Palladium-catalyzed alkynylation of allylic gem -difluorides

Herein, a palladium-catalyzed regioselective alkynylation, esterification, and amination of allylic -difluorides C-F bond activation/transmetallation/β-C elimination or nucleophilic attack has been achieved. This innovative protocol showcases an extensive substrate range and operates efficiently und...

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Veröffentlicht in:	Chemical communications (Cambridge, England) England), 2024-04, Vol.60 (33), p.4471-4474
Hauptverfasser:	Liu, Guo-Ying, Tang, Lu-Ning, Li, Jun-Hua, Yang, Sen, Chen, Ming
Format:	Artikel
Sprache:	eng
Schlagworte:	Amines Arrays Difluorides Esterification Esters Functional groups Palladium Substrates
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creator	Liu, Guo-Ying Tang, Lu-Ning Li, Jun-Hua Yang, Sen Chen, Ming
description	Herein, a palladium-catalyzed regioselective alkynylation, esterification, and amination of allylic -difluorides C-F bond activation/transmetallation/β-C elimination or nucleophilic attack has been achieved. This innovative protocol showcases an extensive substrate range and operates efficiently under mild reaction conditions, resulting in high product yields and -selectivity. Particularly noteworthy is its exceptional tolerance towards a wide array of functional groups. This developed methodology provides effective and convenient routes to access a diverse array of essential fluorinated enynes, esters and amines.
doi_str_mv	10.1039/d4cc01007h
format	Article
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source	Royal Society Of Chemistry Journals; Alma/SFX Local Collection
subjects	Amines Arrays Difluorides Esterification Esters Functional groups Palladium Substrates
title	Palladium-catalyzed alkynylation of allylic gem -difluorides
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