
r
= 2,157;
p
= 0.042) in OSA patients. In patients with moderate to severe OSA, sleep spindle density was positively correlated with forward (
r
= 2.323,
p
= 0.029) and backward (
r
= 2.500,
p
= 0.016) DSTs, and the duration of sleep spindles had positive correlation with backward DST (
r
= 2.452,
p
= 0.010).
Conclusion
Our findings demonstrated that the disturbances in sleep spindle characteristics in OSA are associated with the cognitive impairments in attention, short-term memory, and executive functions, especially in patients with moderate to severe OSA.</description><subject>Adolescent</subject><subject>Adult</subject><subject>Aged</subject><subject>Attention - physiology</subject><subject>Biomedical and Life Sciences</subject><subject>Biomedicine</subject><subject>Cognitive Dysfunction - etiology</subject><subject>Cognitive Dysfunction - physiopathology</subject><subject>Electroencephalography</subject><subject>Executive Function - physiology</subject><subject>Female</subject><subject>Humans</subject><subject>Male</subject><subject>Medicine/Public Health</subject><subject>Middle Aged</subject><subject>Neurology</subject><subject>Neuropsychological Tests</subject><subject>Neuroradiology</subject><subject>Neurosciences</subject><subject>Original Article</subject><subject>Polysomnography</subject><subject>Sleep - physiology</subject><subject>Sleep Apnea, Obstructive - complications</subject><subject>Sleep Apnea, Obstructive - physiopathology</subject><subject>Young Adult</subject><issn>0300-9009</issn><issn>2240-2993</issn><issn>2240-2993</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2024</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNp9kEGP1iAQhonRuF_W_QMeDEcvVWBaWo6bjasmm3jRM6EwVTYtrQxV99-LX1ePkkzIDM-8CQ9jL6V4I4Xo35KEXotGqLZWB21jnrCTUq1olDHwlJ0ECNEYIcwFuyK6F_W0WsleP2cXMHQahr47sXJdCqYS18RdChx_od9L_IF82pM_j-OyuZiXChGPia8jlbz7M0Mz4sbdltBxl5E7otVHVzDwn7F84wF9Rke1PUjaYgoz0gv2bHIz4dXjfcm-3L77fPOhufv0_uPN9V3jlRlKA0GH3ndj0EaqQU2jnkAajxMY1UIQ2rvOtB4m6SYnTYB-8qPXZuwDyNAGuGSvj9wtr993pGKXSB7n2SVcd7IgQEqAfugqqg7U55Uo42S3HBeXH6wU9o9wewi3Vbg9C7emLr16zN_HBcO_lb96KwAHQPUpfcVs79c9p_rn_8X-BpxOjnk</recordid><startdate>20241001</startdate><enddate>20241001</enddate><creator>Kizilkilic, Esra Kochan</creator><creator>Karadeniz, Derya</creator><creator>Senel, Gulcin Benbir</creator><general>Springer International Publishing</general><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7X8</scope><orcidid>https://orcid.org/0000-0002-2623-2710</orcidid><orcidid>https://orcid.org/0000-0003-4585-2840</orcidid><orcidid>https://orcid.org/0000-0003-2139-091X</orcidid></search><sort><creationdate>20241001</creationdate><title>Attention and executive function impairments in obstructive sleep apnea are associated with decreased sleep spindles</title><author>Kizilkilic, Esra Kochan ; Karadeniz, Derya ; Senel, Gulcin Benbir</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c298t-3d6d7c5bd691282fb6f319cef39243d06ca594c3f1afa19d37fcbc69b7d31d4d3</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2024</creationdate><topic>Adolescent</topic><topic>Adult</topic><topic>Aged</topic><topic>Attention - physiology</topic><topic>Biomedical and Life Sciences</topic><topic>Biomedicine</topic><topic>Cognitive Dysfunction - etiology</topic><topic>Cognitive Dysfunction - physiopathology</topic><topic>Electroencephalography</topic><topic>Executive Function - physiology</topic><topic>Female</topic><topic>Humans</topic><topic>Male</topic><topic>Medicine/Public Health</topic><topic>Middle Aged</topic><topic>Neurology</topic><topic>Neuropsychological Tests</topic><topic>Neuroradiology</topic><topic>Neurosciences</topic><topic>Original Article</topic><topic>Polysomnography</topic><topic>Sleep - physiology</topic><topic>Sleep Apnea, Obstructive - complications</topic><topic>Sleep Apnea, Obstructive - physiopathology</topic><topic>Young Adult</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Kizilkilic, Esra Kochan</creatorcontrib><creatorcontrib>Karadeniz, Derya</creatorcontrib><creatorcontrib>Senel, Gulcin Benbir</creatorcontrib><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>MEDLINE - Academic</collection><jtitle>Acta neurologica Belgica</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Kizilkilic, Esra Kochan</au><au>Karadeniz, Derya</au><au>Senel, Gulcin Benbir</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Attention and executive function impairments in obstructive sleep apnea are associated with decreased sleep spindles</atitle><jtitle>Acta neurologica Belgica</jtitle><stitle>Acta Neurol Belg</stitle><addtitle>Acta Neurol Belg</addtitle><date>2024-10-01</date><risdate>2024</risdate><volume>124</volume><issue>5</issue><spage>1507</spage><epage>1515</epage><pages>1507-1515</pages><issn>0300-9009</issn><issn>2240-2993</issn><eissn>2240-2993</eissn><abstract>Introduction
Sleep spindles play a key role in sleep-mediated cognitive processes. Cognitive functions are well-known to be affected in obstructive sleep apnea (OSA). Here, we analyzed attention and executive functions in patients with OSA and investigated the relationship between sleep spindles and cognitive abilities.
Methods
Sixty patients with OSA (18–65 years, 19 females and 41 males) and a control group (
n
= 41) including age-and sex-matched healthy individuals were consecutively and prospectively enrolled. All participants had a full-night polysomnography, and sleep spindles were analyzed using a semi-automated program. For the evaluation of short-term memory, attention and executive functions, Stroop test, forward and backward digit span tests were applied to all participants upon awakening following polysomnography.
Results
Scores of forward and backward digit span and Stroop tests were worse in OSA patients in compared to those in controls. Mean density of sleep spindles was decreased in OSA patients than those in controls (
p
= 0.044). A positive correlation was found between fast sleep spindle frequency and forward digit span (
r
= 2.222;
p
= 0.038) and backward digit span test scores (
r
= 2,157;
p
= 0.042) in OSA patients. In patients with moderate to severe OSA, sleep spindle density was positively correlated with forward (
r
= 2.323,
p
= 0.029) and backward (
r
= 2.500,
p
= 0.016) DSTs, and the duration of sleep spindles had positive correlation with backward DST (
r
= 2.452,
p
= 0.010).
Conclusion
Our findings demonstrated that the disturbances in sleep spindle characteristics in OSA are associated with the cognitive impairments in attention, short-term memory, and executive functions, especially in patients with moderate to severe OSA.</abstract><cop>Cham</cop><pub>Springer International Publishing</pub><pmid>38563875</pmid><doi>10.1007/s13760-024-02534-9</doi><tpages>9</tpages><orcidid>https://orcid.org/0000-0002-2623-2710</orcidid><orcidid>https://orcid.org/0000-0003-4585-2840</orcidid><orcidid>https://orcid.org/0000-0003-2139-091X</orcidid></addata></record> |
| fulltext | fulltext |
| identifier | ISSN: 0300-9009 |
| ispartof | Acta neurologica Belgica, 2024-10, Vol.124 (5), p.1507-1515 |
| issn | 0300-9009 2240-2993 2240-2993 |
| language | eng |
| recordid | cdi_proquest_miscellaneous_3031133785 |
| source | MEDLINE; Springer Nature - Complete Springer Journals |
| subjects | Adolescent Adult Aged Attention - physiology Biomedical and Life Sciences Biomedicine Cognitive Dysfunction - etiology Cognitive Dysfunction - physiopathology Electroencephalography Executive Function - physiology Female Humans Male Medicine/Public Health Middle Aged Neurology Neuropsychological Tests Neuroradiology Neurosciences Original Article Polysomnography Sleep - physiology Sleep Apnea, Obstructive - complications Sleep Apnea, Obstructive - physiopathology Young Adult |
| title | Attention and executive function impairments in obstructive sleep apnea are associated with decreased sleep spindles |
| url | https://sfx.bib-bvb.de/sfx_tum?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&ctx_tim=2025-02-01T17%3A33%3A00IST&url_ver=Z39.88-2004&url_ctx_fmt=infofi/fmt:kev:mtx:ctx&rfr_id=info:sid/primo.exlibrisgroup.com:primo3-Article-proquest_cross&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.atitle=Attention%20and%20executive%20function%20impairments%20in%20obstructive%20sleep%20apnea%20are%20associated%20with%20decreased%20sleep%20spindles&rft.jtitle=Acta%20neurologica%20Belgica&rft.au=Kizilkilic,%20Esra%20Kochan&rft.date=2024-10-01&rft.volume=124&rft.issue=5&rft.spage=1507&rft.epage=1515&rft.pages=1507-1515&rft.issn=0300-9009&rft.eissn=2240-2993&rft_id=info:doi/10.1007/s13760-024-02534-9&rft_dat=%3Cproquest_cross%3E3031133785%3C/proquest_cross%3E%3Curl%3E%3C/url%3E&disable_directlink=true&sfx.directlink=off&sfx.report_link=0&rft_id=info:oai/&rft_pqid=3031133785&rft_id=info:pmid/38563875&rfr_iscdi=true |