Examination of iatrogenic FDG accumulation after COVID-19 vaccination
Purpose This study aimed to investigate the frequency of COVID-19 vaccine-induced reactive change and potential factors including blood type correlated with increased FDG uptake on positron emission tomography (PET)/computed tomography (CT). Materials and methods We evaluated 284 patients who underw...
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| Veröffentlicht in: | Annals of nuclear medicine 2024-06, Vol.38 (6), p.409-417 |
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| creator | Takahashi, Keiko Manabe, Osamu Shizukuishi, Kazuya Shibata, Hirohumi Kawakami, Hiroki Otsuka, Akira Oyama-Manabe, Noriko |
| description | Purpose
This study aimed to investigate the frequency of COVID-19 vaccine-induced reactive change and potential factors including blood type correlated with increased FDG uptake on positron emission tomography (PET)/computed tomography (CT).
Materials and methods
We evaluated 284 patients who underwent PET/CT between June and September 2021 and had a known history of COVID-19 vaccination. Information on the injection site, vaccine type, and adverse reactions was obtained. We visually assessed the presence or absence of accumulation in the axillary and supraclavicular lymph nodes and the deltoid muscles. We measured the maximum standardized uptake value (SUVmax) using semi-quantitative analysis.
Results
Our study included 158 males and 126 females aged 16–94. The median time between vaccination and PET/CT was 9 and 42 days for patients who had received their first and second doses, respectively. We observed axillary lymph node accumulation, supraclavicular lymph node accumulation, and deltoid muscle accumulation in 98 (SUVmax 1.07–25.1), nine (SUVmax 2.28–14.5), and 33 cases (SUVmax 0.93–7.42), respectively. In cases with axillary lymph node (
P
= 0.0057) or deltoid muscle (
P
= 0.047) accumulation, the shorter the time since vaccination, the higher the FDG accumulation. Patients with axillary lymph node accumulation were significantly younger (
P
|
| doi_str_mv | 10.1007/s12149-024-01909-5 |
| format | Article |
| fullrecord | <record><control><sourceid>proquest_cross</sourceid><recordid>TN_cdi_proquest_miscellaneous_3031133732</recordid><sourceformat>XML</sourceformat><sourcesystem>PC</sourcesystem><sourcerecordid>3057773705</sourcerecordid><originalsourceid>FETCH-LOGICAL-c326t-97cb917c399c18d4218b284d1dc788a466762ef45a0416d6819eb0614e207e803</originalsourceid><addsrcrecordid>eNp9kDtPwzAUhS0EgvL4AwwoEguL4V7b8WNEbXlISF2A1XIdpwpqErATBP-eQApIDEweznfOtT5CjhHOEUBdJGQoDAUmKKABQ_MtMkEtBZWC820yAYOCKtRqj-yn9ATAdK7ZLtnjOpdcG5iQ-fzN1VXjuqptsrbMKtfFdhWaymdXs-vMed_X_XqMXdmFmE0Xj7cziiZ7HcJN85DslG6dwtHmPSAPV_P76Q29W1zfTi_vqOdMdtQovzSoPDfGoy4EQ71kWhRYeKW1E1IqyUIpcgcCZSE1mrAEiSIwUEEDPyBn4-5zbF_6kDpbV8mH9do1oe2T5cAROVecDejpH_Sp7WMz_G6gcqUUV5APFBspH9uUYijtc6xqF98tgv2UbEfJdpBsvyTbz9LJZrpf1qH4qXxbHQA-AmmImlWIv7f_mf0ApsCECA</addsrcrecordid><sourcetype>Aggregation Database</sourcetype><iscdi>true</iscdi><recordtype>article</recordtype><pqid>3057773705</pqid></control><display><type>article</type><title>Examination of iatrogenic FDG accumulation after COVID-19 vaccination</title><source>MEDLINE</source><source>SpringerLink Journals</source><creator>Takahashi, Keiko ; Manabe, Osamu ; Shizukuishi, Kazuya ; Shibata, Hirohumi ; Kawakami, Hiroki ; Otsuka, Akira ; Oyama-Manabe, Noriko</creator><creatorcontrib>Takahashi, Keiko ; Manabe, Osamu ; Shizukuishi, Kazuya ; Shibata, Hirohumi ; Kawakami, Hiroki ; Otsuka, Akira ; Oyama-Manabe, Noriko</creatorcontrib><description>Purpose
This study aimed to investigate the frequency of COVID-19 vaccine-induced reactive change and potential factors including blood type correlated with increased FDG uptake on positron emission tomography (PET)/computed tomography (CT).
Materials and methods
We evaluated 284 patients who underwent PET/CT between June and September 2021 and had a known history of COVID-19 vaccination. Information on the injection site, vaccine type, and adverse reactions was obtained. We visually assessed the presence or absence of accumulation in the axillary and supraclavicular lymph nodes and the deltoid muscles. We measured the maximum standardized uptake value (SUVmax) using semi-quantitative analysis.
Results
Our study included 158 males and 126 females aged 16–94. The median time between vaccination and PET/CT was 9 and 42 days for patients who had received their first and second doses, respectively. We observed axillary lymph node accumulation, supraclavicular lymph node accumulation, and deltoid muscle accumulation in 98 (SUVmax 1.07–25.1), nine (SUVmax 2.28–14.5), and 33 cases (SUVmax 0.93–7.42), respectively. In cases with axillary lymph node (
P
= 0.0057) or deltoid muscle (
P
= 0.047) accumulation, the shorter the time since vaccination, the higher the FDG accumulation. Patients with axillary lymph node accumulation were significantly younger (
P
< 0.0001) and had a significantly higher frequency of adverse reactions such as fever (
P
< 0.0001) and myalgia (
P
= 0.002). No significant relationship was observed between blood type and the frequency of FDG accumulation. Logistic regression analysis also showed that age, gender, days since vaccination, and adverse reactions such as fever and myalgia were important factors for axillary lymph node accumulation.
Conclusion
Our study found that FDG accumulation in the axillary lymph nodes and deltoid muscle was higher within a shorter time after vaccination, and axillary lymph node accumulation was higher in young patients, females, and those with adverse reactions of fever and myalgia. No significant relationship was observed between blood type and the frequency of FDG accumulation. Confirming the vaccination status, time since vaccination, and the presence of adverse reactions before PET may reduce false positives.</description><identifier>ISSN: 0914-7187</identifier><identifier>ISSN: 1864-6433</identifier><identifier>EISSN: 1864-6433</identifier><identifier>DOI: 10.1007/s12149-024-01909-5</identifier><identifier>PMID: 38563890</identifier><language>eng</language><publisher>Singapore: Springer Nature Singapore</publisher><subject>Accumulation ; Adolescent ; Adult ; Aged ; Aged, 80 and over ; Blood ; Blood groups ; Clavicle ; Computed tomography ; COVID-19 vaccines ; COVID-19 Vaccines - adverse effects ; Female ; Females ; Fever ; Fluorodeoxyglucose F18 ; Humans ; Iatrogenic Disease ; Imaging ; Immunization ; Lymph nodes ; Lymph Nodes - diagnostic imaging ; Lymphatic system ; Male ; Medicine ; Medicine & Public Health ; Middle Aged ; Muscles ; Myalgia ; Nuclear Medicine ; Original Article ; Positron emission ; Positron emission tomography ; Positron Emission Tomography Computed Tomography ; Radiology ; Regression analysis ; Retrospective Studies ; Side effects ; Tomography ; Vaccination - adverse effects ; Vaccines ; Young Adult</subject><ispartof>Annals of nuclear medicine, 2024-06, Vol.38 (6), p.409-417</ispartof><rights>The Author(s), under exclusive licence to The Author(s) under exclusive licence to The Japanese Society of Nuclear Medicine 2024. corrected publication 2024. Springer Nature or its licensor (e.g. a society or other partner) holds exclusive rights to this article under a publishing agreement with the author(s) or other rightsholder(s); author self-archiving of the accepted manuscript version of this article is solely governed by the terms of such publishing agreement and applicable law.</rights><rights>2024. The Author(s), under exclusive licence to The Author(s) under exclusive licence to The Japanese Society of Nuclear Medicine.</rights><rights>The Author(s), under exclusive licence to The Author(s) under exclusive licence to The Japanese Society of Nuclear Medicine 2024. corrected publication 2024. Springer Nature or its licensor (e.g. a society or other partner) holds exclusive rights to this article under a publishing agreement with the author(s) or other rightsholder(s); author self-archiving of the accepted manuscript version of this article is solely governed by the terms of such publishing agreement and applicable law.</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><cites>FETCH-LOGICAL-c326t-97cb917c399c18d4218b284d1dc788a466762ef45a0416d6819eb0614e207e803</cites><orcidid>0000-0001-8518-8441</orcidid></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://link.springer.com/content/pdf/10.1007/s12149-024-01909-5$$EPDF$$P50$$Gspringer$$H</linktopdf><linktohtml>$$Uhttps://link.springer.com/10.1007/s12149-024-01909-5$$EHTML$$P50$$Gspringer$$H</linktohtml><link.rule.ids>314,776,780,27903,27904,41467,42536,51297</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/38563890$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Takahashi, Keiko</creatorcontrib><creatorcontrib>Manabe, Osamu</creatorcontrib><creatorcontrib>Shizukuishi, Kazuya</creatorcontrib><creatorcontrib>Shibata, Hirohumi</creatorcontrib><creatorcontrib>Kawakami, Hiroki</creatorcontrib><creatorcontrib>Otsuka, Akira</creatorcontrib><creatorcontrib>Oyama-Manabe, Noriko</creatorcontrib><title>Examination of iatrogenic FDG accumulation after COVID-19 vaccination</title><title>Annals of nuclear medicine</title><addtitle>Ann Nucl Med</addtitle><addtitle>Ann Nucl Med</addtitle><description>Purpose
This study aimed to investigate the frequency of COVID-19 vaccine-induced reactive change and potential factors including blood type correlated with increased FDG uptake on positron emission tomography (PET)/computed tomography (CT).
Materials and methods
We evaluated 284 patients who underwent PET/CT between June and September 2021 and had a known history of COVID-19 vaccination. Information on the injection site, vaccine type, and adverse reactions was obtained. We visually assessed the presence or absence of accumulation in the axillary and supraclavicular lymph nodes and the deltoid muscles. We measured the maximum standardized uptake value (SUVmax) using semi-quantitative analysis.
Results
Our study included 158 males and 126 females aged 16–94. The median time between vaccination and PET/CT was 9 and 42 days for patients who had received their first and second doses, respectively. We observed axillary lymph node accumulation, supraclavicular lymph node accumulation, and deltoid muscle accumulation in 98 (SUVmax 1.07–25.1), nine (SUVmax 2.28–14.5), and 33 cases (SUVmax 0.93–7.42), respectively. In cases with axillary lymph node (
P
= 0.0057) or deltoid muscle (
P
= 0.047) accumulation, the shorter the time since vaccination, the higher the FDG accumulation. Patients with axillary lymph node accumulation were significantly younger (
P
< 0.0001) and had a significantly higher frequency of adverse reactions such as fever (
P
< 0.0001) and myalgia (
P
= 0.002). No significant relationship was observed between blood type and the frequency of FDG accumulation. Logistic regression analysis also showed that age, gender, days since vaccination, and adverse reactions such as fever and myalgia were important factors for axillary lymph node accumulation.
Conclusion
Our study found that FDG accumulation in the axillary lymph nodes and deltoid muscle was higher within a shorter time after vaccination, and axillary lymph node accumulation was higher in young patients, females, and those with adverse reactions of fever and myalgia. No significant relationship was observed between blood type and the frequency of FDG accumulation. Confirming the vaccination status, time since vaccination, and the presence of adverse reactions before PET may reduce false positives.</description><subject>Accumulation</subject><subject>Adolescent</subject><subject>Adult</subject><subject>Aged</subject><subject>Aged, 80 and over</subject><subject>Blood</subject><subject>Blood groups</subject><subject>Clavicle</subject><subject>Computed tomography</subject><subject>COVID-19 vaccines</subject><subject>COVID-19 Vaccines - adverse effects</subject><subject>Female</subject><subject>Females</subject><subject>Fever</subject><subject>Fluorodeoxyglucose F18</subject><subject>Humans</subject><subject>Iatrogenic Disease</subject><subject>Imaging</subject><subject>Immunization</subject><subject>Lymph nodes</subject><subject>Lymph Nodes - diagnostic imaging</subject><subject>Lymphatic system</subject><subject>Male</subject><subject>Medicine</subject><subject>Medicine & Public Health</subject><subject>Middle Aged</subject><subject>Muscles</subject><subject>Myalgia</subject><subject>Nuclear Medicine</subject><subject>Original Article</subject><subject>Positron emission</subject><subject>Positron emission tomography</subject><subject>Positron Emission Tomography Computed Tomography</subject><subject>Radiology</subject><subject>Regression analysis</subject><subject>Retrospective Studies</subject><subject>Side effects</subject><subject>Tomography</subject><subject>Vaccination - adverse effects</subject><subject>Vaccines</subject><subject>Young Adult</subject><issn>0914-7187</issn><issn>1864-6433</issn><issn>1864-6433</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2024</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNp9kDtPwzAUhS0EgvL4AwwoEguL4V7b8WNEbXlISF2A1XIdpwpqErATBP-eQApIDEweznfOtT5CjhHOEUBdJGQoDAUmKKABQ_MtMkEtBZWC820yAYOCKtRqj-yn9ATAdK7ZLtnjOpdcG5iQ-fzN1VXjuqptsrbMKtfFdhWaymdXs-vMed_X_XqMXdmFmE0Xj7cziiZ7HcJN85DslG6dwtHmPSAPV_P76Q29W1zfTi_vqOdMdtQovzSoPDfGoy4EQ71kWhRYeKW1E1IqyUIpcgcCZSE1mrAEiSIwUEEDPyBn4-5zbF_6kDpbV8mH9do1oe2T5cAROVecDejpH_Sp7WMz_G6gcqUUV5APFBspH9uUYijtc6xqF98tgv2UbEfJdpBsvyTbz9LJZrpf1qH4qXxbHQA-AmmImlWIv7f_mf0ApsCECA</recordid><startdate>20240601</startdate><enddate>20240601</enddate><creator>Takahashi, Keiko</creator><creator>Manabe, Osamu</creator><creator>Shizukuishi, Kazuya</creator><creator>Shibata, Hirohumi</creator><creator>Kawakami, Hiroki</creator><creator>Otsuka, Akira</creator><creator>Oyama-Manabe, Noriko</creator><general>Springer Nature Singapore</general><general>Springer Nature B.V</general><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7QP</scope><scope>7TK</scope><scope>K9.</scope><scope>NAPCQ</scope><scope>7X8</scope><orcidid>https://orcid.org/0000-0001-8518-8441</orcidid></search><sort><creationdate>20240601</creationdate><title>Examination of iatrogenic FDG accumulation after COVID-19 vaccination</title><author>Takahashi, Keiko ; Manabe, Osamu ; Shizukuishi, Kazuya ; Shibata, Hirohumi ; Kawakami, Hiroki ; Otsuka, Akira ; Oyama-Manabe, Noriko</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c326t-97cb917c399c18d4218b284d1dc788a466762ef45a0416d6819eb0614e207e803</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2024</creationdate><topic>Accumulation</topic><topic>Adolescent</topic><topic>Adult</topic><topic>Aged</topic><topic>Aged, 80 and over</topic><topic>Blood</topic><topic>Blood groups</topic><topic>Clavicle</topic><topic>Computed tomography</topic><topic>COVID-19 vaccines</topic><topic>COVID-19 Vaccines - adverse effects</topic><topic>Female</topic><topic>Females</topic><topic>Fever</topic><topic>Fluorodeoxyglucose F18</topic><topic>Humans</topic><topic>Iatrogenic Disease</topic><topic>Imaging</topic><topic>Immunization</topic><topic>Lymph nodes</topic><topic>Lymph Nodes - diagnostic imaging</topic><topic>Lymphatic system</topic><topic>Male</topic><topic>Medicine</topic><topic>Medicine & Public Health</topic><topic>Middle Aged</topic><topic>Muscles</topic><topic>Myalgia</topic><topic>Nuclear Medicine</topic><topic>Original Article</topic><topic>Positron emission</topic><topic>Positron emission tomography</topic><topic>Positron Emission Tomography Computed Tomography</topic><topic>Radiology</topic><topic>Regression analysis</topic><topic>Retrospective Studies</topic><topic>Side effects</topic><topic>Tomography</topic><topic>Vaccination - adverse effects</topic><topic>Vaccines</topic><topic>Young Adult</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Takahashi, Keiko</creatorcontrib><creatorcontrib>Manabe, Osamu</creatorcontrib><creatorcontrib>Shizukuishi, Kazuya</creatorcontrib><creatorcontrib>Shibata, Hirohumi</creatorcontrib><creatorcontrib>Kawakami, Hiroki</creatorcontrib><creatorcontrib>Otsuka, Akira</creatorcontrib><creatorcontrib>Oyama-Manabe, Noriko</creatorcontrib><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>Calcium & Calcified Tissue Abstracts</collection><collection>Neurosciences Abstracts</collection><collection>ProQuest Health & Medical Complete (Alumni)</collection><collection>Nursing & Allied Health Premium</collection><collection>MEDLINE - Academic</collection><jtitle>Annals of nuclear medicine</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Takahashi, Keiko</au><au>Manabe, Osamu</au><au>Shizukuishi, Kazuya</au><au>Shibata, Hirohumi</au><au>Kawakami, Hiroki</au><au>Otsuka, Akira</au><au>Oyama-Manabe, Noriko</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Examination of iatrogenic FDG accumulation after COVID-19 vaccination</atitle><jtitle>Annals of nuclear medicine</jtitle><stitle>Ann Nucl Med</stitle><addtitle>Ann Nucl Med</addtitle><date>2024-06-01</date><risdate>2024</risdate><volume>38</volume><issue>6</issue><spage>409</spage><epage>417</epage><pages>409-417</pages><issn>0914-7187</issn><issn>1864-6433</issn><eissn>1864-6433</eissn><abstract>Purpose
This study aimed to investigate the frequency of COVID-19 vaccine-induced reactive change and potential factors including blood type correlated with increased FDG uptake on positron emission tomography (PET)/computed tomography (CT).
Materials and methods
We evaluated 284 patients who underwent PET/CT between June and September 2021 and had a known history of COVID-19 vaccination. Information on the injection site, vaccine type, and adverse reactions was obtained. We visually assessed the presence or absence of accumulation in the axillary and supraclavicular lymph nodes and the deltoid muscles. We measured the maximum standardized uptake value (SUVmax) using semi-quantitative analysis.
Results
Our study included 158 males and 126 females aged 16–94. The median time between vaccination and PET/CT was 9 and 42 days for patients who had received their first and second doses, respectively. We observed axillary lymph node accumulation, supraclavicular lymph node accumulation, and deltoid muscle accumulation in 98 (SUVmax 1.07–25.1), nine (SUVmax 2.28–14.5), and 33 cases (SUVmax 0.93–7.42), respectively. In cases with axillary lymph node (
P
= 0.0057) or deltoid muscle (
P
= 0.047) accumulation, the shorter the time since vaccination, the higher the FDG accumulation. Patients with axillary lymph node accumulation were significantly younger (
P
< 0.0001) and had a significantly higher frequency of adverse reactions such as fever (
P
< 0.0001) and myalgia (
P
= 0.002). No significant relationship was observed between blood type and the frequency of FDG accumulation. Logistic regression analysis also showed that age, gender, days since vaccination, and adverse reactions such as fever and myalgia were important factors for axillary lymph node accumulation.
Conclusion
Our study found that FDG accumulation in the axillary lymph nodes and deltoid muscle was higher within a shorter time after vaccination, and axillary lymph node accumulation was higher in young patients, females, and those with adverse reactions of fever and myalgia. No significant relationship was observed between blood type and the frequency of FDG accumulation. Confirming the vaccination status, time since vaccination, and the presence of adverse reactions before PET may reduce false positives.</abstract><cop>Singapore</cop><pub>Springer Nature Singapore</pub><pmid>38563890</pmid><doi>10.1007/s12149-024-01909-5</doi><tpages>9</tpages><orcidid>https://orcid.org/0000-0001-8518-8441</orcidid></addata></record> |
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| ispartof | Annals of nuclear medicine, 2024-06, Vol.38 (6), p.409-417 |
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| language | eng |
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| source | MEDLINE; SpringerLink Journals |
| subjects | Accumulation Adolescent Adult Aged Aged, 80 and over Blood Blood groups Clavicle Computed tomography COVID-19 vaccines COVID-19 Vaccines - adverse effects Female Females Fever Fluorodeoxyglucose F18 Humans Iatrogenic Disease Imaging Immunization Lymph nodes Lymph Nodes - diagnostic imaging Lymphatic system Male Medicine Medicine & Public Health Middle Aged Muscles Myalgia Nuclear Medicine Original Article Positron emission Positron emission tomography Positron Emission Tomography Computed Tomography Radiology Regression analysis Retrospective Studies Side effects Tomography Vaccination - adverse effects Vaccines Young Adult |
| title | Examination of iatrogenic FDG accumulation after COVID-19 vaccination |
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