Risk of depression and anxiety in multiple sclerosis and neuromyelitis optica spectrum disorder: A nationwide cohort study in South Korea
Background: We investigated the risks of depression/anxiety in patients with multiple sclerosis (pwMS) or patients with neuromyelitis optica spectrum disorder (pwNMOSD). Objectives: MS/NMOSD cohorts were collected from Korean National Health Insurance Service, using the International Classification...
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| Veröffentlicht in: | Multiple sclerosis 2024-05, Vol.30 (6), p.714-725 |
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| container_issue | 6 |
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| container_title | Multiple sclerosis |
| container_volume | 30 |
| creator | Kwon, Soonwook Han, Kyung-Do Jung, Jin Hyung Cho, Eun Bin Chung, Yeon Hak Park, Junhee Choi, Hea Lim Jeon, Hong Jin Shin, Dong Wook Min, Ju-Hong |
| description | Background:
We investigated the risks of depression/anxiety in patients with multiple sclerosis (pwMS) or patients with neuromyelitis optica spectrum disorder (pwNMOSD).
Objectives:
MS/NMOSD cohorts were collected from Korean National Health Insurance Service, using the International Classification of Diseases-10th and information on Rare Intractable Disease program. Patients who were younger than 20 years, had a previous depression/anxiety, or died in the index year were excluded.
Methods:
Hazard ratios (HRs) of depression/anxiety in pwMS and pwNMOSD from controls matched 1:5 for age, sex, hypertension, diabetes, and dyslipidemia were calculated using Cox regressions with a 1-year lag period and estimated over time.
Results:
During a mean follow-up of 4.1 years, adjusted hazard ratios (aHR) for depression were 3.25 (95% confidence interval (CI) = 2.59–4.07) in MS and 2.17 (1.70–2.76) in NMOSD, and aHRs for anxiety were 1.83 (1.49–2.23) in MS and 1.56 (1.26–1.91) in NMOSD. The risks of anxiety/depression did not differ between MS and NMOSD and were highest in the second year after diagnosis of MS/NMOSD. The relative risk of depression was higher in younger pwMS/pwNMOSD, and the relative risk of anxiety was higher in pwMS who was male, had low income, or lived in a non-urban area.
Conclusion:
The risk of depression and anxiety was increased in pwMS/pwNMOSD. |
| doi_str_mv | 10.1177/13524585241237093 |
| format | Article |
| fullrecord | <record><control><sourceid>proquest_cross</sourceid><recordid>TN_cdi_proquest_miscellaneous_3031131090</recordid><sourceformat>XML</sourceformat><sourcesystem>PC</sourcesystem><sage_id>10.1177_13524585241237093</sage_id><sourcerecordid>3051332694</sourcerecordid><originalsourceid>FETCH-LOGICAL-c320t-781f4634f6b487e89eb5915d9b37be69849e29c5e4610e84d59cec376e59e1c3</originalsourceid><addsrcrecordid>eNp1kV9v1iAUh4nRuD_6AbwxJN7sphMKlLK7ZXGbcYmJ7r5p4XRjtqXjQOb7EfzWY3s3TTReACfwnAfCj5B3nB1yrvVHLlQtVVsmXgvNjHhBdrnUumJGs5elLufVA7BD9hBvGGNaC_Wa7IhWNdwosUt-ffP4g4aROlgjIPqw0H5xZfz0kDbUL3TOU_LrBBTtBDGgx0digRzDvIHJp7IT1uRtT3EFm2KeqfMYooN4RI_p0qeivfMOqA3XISaKKbtH9_eQ0zX9EiL0b8irsZ8Q3j6t--Ty9NPlyXl18fXs88nxRWVFzVKlWz7KRsixGWSroTUwKMOVM4PQAzSmlQZqYxXIhjNopVPGghW6AWWAW7FPDrbaNYbbDJi62aOFaeoXCBk7wQTngjPDCvrhL_Qm5LiUxxVKcSHqxshC8S1ly99ghLFbo5_7uOk46x5i6v6JqfS8fzLnYQb3u-M5lwIcbgHsr-DPtf833gPTMJuu</addsrcrecordid><sourcetype>Aggregation Database</sourcetype><iscdi>true</iscdi><recordtype>article</recordtype><pqid>3051332694</pqid></control><display><type>article</type><title>Risk of depression and anxiety in multiple sclerosis and neuromyelitis optica spectrum disorder: A nationwide cohort study in South Korea</title><source>Access via SAGE</source><creator>Kwon, Soonwook ; Han, Kyung-Do ; Jung, Jin Hyung ; Cho, Eun Bin ; Chung, Yeon Hak ; Park, Junhee ; Choi, Hea Lim ; Jeon, Hong Jin ; Shin, Dong Wook ; Min, Ju-Hong</creator><creatorcontrib>Kwon, Soonwook ; Han, Kyung-Do ; Jung, Jin Hyung ; Cho, Eun Bin ; Chung, Yeon Hak ; Park, Junhee ; Choi, Hea Lim ; Jeon, Hong Jin ; Shin, Dong Wook ; Min, Ju-Hong</creatorcontrib><description>Background:
We investigated the risks of depression/anxiety in patients with multiple sclerosis (pwMS) or patients with neuromyelitis optica spectrum disorder (pwNMOSD).
Objectives:
MS/NMOSD cohorts were collected from Korean National Health Insurance Service, using the International Classification of Diseases-10th and information on Rare Intractable Disease program. Patients who were younger than 20 years, had a previous depression/anxiety, or died in the index year were excluded.
Methods:
Hazard ratios (HRs) of depression/anxiety in pwMS and pwNMOSD from controls matched 1:5 for age, sex, hypertension, diabetes, and dyslipidemia were calculated using Cox regressions with a 1-year lag period and estimated over time.
Results:
During a mean follow-up of 4.1 years, adjusted hazard ratios (aHR) for depression were 3.25 (95% confidence interval (CI) = 2.59–4.07) in MS and 2.17 (1.70–2.76) in NMOSD, and aHRs for anxiety were 1.83 (1.49–2.23) in MS and 1.56 (1.26–1.91) in NMOSD. The risks of anxiety/depression did not differ between MS and NMOSD and were highest in the second year after diagnosis of MS/NMOSD. The relative risk of depression was higher in younger pwMS/pwNMOSD, and the relative risk of anxiety was higher in pwMS who was male, had low income, or lived in a non-urban area.
Conclusion:
The risk of depression and anxiety was increased in pwMS/pwNMOSD.</description><identifier>ISSN: 1352-4585</identifier><identifier>EISSN: 1477-0970</identifier><identifier>DOI: 10.1177/13524585241237093</identifier><identifier>PMID: 38561953</identifier><language>eng</language><publisher>London, England: SAGE Publications</publisher><subject>Anxiety ; Diabetes mellitus ; Dyslipidemia ; Mental depression ; Multiple sclerosis ; Neuromyelitis</subject><ispartof>Multiple sclerosis, 2024-05, Vol.30 (6), p.714-725</ispartof><rights>The Author(s), 2024</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><cites>FETCH-LOGICAL-c320t-781f4634f6b487e89eb5915d9b37be69849e29c5e4610e84d59cec376e59e1c3</cites><orcidid>0000-0002-7338-9067 ; 0000-0002-5578-7571 ; 0000-0002-7052-2432</orcidid></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://journals.sagepub.com/doi/pdf/10.1177/13524585241237093$$EPDF$$P50$$Gsage$$H</linktopdf><linktohtml>$$Uhttps://journals.sagepub.com/doi/10.1177/13524585241237093$$EHTML$$P50$$Gsage$$H</linktohtml><link.rule.ids>314,780,784,21819,27924,27925,43621,43622</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/38561953$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Kwon, Soonwook</creatorcontrib><creatorcontrib>Han, Kyung-Do</creatorcontrib><creatorcontrib>Jung, Jin Hyung</creatorcontrib><creatorcontrib>Cho, Eun Bin</creatorcontrib><creatorcontrib>Chung, Yeon Hak</creatorcontrib><creatorcontrib>Park, Junhee</creatorcontrib><creatorcontrib>Choi, Hea Lim</creatorcontrib><creatorcontrib>Jeon, Hong Jin</creatorcontrib><creatorcontrib>Shin, Dong Wook</creatorcontrib><creatorcontrib>Min, Ju-Hong</creatorcontrib><title>Risk of depression and anxiety in multiple sclerosis and neuromyelitis optica spectrum disorder: A nationwide cohort study in South Korea</title><title>Multiple sclerosis</title><addtitle>Mult Scler</addtitle><description>Background:
We investigated the risks of depression/anxiety in patients with multiple sclerosis (pwMS) or patients with neuromyelitis optica spectrum disorder (pwNMOSD).
Objectives:
MS/NMOSD cohorts were collected from Korean National Health Insurance Service, using the International Classification of Diseases-10th and information on Rare Intractable Disease program. Patients who were younger than 20 years, had a previous depression/anxiety, or died in the index year were excluded.
Methods:
Hazard ratios (HRs) of depression/anxiety in pwMS and pwNMOSD from controls matched 1:5 for age, sex, hypertension, diabetes, and dyslipidemia were calculated using Cox regressions with a 1-year lag period and estimated over time.
Results:
During a mean follow-up of 4.1 years, adjusted hazard ratios (aHR) for depression were 3.25 (95% confidence interval (CI) = 2.59–4.07) in MS and 2.17 (1.70–2.76) in NMOSD, and aHRs for anxiety were 1.83 (1.49–2.23) in MS and 1.56 (1.26–1.91) in NMOSD. The risks of anxiety/depression did not differ between MS and NMOSD and were highest in the second year after diagnosis of MS/NMOSD. The relative risk of depression was higher in younger pwMS/pwNMOSD, and the relative risk of anxiety was higher in pwMS who was male, had low income, or lived in a non-urban area.
Conclusion:
The risk of depression and anxiety was increased in pwMS/pwNMOSD.</description><subject>Anxiety</subject><subject>Diabetes mellitus</subject><subject>Dyslipidemia</subject><subject>Mental depression</subject><subject>Multiple sclerosis</subject><subject>Neuromyelitis</subject><issn>1352-4585</issn><issn>1477-0970</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2024</creationdate><recordtype>article</recordtype><recordid>eNp1kV9v1iAUh4nRuD_6AbwxJN7sphMKlLK7ZXGbcYmJ7r5p4XRjtqXjQOb7EfzWY3s3TTReACfwnAfCj5B3nB1yrvVHLlQtVVsmXgvNjHhBdrnUumJGs5elLufVA7BD9hBvGGNaC_Wa7IhWNdwosUt-ffP4g4aROlgjIPqw0H5xZfz0kDbUL3TOU_LrBBTtBDGgx0digRzDvIHJp7IT1uRtT3EFm2KeqfMYooN4RI_p0qeivfMOqA3XISaKKbtH9_eQ0zX9EiL0b8irsZ8Q3j6t--Ty9NPlyXl18fXs88nxRWVFzVKlWz7KRsixGWSroTUwKMOVM4PQAzSmlQZqYxXIhjNopVPGghW6AWWAW7FPDrbaNYbbDJi62aOFaeoXCBk7wQTngjPDCvrhL_Qm5LiUxxVKcSHqxshC8S1ly99ghLFbo5_7uOk46x5i6v6JqfS8fzLnYQb3u-M5lwIcbgHsr-DPtf833gPTMJuu</recordid><startdate>20240501</startdate><enddate>20240501</enddate><creator>Kwon, Soonwook</creator><creator>Han, Kyung-Do</creator><creator>Jung, Jin Hyung</creator><creator>Cho, Eun Bin</creator><creator>Chung, Yeon Hak</creator><creator>Park, Junhee</creator><creator>Choi, Hea Lim</creator><creator>Jeon, Hong Jin</creator><creator>Shin, Dong Wook</creator><creator>Min, Ju-Hong</creator><general>SAGE Publications</general><general>Sage Publications Ltd</general><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7T5</scope><scope>7TK</scope><scope>7U9</scope><scope>H94</scope><scope>K9.</scope><scope>7X8</scope><orcidid>https://orcid.org/0000-0002-7338-9067</orcidid><orcidid>https://orcid.org/0000-0002-5578-7571</orcidid><orcidid>https://orcid.org/0000-0002-7052-2432</orcidid></search><sort><creationdate>20240501</creationdate><title>Risk of depression and anxiety in multiple sclerosis and neuromyelitis optica spectrum disorder: A nationwide cohort study in South Korea</title><author>Kwon, Soonwook ; Han, Kyung-Do ; Jung, Jin Hyung ; Cho, Eun Bin ; Chung, Yeon Hak ; Park, Junhee ; Choi, Hea Lim ; Jeon, Hong Jin ; Shin, Dong Wook ; Min, Ju-Hong</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c320t-781f4634f6b487e89eb5915d9b37be69849e29c5e4610e84d59cec376e59e1c3</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2024</creationdate><topic>Anxiety</topic><topic>Diabetes mellitus</topic><topic>Dyslipidemia</topic><topic>Mental depression</topic><topic>Multiple sclerosis</topic><topic>Neuromyelitis</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Kwon, Soonwook</creatorcontrib><creatorcontrib>Han, Kyung-Do</creatorcontrib><creatorcontrib>Jung, Jin Hyung</creatorcontrib><creatorcontrib>Cho, Eun Bin</creatorcontrib><creatorcontrib>Chung, Yeon Hak</creatorcontrib><creatorcontrib>Park, Junhee</creatorcontrib><creatorcontrib>Choi, Hea Lim</creatorcontrib><creatorcontrib>Jeon, Hong Jin</creatorcontrib><creatorcontrib>Shin, Dong Wook</creatorcontrib><creatorcontrib>Min, Ju-Hong</creatorcontrib><collection>PubMed</collection><collection>CrossRef</collection><collection>Immunology Abstracts</collection><collection>Neurosciences Abstracts</collection><collection>Virology and AIDS Abstracts</collection><collection>AIDS and Cancer Research Abstracts</collection><collection>ProQuest Health & Medical Complete (Alumni)</collection><collection>MEDLINE - Academic</collection><jtitle>Multiple sclerosis</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Kwon, Soonwook</au><au>Han, Kyung-Do</au><au>Jung, Jin Hyung</au><au>Cho, Eun Bin</au><au>Chung, Yeon Hak</au><au>Park, Junhee</au><au>Choi, Hea Lim</au><au>Jeon, Hong Jin</au><au>Shin, Dong Wook</au><au>Min, Ju-Hong</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Risk of depression and anxiety in multiple sclerosis and neuromyelitis optica spectrum disorder: A nationwide cohort study in South Korea</atitle><jtitle>Multiple sclerosis</jtitle><addtitle>Mult Scler</addtitle><date>2024-05-01</date><risdate>2024</risdate><volume>30</volume><issue>6</issue><spage>714</spage><epage>725</epage><pages>714-725</pages><issn>1352-4585</issn><eissn>1477-0970</eissn><abstract>Background:
We investigated the risks of depression/anxiety in patients with multiple sclerosis (pwMS) or patients with neuromyelitis optica spectrum disorder (pwNMOSD).
Objectives:
MS/NMOSD cohorts were collected from Korean National Health Insurance Service, using the International Classification of Diseases-10th and information on Rare Intractable Disease program. Patients who were younger than 20 years, had a previous depression/anxiety, or died in the index year were excluded.
Methods:
Hazard ratios (HRs) of depression/anxiety in pwMS and pwNMOSD from controls matched 1:5 for age, sex, hypertension, diabetes, and dyslipidemia were calculated using Cox regressions with a 1-year lag period and estimated over time.
Results:
During a mean follow-up of 4.1 years, adjusted hazard ratios (aHR) for depression were 3.25 (95% confidence interval (CI) = 2.59–4.07) in MS and 2.17 (1.70–2.76) in NMOSD, and aHRs for anxiety were 1.83 (1.49–2.23) in MS and 1.56 (1.26–1.91) in NMOSD. The risks of anxiety/depression did not differ between MS and NMOSD and were highest in the second year after diagnosis of MS/NMOSD. The relative risk of depression was higher in younger pwMS/pwNMOSD, and the relative risk of anxiety was higher in pwMS who was male, had low income, or lived in a non-urban area.
Conclusion:
The risk of depression and anxiety was increased in pwMS/pwNMOSD.</abstract><cop>London, England</cop><pub>SAGE Publications</pub><pmid>38561953</pmid><doi>10.1177/13524585241237093</doi><tpages>12</tpages><orcidid>https://orcid.org/0000-0002-7338-9067</orcidid><orcidid>https://orcid.org/0000-0002-5578-7571</orcidid><orcidid>https://orcid.org/0000-0002-7052-2432</orcidid></addata></record> |
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| ispartof | Multiple sclerosis, 2024-05, Vol.30 (6), p.714-725 |
| issn | 1352-4585 1477-0970 |
| language | eng |
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| source | Access via SAGE |
| subjects | Anxiety Diabetes mellitus Dyslipidemia Mental depression Multiple sclerosis Neuromyelitis |
| title | Risk of depression and anxiety in multiple sclerosis and neuromyelitis optica spectrum disorder: A nationwide cohort study in South Korea |
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