The effects and potential mechanisms of essential metals on the associations of polycyclic aromatic hydrocarbons with blood cell-based inflammation markers
Polycyclic aromatic hydrocarbons (PAHs) are well-acknowledged pro-inflammatory chemicals, but their associations with blood cell-based inflammatory biomarkers need further investigation. Moreover, the effects and mechanisms of essential metals on PAH-related inflammation remain poorly understood. To...
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| Veröffentlicht in: | Environmental pollution (1987) 2024-05, Vol.349, p.123856-123856, Article 123856 |
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| container_title | Environmental pollution (1987) |
| container_volume | 349 |
| creator | Liao, Xiaojing Wu, Haimei Liu, Kang Bai, Yansen Wu, Degang Guo, Chaofan Liu, Xin Zhang, Zhaorui Huang, Yongshun Zhao, Na Xiao, Yongmei Deng, Qifei |
| description | Polycyclic aromatic hydrocarbons (PAHs) are well-acknowledged pro-inflammatory chemicals, but their associations with blood cell-based inflammatory biomarkers need further investigation. Moreover, the effects and mechanisms of essential metals on PAH-related inflammation remain poorly understood.
To elucidate the associations of PAHs on inflammatory biomarkers, as well as the effects and mechanisms of essential metals on these associations.
A cross-sectional study was conducted on 1388 coke oven workers. We analyzed the modification effects of key essential metal(s) on PAHs-inflammatory biomarkers associations. To explore the possible mechanisms from an inflammation perspective, we performed a bioinformatic analysis on the genes of PAHs and essential metals obtained from the Comparative Toxicogenomics Database (CTD) and performed a mediation analysis.
We observed associations of PAHs and essential metals with lymphocyte-to-monocyte ratio (LMR) (P |
| doi_str_mv | 10.1016/j.envpol.2024.123856 |
| format | Article |
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To elucidate the associations of PAHs on inflammatory biomarkers, as well as the effects and mechanisms of essential metals on these associations.
A cross-sectional study was conducted on 1388 coke oven workers. We analyzed the modification effects of key essential metal(s) on PAHs-inflammatory biomarkers associations. To explore the possible mechanisms from an inflammation perspective, we performed a bioinformatic analysis on the genes of PAHs and essential metals obtained from the Comparative Toxicogenomics Database (CTD) and performed a mediation analysis.
We observed associations of PAHs and essential metals with lymphocyte-to-monocyte ratio (LMR) (P < 0.05). PAH mixtures were inversely associated with LMR (βQGC-index = −0.18, P < 0.001), with 1-hydroxypyrene (1-OH-Pyr) being the most prominent contributor (weight = 63.37%), whereas a positive association between essential metal mixtures and LMR was observed (βQGC-index = 0.14, P < 0.001), with tin being the most significant contributor (weight = 51.61%). An inverse association of 1-OH-Pyr with LMR was weakened by increased tin exposure (P < 0.05). The CTD database showed that PAHs and tin compounds co-regulated 22 inflammation-associated genes, but they regulated most genes in opposite directions. Further identified the involvement of oxidative stress and mediation analysis showed that the mediation effect of 8-hydroxydeoxyguanosine (8-OHdG) on 1-OH-Pyr-LMR association presented heterogeneity between low and high tin tertile groups (I2 = 37.84%).
1-OH-Pyr and tin were significantly associated with LMR. Modification effects indicated that the inverse association of 1-OH-Pyr with LMR was mitigated with an increase in tin. The mediation effect of 8-OHdG on the inverse association of 1-OH-Pyr with LMR may be partially dependent on tin.
[Display omitted]
•PAH mixtures were related to decreased LMR, with pyrene contributing the most.•Essential metals had joint effects on elevated LMR, with tin being predominant.•Tin had a modifying effect on pyrene-LMR association.•Pyrene and tin regulated inflammation-related common genes in opposite directions.•8-OHdG mediated pyrene-LMR association and partially dependent on the dose of tin.</description><identifier>ISSN: 0269-7491</identifier><identifier>EISSN: 1873-6424</identifier><identifier>DOI: 10.1016/j.envpol.2024.123856</identifier><identifier>PMID: 38556152</identifier><language>eng</language><publisher>England: Elsevier Ltd</publisher><subject>Essential metals ; Inflammation ; Modification effect ; Polycyclic aromatic hydrocarbons ; Regulatory network</subject><ispartof>Environmental pollution (1987), 2024-05, Vol.349, p.123856-123856, Article 123856</ispartof><rights>2024 Elsevier Ltd</rights><rights>Copyright © 2024 Elsevier Ltd. All rights reserved.</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><cites>FETCH-LOGICAL-c311t-6f59243e05b860e77760fbe507c1971729b3328a4165b543d781d501aaaf9da23</cites><orcidid>0000-0002-2326-0468</orcidid></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktohtml>$$Uhttps://dx.doi.org/10.1016/j.envpol.2024.123856$$EHTML$$P50$$Gelsevier$$H</linktohtml><link.rule.ids>314,777,781,3537,27905,27906,45976</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/38556152$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Liao, Xiaojing</creatorcontrib><creatorcontrib>Wu, Haimei</creatorcontrib><creatorcontrib>Liu, Kang</creatorcontrib><creatorcontrib>Bai, Yansen</creatorcontrib><creatorcontrib>Wu, Degang</creatorcontrib><creatorcontrib>Guo, Chaofan</creatorcontrib><creatorcontrib>Liu, Xin</creatorcontrib><creatorcontrib>Zhang, Zhaorui</creatorcontrib><creatorcontrib>Huang, Yongshun</creatorcontrib><creatorcontrib>Zhao, Na</creatorcontrib><creatorcontrib>Xiao, Yongmei</creatorcontrib><creatorcontrib>Deng, Qifei</creatorcontrib><title>The effects and potential mechanisms of essential metals on the associations of polycyclic aromatic hydrocarbons with blood cell-based inflammation markers</title><title>Environmental pollution (1987)</title><addtitle>Environ Pollut</addtitle><description>Polycyclic aromatic hydrocarbons (PAHs) are well-acknowledged pro-inflammatory chemicals, but their associations with blood cell-based inflammatory biomarkers need further investigation. Moreover, the effects and mechanisms of essential metals on PAH-related inflammation remain poorly understood.
To elucidate the associations of PAHs on inflammatory biomarkers, as well as the effects and mechanisms of essential metals on these associations.
A cross-sectional study was conducted on 1388 coke oven workers. We analyzed the modification effects of key essential metal(s) on PAHs-inflammatory biomarkers associations. To explore the possible mechanisms from an inflammation perspective, we performed a bioinformatic analysis on the genes of PAHs and essential metals obtained from the Comparative Toxicogenomics Database (CTD) and performed a mediation analysis.
We observed associations of PAHs and essential metals with lymphocyte-to-monocyte ratio (LMR) (P < 0.05). PAH mixtures were inversely associated with LMR (βQGC-index = −0.18, P < 0.001), with 1-hydroxypyrene (1-OH-Pyr) being the most prominent contributor (weight = 63.37%), whereas a positive association between essential metal mixtures and LMR was observed (βQGC-index = 0.14, P < 0.001), with tin being the most significant contributor (weight = 51.61%). An inverse association of 1-OH-Pyr with LMR was weakened by increased tin exposure (P < 0.05). The CTD database showed that PAHs and tin compounds co-regulated 22 inflammation-associated genes, but they regulated most genes in opposite directions. Further identified the involvement of oxidative stress and mediation analysis showed that the mediation effect of 8-hydroxydeoxyguanosine (8-OHdG) on 1-OH-Pyr-LMR association presented heterogeneity between low and high tin tertile groups (I2 = 37.84%).
1-OH-Pyr and tin were significantly associated with LMR. Modification effects indicated that the inverse association of 1-OH-Pyr with LMR was mitigated with an increase in tin. The mediation effect of 8-OHdG on the inverse association of 1-OH-Pyr with LMR may be partially dependent on tin.
[Display omitted]
•PAH mixtures were related to decreased LMR, with pyrene contributing the most.•Essential metals had joint effects on elevated LMR, with tin being predominant.•Tin had a modifying effect on pyrene-LMR association.•Pyrene and tin regulated inflammation-related common genes in opposite directions.•8-OHdG mediated pyrene-LMR association and partially dependent on the dose of tin.</description><subject>Essential metals</subject><subject>Inflammation</subject><subject>Modification effect</subject><subject>Polycyclic aromatic hydrocarbons</subject><subject>Regulatory network</subject><issn>0269-7491</issn><issn>1873-6424</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2024</creationdate><recordtype>article</recordtype><recordid>eNp9kc1uFDEQhC0EIpvAGyDkI5dZ_O-ZCxKKAkSKxCWcLY_d1nqZsRd7NmifhZfFmwk5crLU_qqrWoXQO0q2lFD1cb-F9HDI05YRJraU8V6qF2hDe807JZh4iTaEqaHTYqAX6LLWPSFEcM5fo4vGSkUl26A_9zvAEAK4pWKbPD7kBdIS7YRncDubYp0rzgFDrc_zxU5tlvDStLbW7KJdYk6PXEt0cic3RYdtyXP7cHh38iU7W8Yz8zsuOzxOOXvsYJq60VbwOKYw2Xl-3INnW35CqW_Qq9Cc4O3Te4V-fLm5v_7W3X3_env9-a5znNKlU0EOTHAgcuwVAa21ImEESbSjg6aaDSPnrLeCKjlKwb3uqZeEWmvD4C3jV-jDuvdQ8q8j1MXMsZ6z2QT5WA0nbOipGnrSULGiruRaCwRzKLHFPRlKzLkWszdrLeZci1lrabL3Tw7HcQb_LPrXQwM-rQC0Ox8iFFNdhOTAx9KqMT7H_zv8BZUIo3k</recordid><startdate>20240515</startdate><enddate>20240515</enddate><creator>Liao, Xiaojing</creator><creator>Wu, Haimei</creator><creator>Liu, Kang</creator><creator>Bai, Yansen</creator><creator>Wu, Degang</creator><creator>Guo, Chaofan</creator><creator>Liu, Xin</creator><creator>Zhang, Zhaorui</creator><creator>Huang, Yongshun</creator><creator>Zhao, Na</creator><creator>Xiao, Yongmei</creator><creator>Deng, Qifei</creator><general>Elsevier Ltd</general><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7X8</scope><orcidid>https://orcid.org/0000-0002-2326-0468</orcidid></search><sort><creationdate>20240515</creationdate><title>The effects and potential mechanisms of essential metals on the associations of polycyclic aromatic hydrocarbons with blood cell-based inflammation markers</title><author>Liao, Xiaojing ; Wu, Haimei ; Liu, Kang ; Bai, Yansen ; Wu, Degang ; Guo, Chaofan ; Liu, Xin ; Zhang, Zhaorui ; Huang, Yongshun ; Zhao, Na ; Xiao, Yongmei ; Deng, Qifei</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c311t-6f59243e05b860e77760fbe507c1971729b3328a4165b543d781d501aaaf9da23</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2024</creationdate><topic>Essential metals</topic><topic>Inflammation</topic><topic>Modification effect</topic><topic>Polycyclic aromatic hydrocarbons</topic><topic>Regulatory network</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Liao, Xiaojing</creatorcontrib><creatorcontrib>Wu, Haimei</creatorcontrib><creatorcontrib>Liu, Kang</creatorcontrib><creatorcontrib>Bai, Yansen</creatorcontrib><creatorcontrib>Wu, Degang</creatorcontrib><creatorcontrib>Guo, Chaofan</creatorcontrib><creatorcontrib>Liu, Xin</creatorcontrib><creatorcontrib>Zhang, Zhaorui</creatorcontrib><creatorcontrib>Huang, Yongshun</creatorcontrib><creatorcontrib>Zhao, Na</creatorcontrib><creatorcontrib>Xiao, Yongmei</creatorcontrib><creatorcontrib>Deng, Qifei</creatorcontrib><collection>PubMed</collection><collection>CrossRef</collection><collection>MEDLINE - Academic</collection><jtitle>Environmental pollution (1987)</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Liao, Xiaojing</au><au>Wu, Haimei</au><au>Liu, Kang</au><au>Bai, Yansen</au><au>Wu, Degang</au><au>Guo, Chaofan</au><au>Liu, Xin</au><au>Zhang, Zhaorui</au><au>Huang, Yongshun</au><au>Zhao, Na</au><au>Xiao, Yongmei</au><au>Deng, Qifei</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>The effects and potential mechanisms of essential metals on the associations of polycyclic aromatic hydrocarbons with blood cell-based inflammation markers</atitle><jtitle>Environmental pollution (1987)</jtitle><addtitle>Environ Pollut</addtitle><date>2024-05-15</date><risdate>2024</risdate><volume>349</volume><spage>123856</spage><epage>123856</epage><pages>123856-123856</pages><artnum>123856</artnum><issn>0269-7491</issn><eissn>1873-6424</eissn><abstract>Polycyclic aromatic hydrocarbons (PAHs) are well-acknowledged pro-inflammatory chemicals, but their associations with blood cell-based inflammatory biomarkers need further investigation. Moreover, the effects and mechanisms of essential metals on PAH-related inflammation remain poorly understood.
To elucidate the associations of PAHs on inflammatory biomarkers, as well as the effects and mechanisms of essential metals on these associations.
A cross-sectional study was conducted on 1388 coke oven workers. We analyzed the modification effects of key essential metal(s) on PAHs-inflammatory biomarkers associations. To explore the possible mechanisms from an inflammation perspective, we performed a bioinformatic analysis on the genes of PAHs and essential metals obtained from the Comparative Toxicogenomics Database (CTD) and performed a mediation analysis.
We observed associations of PAHs and essential metals with lymphocyte-to-monocyte ratio (LMR) (P < 0.05). PAH mixtures were inversely associated with LMR (βQGC-index = −0.18, P < 0.001), with 1-hydroxypyrene (1-OH-Pyr) being the most prominent contributor (weight = 63.37%), whereas a positive association between essential metal mixtures and LMR was observed (βQGC-index = 0.14, P < 0.001), with tin being the most significant contributor (weight = 51.61%). An inverse association of 1-OH-Pyr with LMR was weakened by increased tin exposure (P < 0.05). The CTD database showed that PAHs and tin compounds co-regulated 22 inflammation-associated genes, but they regulated most genes in opposite directions. Further identified the involvement of oxidative stress and mediation analysis showed that the mediation effect of 8-hydroxydeoxyguanosine (8-OHdG) on 1-OH-Pyr-LMR association presented heterogeneity between low and high tin tertile groups (I2 = 37.84%).
1-OH-Pyr and tin were significantly associated with LMR. Modification effects indicated that the inverse association of 1-OH-Pyr with LMR was mitigated with an increase in tin. The mediation effect of 8-OHdG on the inverse association of 1-OH-Pyr with LMR may be partially dependent on tin.
[Display omitted]
•PAH mixtures were related to decreased LMR, with pyrene contributing the most.•Essential metals had joint effects on elevated LMR, with tin being predominant.•Tin had a modifying effect on pyrene-LMR association.•Pyrene and tin regulated inflammation-related common genes in opposite directions.•8-OHdG mediated pyrene-LMR association and partially dependent on the dose of tin.</abstract><cop>England</cop><pub>Elsevier Ltd</pub><pmid>38556152</pmid><doi>10.1016/j.envpol.2024.123856</doi><tpages>1</tpages><orcidid>https://orcid.org/0000-0002-2326-0468</orcidid></addata></record> |
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| ispartof | Environmental pollution (1987), 2024-05, Vol.349, p.123856-123856, Article 123856 |
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| language | eng |
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| source | Elsevier ScienceDirect Journals |
| subjects | Essential metals Inflammation Modification effect Polycyclic aromatic hydrocarbons Regulatory network |
| title | The effects and potential mechanisms of essential metals on the associations of polycyclic aromatic hydrocarbons with blood cell-based inflammation markers |
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