Precision Engineering of the Co‐immobilization of Enzymes for Cascade Biocatalysis

The design and orderly layered co‐immobilization of multiple enzymes on resin particles remain challenging. In this study, the SpyTag/SpyCatcher binding pair was fused to the N‐terminus of an alcohol dehydrogenase (ADH) and an aldo‐keto reductase (AKR), respectively. A non‐canonical amino acid (ncAA...

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Veröffentlicht in:	Angewandte Chemie International Edition 2024-05, Vol.63 (22), p.e202403539-n/a
Hauptverfasser:	Luo, Zhiyuan, Qiao, Li, Chen, Haomin, Mao, Zhili, Wu, Shujiao, Ma, Bianqin, Xie, Tian, Wang, Anming, Pei, Xiaolin, Sheldon, Roger A.
Format:	Artikel
Sprache:	eng
Schlagworte:	Alcohol dehydrogenase Alcohol Dehydrogenase - chemistry Alcohol Dehydrogenase - genetics Alcohol Dehydrogenase - metabolism Aldo-Keto Reductases - chemistry Aldo-Keto Reductases - genetics Aldo-Keto Reductases - metabolism Alkynes Amino acids asymmetric reduction Azides - chemistry Biocatalysis biological orthogonality Catalysis Catalytic converters Cycloaddition enzymatic cascades Enzymes Enzymes, Immobilized - chemistry Enzymes, Immobilized - metabolism Ethanol Immobilization Ketones Microspheres ordered immobilization Phenylalanine Phenylalanine - analogs & derivatives Phenylalanine - chemistry Phenylalanine - metabolism Protein Engineering Reactors Reductases
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