Diabetic Neuropathy: Pathophysiology Review
Purpose of Review Diabetic neuropathy is a debilitating complication of diabetes mellitus that affects millions of individuals worldwide. It is characterized by nerve damage resulting from prolonged exposure to high blood glucose levels. Diabetic neuropathy may cause a range of symptoms, including p...
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Veröffentlicht in: | Current pain and headache reports 2024-06, Vol.28 (6), p.481-487 |
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description | Purpose of Review
Diabetic neuropathy is a debilitating complication of diabetes mellitus that affects millions of individuals worldwide. It is characterized by nerve damage resulting from prolonged exposure to high blood glucose levels. Diabetic neuropathy may cause a range of symptoms, including pain, numbness, muscle weakness, autonomic dysfunction, and foot ulcers, potentially causing significant impairment to the quality of life for those affected. This review article aims to provide a comprehensive overview of the pathophysiology of diabetic neuropathy. The etiology of diabetic neuropathy will be discussed, including risk factors, predisposing conditions, and an overview of the complex interplay between hyperglycemia, metabolic dysregulation, and nerve damage. Additionally, we will explore the molecular mechanisms and pathways of diabetic neuropathy, including the impact of hyperglycemia on nerve function, abnormalities in glucose metabolism, the role of advanced glycation end products (AGEs), and inflammatory and immune-mediated processes. We will provide an overview of the various nerve fibers affected by diabetic neuropathy and explore the common symptoms and complications associated with diabetic neuropathy in the pain medicine field.
Recent Findings
This review highlights advances in understanding the pathophysiology of diabetic neuropathy as well as reviews potential novel therapeutic strategies and promising areas for future research.
Summary
In conclusion, this review article aims to shed light on the pathophysiology of diabetic neuropathy, its far-reaching consequences, and the evolving strategies for prevention and management. In understanding the mechanisms of diabetic neuropathy and the ongoing research in this area, healthcare professionals can better serve patients with diabetes, ultimately improving well-being and reducing complications. |
doi_str_mv | 10.1007/s11916-024-01243-5 |
format | Article |
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Diabetic neuropathy is a debilitating complication of diabetes mellitus that affects millions of individuals worldwide. It is characterized by nerve damage resulting from prolonged exposure to high blood glucose levels. Diabetic neuropathy may cause a range of symptoms, including pain, numbness, muscle weakness, autonomic dysfunction, and foot ulcers, potentially causing significant impairment to the quality of life for those affected. This review article aims to provide a comprehensive overview of the pathophysiology of diabetic neuropathy. The etiology of diabetic neuropathy will be discussed, including risk factors, predisposing conditions, and an overview of the complex interplay between hyperglycemia, metabolic dysregulation, and nerve damage. Additionally, we will explore the molecular mechanisms and pathways of diabetic neuropathy, including the impact of hyperglycemia on nerve function, abnormalities in glucose metabolism, the role of advanced glycation end products (AGEs), and inflammatory and immune-mediated processes. We will provide an overview of the various nerve fibers affected by diabetic neuropathy and explore the common symptoms and complications associated with diabetic neuropathy in the pain medicine field.
Recent Findings
This review highlights advances in understanding the pathophysiology of diabetic neuropathy as well as reviews potential novel therapeutic strategies and promising areas for future research.
Summary
In conclusion, this review article aims to shed light on the pathophysiology of diabetic neuropathy, its far-reaching consequences, and the evolving strategies for prevention and management. In understanding the mechanisms of diabetic neuropathy and the ongoing research in this area, healthcare professionals can better serve patients with diabetes, ultimately improving well-being and reducing complications.</description><identifier>ISSN: 1531-3433</identifier><identifier>EISSN: 1534-3081</identifier><identifier>DOI: 10.1007/s11916-024-01243-5</identifier><identifier>PMID: 38558164</identifier><language>eng</language><publisher>New York: Springer US</publisher><subject>Diabetes ; Diabetic Neuropathies - physiopathology ; Diabetic neuropathy ; Humans ; Hyperglycemia ; Hyperglycemia - complications ; Hyperglycemia - physiopathology ; Internal Medicine ; Medicine ; Medicine & Public Health ; Neuropathic Pain (A Abd-Elsayed ; Pain Medicine ; Pathophysiology ; Risk Factors ; Section Editor ; Topical Collection on Neuropathic Pain</subject><ispartof>Current pain and headache reports, 2024-06, Vol.28 (6), p.481-487</ispartof><rights>The Author(s), under exclusive licence to Springer Science+Business Media, LLC, part of Springer Nature 2024. Springer Nature or its licensor (e.g. a society or other partner) holds exclusive rights to this article under a publishing agreement with the author(s) or other rightsholder(s); author self-archiving of the accepted manuscript version of this article is solely governed by the terms of such publishing agreement and applicable law.</rights><rights>2024. The Author(s), under exclusive licence to Springer Science+Business Media, LLC, part of Springer Nature.</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c375t-12b185a10ef006ed5c87316df4825d215b07dfe48a6c4d5be877fd110ae102a23</citedby><cites>FETCH-LOGICAL-c375t-12b185a10ef006ed5c87316df4825d215b07dfe48a6c4d5be877fd110ae102a23</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://link.springer.com/content/pdf/10.1007/s11916-024-01243-5$$EPDF$$P50$$Gspringer$$H</linktopdf><linktohtml>$$Uhttps://link.springer.com/10.1007/s11916-024-01243-5$$EHTML$$P50$$Gspringer$$H</linktohtml><link.rule.ids>315,782,786,27931,27932,41495,42564,51326</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/38558164$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Strand, Natalie</creatorcontrib><creatorcontrib>Anderson, Meredith A.</creatorcontrib><creatorcontrib>Attanti, Sumedha</creatorcontrib><creatorcontrib>Gill, Benjamin</creatorcontrib><creatorcontrib>Wie, Christopher</creatorcontrib><creatorcontrib>Dawodu, Azizat</creatorcontrib><creatorcontrib>Pagan-Rosado, Robert</creatorcontrib><creatorcontrib>Harbell, Monica W.</creatorcontrib><creatorcontrib>Maloney, Jillian A.</creatorcontrib><title>Diabetic Neuropathy: Pathophysiology Review</title><title>Current pain and headache reports</title><addtitle>Curr Pain Headache Rep</addtitle><addtitle>Curr Pain Headache Rep</addtitle><description>Purpose of Review
Diabetic neuropathy is a debilitating complication of diabetes mellitus that affects millions of individuals worldwide. It is characterized by nerve damage resulting from prolonged exposure to high blood glucose levels. Diabetic neuropathy may cause a range of symptoms, including pain, numbness, muscle weakness, autonomic dysfunction, and foot ulcers, potentially causing significant impairment to the quality of life for those affected. This review article aims to provide a comprehensive overview of the pathophysiology of diabetic neuropathy. The etiology of diabetic neuropathy will be discussed, including risk factors, predisposing conditions, and an overview of the complex interplay between hyperglycemia, metabolic dysregulation, and nerve damage. Additionally, we will explore the molecular mechanisms and pathways of diabetic neuropathy, including the impact of hyperglycemia on nerve function, abnormalities in glucose metabolism, the role of advanced glycation end products (AGEs), and inflammatory and immune-mediated processes. We will provide an overview of the various nerve fibers affected by diabetic neuropathy and explore the common symptoms and complications associated with diabetic neuropathy in the pain medicine field.
Recent Findings
This review highlights advances in understanding the pathophysiology of diabetic neuropathy as well as reviews potential novel therapeutic strategies and promising areas for future research.
Summary
In conclusion, this review article aims to shed light on the pathophysiology of diabetic neuropathy, its far-reaching consequences, and the evolving strategies for prevention and management. In understanding the mechanisms of diabetic neuropathy and the ongoing research in this area, healthcare professionals can better serve patients with diabetes, ultimately improving well-being and reducing complications.</description><subject>Diabetes</subject><subject>Diabetic Neuropathies - physiopathology</subject><subject>Diabetic neuropathy</subject><subject>Humans</subject><subject>Hyperglycemia</subject><subject>Hyperglycemia - complications</subject><subject>Hyperglycemia - physiopathology</subject><subject>Internal Medicine</subject><subject>Medicine</subject><subject>Medicine & Public Health</subject><subject>Neuropathic Pain (A Abd-Elsayed</subject><subject>Pain Medicine</subject><subject>Pathophysiology</subject><subject>Risk Factors</subject><subject>Section Editor</subject><subject>Topical Collection on Neuropathic Pain</subject><issn>1531-3433</issn><issn>1534-3081</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2024</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNp9kE1Lw0AQhhdRrFb_gAcpeBFkdWY_ktWb1E8oKqLnZZNs2pS0ibuJkn_v2lQFD55mYJ55Z3gIOUA4RYD4zCOeY0SBCQrIBKdyg-yg5IJyULi56pFywfmA7Ho_B2CgFG6TAVdSKozEDjm5KkximyIdPdjWVbVpZt3F6CmUqp51vqjKatqNnu17YT_2yFZuSm_313VIXm-uX8Z3dPJ4ez--nNCUx7KhyBJU0iDYHCCymUxVzDHKcqGYzBjKBOIst0KZKBWZTKyK4zxDBGMRmGF8SI773NpVb631jV4UPrVlaZa2ar3mwBE5U8gDevQHnVetW4bvAhVJRMFEFCjWU6mrvHc217UrFsZ1GkF_qdS9Sh1U6pVKLcPS4Tq6TRY2-1n5dhcA3gM-jJZT635v_xP7CTXzfGQ</recordid><startdate>20240601</startdate><enddate>20240601</enddate><creator>Strand, Natalie</creator><creator>Anderson, Meredith A.</creator><creator>Attanti, Sumedha</creator><creator>Gill, Benjamin</creator><creator>Wie, Christopher</creator><creator>Dawodu, Azizat</creator><creator>Pagan-Rosado, Robert</creator><creator>Harbell, Monica W.</creator><creator>Maloney, Jillian A.</creator><general>Springer US</general><general>Springer Nature B.V</general><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>K9.</scope><scope>7X8</scope></search><sort><creationdate>20240601</creationdate><title>Diabetic Neuropathy: Pathophysiology Review</title><author>Strand, Natalie ; Anderson, Meredith A. ; Attanti, Sumedha ; Gill, Benjamin ; Wie, Christopher ; Dawodu, Azizat ; Pagan-Rosado, Robert ; Harbell, Monica W. ; Maloney, Jillian A.</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c375t-12b185a10ef006ed5c87316df4825d215b07dfe48a6c4d5be877fd110ae102a23</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2024</creationdate><topic>Diabetes</topic><topic>Diabetic Neuropathies - physiopathology</topic><topic>Diabetic neuropathy</topic><topic>Humans</topic><topic>Hyperglycemia</topic><topic>Hyperglycemia - complications</topic><topic>Hyperglycemia - physiopathology</topic><topic>Internal Medicine</topic><topic>Medicine</topic><topic>Medicine & Public Health</topic><topic>Neuropathic Pain (A Abd-Elsayed</topic><topic>Pain Medicine</topic><topic>Pathophysiology</topic><topic>Risk Factors</topic><topic>Section Editor</topic><topic>Topical Collection on Neuropathic Pain</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Strand, Natalie</creatorcontrib><creatorcontrib>Anderson, Meredith A.</creatorcontrib><creatorcontrib>Attanti, Sumedha</creatorcontrib><creatorcontrib>Gill, Benjamin</creatorcontrib><creatorcontrib>Wie, Christopher</creatorcontrib><creatorcontrib>Dawodu, Azizat</creatorcontrib><creatorcontrib>Pagan-Rosado, Robert</creatorcontrib><creatorcontrib>Harbell, Monica W.</creatorcontrib><creatorcontrib>Maloney, Jillian A.</creatorcontrib><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>ProQuest Health & Medical Complete (Alumni)</collection><collection>MEDLINE - Academic</collection><jtitle>Current pain and headache reports</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Strand, Natalie</au><au>Anderson, Meredith A.</au><au>Attanti, Sumedha</au><au>Gill, Benjamin</au><au>Wie, Christopher</au><au>Dawodu, Azizat</au><au>Pagan-Rosado, Robert</au><au>Harbell, Monica W.</au><au>Maloney, Jillian A.</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Diabetic Neuropathy: Pathophysiology Review</atitle><jtitle>Current pain and headache reports</jtitle><stitle>Curr Pain Headache Rep</stitle><addtitle>Curr Pain Headache Rep</addtitle><date>2024-06-01</date><risdate>2024</risdate><volume>28</volume><issue>6</issue><spage>481</spage><epage>487</epage><pages>481-487</pages><issn>1531-3433</issn><eissn>1534-3081</eissn><abstract>Purpose of Review
Diabetic neuropathy is a debilitating complication of diabetes mellitus that affects millions of individuals worldwide. It is characterized by nerve damage resulting from prolonged exposure to high blood glucose levels. Diabetic neuropathy may cause a range of symptoms, including pain, numbness, muscle weakness, autonomic dysfunction, and foot ulcers, potentially causing significant impairment to the quality of life for those affected. This review article aims to provide a comprehensive overview of the pathophysiology of diabetic neuropathy. The etiology of diabetic neuropathy will be discussed, including risk factors, predisposing conditions, and an overview of the complex interplay between hyperglycemia, metabolic dysregulation, and nerve damage. Additionally, we will explore the molecular mechanisms and pathways of diabetic neuropathy, including the impact of hyperglycemia on nerve function, abnormalities in glucose metabolism, the role of advanced glycation end products (AGEs), and inflammatory and immune-mediated processes. We will provide an overview of the various nerve fibers affected by diabetic neuropathy and explore the common symptoms and complications associated with diabetic neuropathy in the pain medicine field.
Recent Findings
This review highlights advances in understanding the pathophysiology of diabetic neuropathy as well as reviews potential novel therapeutic strategies and promising areas for future research.
Summary
In conclusion, this review article aims to shed light on the pathophysiology of diabetic neuropathy, its far-reaching consequences, and the evolving strategies for prevention and management. In understanding the mechanisms of diabetic neuropathy and the ongoing research in this area, healthcare professionals can better serve patients with diabetes, ultimately improving well-being and reducing complications.</abstract><cop>New York</cop><pub>Springer US</pub><pmid>38558164</pmid><doi>10.1007/s11916-024-01243-5</doi><tpages>7</tpages></addata></record> |
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subjects | Diabetes Diabetic Neuropathies - physiopathology Diabetic neuropathy Humans Hyperglycemia Hyperglycemia - complications Hyperglycemia - physiopathology Internal Medicine Medicine Medicine & Public Health Neuropathic Pain (A Abd-Elsayed Pain Medicine Pathophysiology Risk Factors Section Editor Topical Collection on Neuropathic Pain |
title | Diabetic Neuropathy: Pathophysiology Review |
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