Serum netrin-1 levels are high in Rheumatoid arthritis associated interstitial lung disease
Recent data show that netrin-1 has a role in development of pulmonary fibrosis. This study was aimed to investigate serum netrin-1 level and its relation to interstitial lung disease(ILD) in patients with rheumatoid arthritis (RA). 42 RA patients with RA-ILD, 58 RA patients without RA-ILD (RA non-IL...
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| Veröffentlicht in: | Clinical biochemistry 2024-05, Vol.127-128, p.110760-110760, Article 110760 |
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| container_title | Clinical biochemistry |
| container_volume | 127-128 |
| creator | Kor, Ahmet Güven, Serdar Can Akan, Selçuk Eren, Funda Ecem Konak, Hatice Maraş, Yüksel Orhan, Kevser Neşelioğlu, Salim Erten, Şükran |
| description | Recent data show that netrin-1 has a role in development of pulmonary fibrosis. This study was aimed to investigate serum netrin-1 level and its relation to interstitial lung disease(ILD) in patients with rheumatoid arthritis (RA).
42 RA patients with RA-ILD, 58 RA patients without RA-ILD (RA non-ILD group), and 61 healthy volunteers were included in this study. The modified DAS28-ESR score was used to calculate disease activity in RA patients. Using the quantitative immunoassay method, Serum netrin-1 levels were measured with an ELISA kit (Catalog number: E-EL-H2328; lab science, lot number: GZWTKZ5SWK, Texas, USA).
The median value of netrin-1 was found to be significantly higher in the RA-ILD group (82.9 [59.9–124]) compared to both the RA non-ILD group(52.9 [49.5–73.1])(B = −0.006, OR = 0.994, CI 95 %=0.989–0.999, P = 0.018) and the control group(53.5 [49.5–87.5]) (B: −0.005, OR: 0.994, CI 95 %: 0.990–0.999, p: 0.022). A cut-off value of 61.78 for netrin-1 was found to have a sensitivity of 73.8 % and a specificity of 69 % for the diagnosis of RA-ILD (AUC [95 %Cl] = 0.771 [0.679–0.862], p |
| doi_str_mv | 10.1016/j.clinbiochem.2024.110760 |
| format | Article |
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42 RA patients with RA-ILD, 58 RA patients without RA-ILD (RA non-ILD group), and 61 healthy volunteers were included in this study. The modified DAS28-ESR score was used to calculate disease activity in RA patients. Using the quantitative immunoassay method, Serum netrin-1 levels were measured with an ELISA kit (Catalog number: E-EL-H2328; lab science, lot number: GZWTKZ5SWK, Texas, USA).
The median value of netrin-1 was found to be significantly higher in the RA-ILD group (82.9 [59.9–124]) compared to both the RA non-ILD group(52.9 [49.5–73.1])(B = −0.006, OR = 0.994, CI 95 %=0.989–0.999, P = 0.018) and the control group(53.5 [49.5–87.5]) (B: −0.005, OR: 0.994, CI 95 %: 0.990–0.999, p: 0.022). A cut-off value of 61.78 for netrin-1 was found to have a sensitivity of 73.8 % and a specificity of 69 % for the diagnosis of RA-ILD (AUC [95 %Cl] = 0.771 [0.679–0.862], p < 0.0001).It was found that high serum netrin-1 level was strongly associated with the RA-usual interstitial pneumonia(UIP) pattern and poorly related to the RA-nonspecific interstitial pneumonia(NSIP) pattern compared to the RA non-ILD group.
Netrin-1 is elevated in the serum of patients with RA-ILD, especially in the UIP pattern. Netrin-1 may be a potential candidate for predicting the development of RA-ILD that should be investigated in the pathophysiological and therapeutic fields..</description><identifier>ISSN: 0009-9120</identifier><identifier>EISSN: 1873-2933</identifier><identifier>DOI: 10.1016/j.clinbiochem.2024.110760</identifier><identifier>PMID: 38556035</identifier><language>eng</language><publisher>United States: Elsevier Inc</publisher><subject>Adult ; Aged ; Arthritis, Rheumatoid - blood ; Arthritis, Rheumatoid - complications ; Biomarkers - blood ; Case-Control Studies ; Female ; Humans ; Interstitial lung disease ; Lung Diseases, Interstitial - blood ; Lung Diseases, Interstitial - complications ; Lung Diseases, Interstitial - etiology ; Male ; Middle Aged ; Netrin-1 ; Netrin-1 - blood ; Pulmonary fibrosis ; Rheumatoid arthritis</subject><ispartof>Clinical biochemistry, 2024-05, Vol.127-128, p.110760-110760, Article 110760</ispartof><rights>2024 The Canadian Society of Clinical Chemists</rights><rights>Copyright © 2024 The Canadian Society of Clinical Chemists. Published by Elsevier Inc. All rights reserved.</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><cites>FETCH-LOGICAL-c321t-c996412db363c58ce054eb24bab11a3c71a4739db7187f947e9499f37d4df0853</cites><orcidid>0000-0002-5794-6951 ; 0000-0001-9319-0955</orcidid></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktohtml>$$Uhttps://www.sciencedirect.com/science/article/pii/S0009912024000547$$EHTML$$P50$$Gelsevier$$H</linktohtml><link.rule.ids>314,776,780,3536,27903,27904,65309</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/38556035$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Kor, Ahmet</creatorcontrib><creatorcontrib>Güven, Serdar Can</creatorcontrib><creatorcontrib>Akan, Selçuk</creatorcontrib><creatorcontrib>Eren, Funda</creatorcontrib><creatorcontrib>Ecem Konak, Hatice</creatorcontrib><creatorcontrib>Maraş, Yüksel</creatorcontrib><creatorcontrib>Orhan, Kevser</creatorcontrib><creatorcontrib>Neşelioğlu, Salim</creatorcontrib><creatorcontrib>Erten, Şükran</creatorcontrib><title>Serum netrin-1 levels are high in Rheumatoid arthritis associated interstitial lung disease</title><title>Clinical biochemistry</title><addtitle>Clin Biochem</addtitle><description>Recent data show that netrin-1 has a role in development of pulmonary fibrosis. This study was aimed to investigate serum netrin-1 level and its relation to interstitial lung disease(ILD) in patients with rheumatoid arthritis (RA).
42 RA patients with RA-ILD, 58 RA patients without RA-ILD (RA non-ILD group), and 61 healthy volunteers were included in this study. The modified DAS28-ESR score was used to calculate disease activity in RA patients. Using the quantitative immunoassay method, Serum netrin-1 levels were measured with an ELISA kit (Catalog number: E-EL-H2328; lab science, lot number: GZWTKZ5SWK, Texas, USA).
The median value of netrin-1 was found to be significantly higher in the RA-ILD group (82.9 [59.9–124]) compared to both the RA non-ILD group(52.9 [49.5–73.1])(B = −0.006, OR = 0.994, CI 95 %=0.989–0.999, P = 0.018) and the control group(53.5 [49.5–87.5]) (B: −0.005, OR: 0.994, CI 95 %: 0.990–0.999, p: 0.022). A cut-off value of 61.78 for netrin-1 was found to have a sensitivity of 73.8 % and a specificity of 69 % for the diagnosis of RA-ILD (AUC [95 %Cl] = 0.771 [0.679–0.862], p < 0.0001).It was found that high serum netrin-1 level was strongly associated with the RA-usual interstitial pneumonia(UIP) pattern and poorly related to the RA-nonspecific interstitial pneumonia(NSIP) pattern compared to the RA non-ILD group.
Netrin-1 is elevated in the serum of patients with RA-ILD, especially in the UIP pattern. Netrin-1 may be a potential candidate for predicting the development of RA-ILD that should be investigated in the pathophysiological and therapeutic fields..</description><subject>Adult</subject><subject>Aged</subject><subject>Arthritis, Rheumatoid - blood</subject><subject>Arthritis, Rheumatoid - complications</subject><subject>Biomarkers - blood</subject><subject>Case-Control Studies</subject><subject>Female</subject><subject>Humans</subject><subject>Interstitial lung disease</subject><subject>Lung Diseases, Interstitial - blood</subject><subject>Lung Diseases, Interstitial - complications</subject><subject>Lung Diseases, Interstitial - etiology</subject><subject>Male</subject><subject>Middle Aged</subject><subject>Netrin-1</subject><subject>Netrin-1 - blood</subject><subject>Pulmonary fibrosis</subject><subject>Rheumatoid arthritis</subject><issn>0009-9120</issn><issn>1873-2933</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2024</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNqNkEtLAzEQx4Motla_gqw3L1vz2keOUnxBQfBx8hCyyWw3ZR81yRb89qa0ikdPwwy__wzzQ-iK4DnBJL9Zz3Vr-8oOuoFuTjHlc0JwkeMjNCVlwVIqGDtGU4yxSAWheILOvF_HlvIyP0UTVmZZjlk2RR-v4MYu6SE426ckaWELrU-Ug6SxqyaxffLSwNipMFgTx6FxNtgIeD9oqwKYiARwPsSxapN27FeJsR6Uh3N0UqvWw8WhztD7_d3b4jFdPj88LW6XqWaUhFQLkXNCTcVyprNSA844VJRXqiJEMV0QxQsmTFXE32rBCxBciJoVhpsalxmboev93o0bPkfwQXbWa2hb1cMweskwFSUpWEkiKvaodoP3Dmq5cbZT7ksSLHdu5Vr-cSt3buXebcxeHs6MVQfmN_kjMwKLPRANwtaCk15b6DUY60AHaQb7jzPfjXKQ9w</recordid><startdate>202405</startdate><enddate>202405</enddate><creator>Kor, Ahmet</creator><creator>Güven, Serdar Can</creator><creator>Akan, Selçuk</creator><creator>Eren, Funda</creator><creator>Ecem Konak, Hatice</creator><creator>Maraş, Yüksel</creator><creator>Orhan, Kevser</creator><creator>Neşelioğlu, Salim</creator><creator>Erten, Şükran</creator><general>Elsevier Inc</general><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7X8</scope><orcidid>https://orcid.org/0000-0002-5794-6951</orcidid><orcidid>https://orcid.org/0000-0001-9319-0955</orcidid></search><sort><creationdate>202405</creationdate><title>Serum netrin-1 levels are high in Rheumatoid arthritis associated interstitial lung disease</title><author>Kor, Ahmet ; Güven, Serdar Can ; Akan, Selçuk ; Eren, Funda ; Ecem Konak, Hatice ; Maraş, Yüksel ; Orhan, Kevser ; Neşelioğlu, Salim ; Erten, Şükran</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c321t-c996412db363c58ce054eb24bab11a3c71a4739db7187f947e9499f37d4df0853</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2024</creationdate><topic>Adult</topic><topic>Aged</topic><topic>Arthritis, Rheumatoid - blood</topic><topic>Arthritis, Rheumatoid - complications</topic><topic>Biomarkers - blood</topic><topic>Case-Control Studies</topic><topic>Female</topic><topic>Humans</topic><topic>Interstitial lung disease</topic><topic>Lung Diseases, Interstitial - blood</topic><topic>Lung Diseases, Interstitial - complications</topic><topic>Lung Diseases, Interstitial - etiology</topic><topic>Male</topic><topic>Middle Aged</topic><topic>Netrin-1</topic><topic>Netrin-1 - blood</topic><topic>Pulmonary fibrosis</topic><topic>Rheumatoid arthritis</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Kor, Ahmet</creatorcontrib><creatorcontrib>Güven, Serdar Can</creatorcontrib><creatorcontrib>Akan, Selçuk</creatorcontrib><creatorcontrib>Eren, Funda</creatorcontrib><creatorcontrib>Ecem Konak, Hatice</creatorcontrib><creatorcontrib>Maraş, Yüksel</creatorcontrib><creatorcontrib>Orhan, Kevser</creatorcontrib><creatorcontrib>Neşelioğlu, Salim</creatorcontrib><creatorcontrib>Erten, Şükran</creatorcontrib><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>MEDLINE - Academic</collection><jtitle>Clinical biochemistry</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Kor, Ahmet</au><au>Güven, Serdar Can</au><au>Akan, Selçuk</au><au>Eren, Funda</au><au>Ecem Konak, Hatice</au><au>Maraş, Yüksel</au><au>Orhan, Kevser</au><au>Neşelioğlu, Salim</au><au>Erten, Şükran</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Serum netrin-1 levels are high in Rheumatoid arthritis associated interstitial lung disease</atitle><jtitle>Clinical biochemistry</jtitle><addtitle>Clin Biochem</addtitle><date>2024-05</date><risdate>2024</risdate><volume>127-128</volume><spage>110760</spage><epage>110760</epage><pages>110760-110760</pages><artnum>110760</artnum><issn>0009-9120</issn><eissn>1873-2933</eissn><abstract>Recent data show that netrin-1 has a role in development of pulmonary fibrosis. This study was aimed to investigate serum netrin-1 level and its relation to interstitial lung disease(ILD) in patients with rheumatoid arthritis (RA).
42 RA patients with RA-ILD, 58 RA patients without RA-ILD (RA non-ILD group), and 61 healthy volunteers were included in this study. The modified DAS28-ESR score was used to calculate disease activity in RA patients. Using the quantitative immunoassay method, Serum netrin-1 levels were measured with an ELISA kit (Catalog number: E-EL-H2328; lab science, lot number: GZWTKZ5SWK, Texas, USA).
The median value of netrin-1 was found to be significantly higher in the RA-ILD group (82.9 [59.9–124]) compared to both the RA non-ILD group(52.9 [49.5–73.1])(B = −0.006, OR = 0.994, CI 95 %=0.989–0.999, P = 0.018) and the control group(53.5 [49.5–87.5]) (B: −0.005, OR: 0.994, CI 95 %: 0.990–0.999, p: 0.022). A cut-off value of 61.78 for netrin-1 was found to have a sensitivity of 73.8 % and a specificity of 69 % for the diagnosis of RA-ILD (AUC [95 %Cl] = 0.771 [0.679–0.862], p < 0.0001).It was found that high serum netrin-1 level was strongly associated with the RA-usual interstitial pneumonia(UIP) pattern and poorly related to the RA-nonspecific interstitial pneumonia(NSIP) pattern compared to the RA non-ILD group.
Netrin-1 is elevated in the serum of patients with RA-ILD, especially in the UIP pattern. Netrin-1 may be a potential candidate for predicting the development of RA-ILD that should be investigated in the pathophysiological and therapeutic fields..</abstract><cop>United States</cop><pub>Elsevier Inc</pub><pmid>38556035</pmid><doi>10.1016/j.clinbiochem.2024.110760</doi><tpages>1</tpages><orcidid>https://orcid.org/0000-0002-5794-6951</orcidid><orcidid>https://orcid.org/0000-0001-9319-0955</orcidid></addata></record> |
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| subjects | Adult Aged Arthritis, Rheumatoid - blood Arthritis, Rheumatoid - complications Biomarkers - blood Case-Control Studies Female Humans Interstitial lung disease Lung Diseases, Interstitial - blood Lung Diseases, Interstitial - complications Lung Diseases, Interstitial - etiology Male Middle Aged Netrin-1 Netrin-1 - blood Pulmonary fibrosis Rheumatoid arthritis |
| title | Serum netrin-1 levels are high in Rheumatoid arthritis associated interstitial lung disease |
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