Adaptive NK Cells Rapidly Expand during Acute HIV Infection and Persist Despite Early Initiation of Antiretroviral Therapy

HIV is associated with NK cell dysfunction and expansion of adaptive-like NK cells that persist despite antiretroviral therapy (ART). We investigated the timing of NK cell perturbations during acute HIV infection and the impact of early ART initiation. PBMCs and plasma were obtained from people with...

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Veröffentlicht in:	The Journal of immunology (1950) 2024-05, Vol.212 (10), p.1553-1563
Hauptverfasser:	Hearps, Anna C, Zhou, Jingling, Agius, Paul A, Ha, Phuongnhi, Lee, Silvia, Price, Patricia, Kek, Hans, Kroon, Eugene, Akapirat, Siriwat, Pinyakorn, Suteeraporn, Phanuphak, Nittaya, Sacdalan, Carlo, Hsu, Denise, Ananworanich, Jintanat, Vasan, Sandhya, Schuetz, Alexandra, Jaworowski, Anthony
Format:	Artikel
Sprache:	eng
Schlagworte:	Acute Disease Adaptive Immunity Adult Anti-Retroviral Agents - therapeutic use HIV Infections - drug therapy HIV Infections - immunology HIV-1 - immunology Humans Killer Cells, Natural - immunology Male Young Adult
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