Laser Capture Microscopy RNA Sequencing for Topological Mapping of Synovial Pathology During Rheumatoid Arthritis

Objective Rheumatoid arthritis (RA) is an autoimmune disease in which the joint lining or synovium becomes highly inflamed and majorly contributes to disease progression. Understanding pathogenic processes in RA synovium is critical for identifying therapeutic targets. We performed laser capture mic...

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Veröffentlicht in:	Arthritis & rheumatology (Hoboken, N.J.) N.J.), 2024-08, Vol.76 (8), p.1243-1251
Hauptverfasser:	Van Espen, Benjamin, Prideaux, E. Barton, Wilson, Andrew R., Machado, Camilla R. L., Sendo, Sho, Parker, James, Seumois, Grégory, Sacchetti, Cristiano, Belongia, Anna C., Perumal, Narayanan B., Vijayanand, Pandurangan, Linnik, Matthew D., Benschop, Robert J., Wang, Wei, Bottini, Nunzio, Firestein, Gary S., Stanford, Stephanie M.
Format:	Artikel
Sprache:	eng
Schlagworte:	Abnormalities Aged Arthritis Arthritis, Rheumatoid - genetics Arthritis, Rheumatoid - pathology Autoimmune diseases Cell cycle Cell signaling Cluster analysis Clustering Female Gene expression Gene Expression Profiling Gene sequencing Humans Immune system Inflammation Laser Capture Microdissection Male Microscopy Middle Aged Osteoarthritis Osteoarthritis - genetics Osteoarthritis - pathology Pattern analysis Principal Component Analysis Principal components analysis Rheumatoid arthritis Rheumatoid synovitis Ribonucleic acid RNA Scavenging Sequence Analysis, RNA Synovial Membrane - metabolism Synovial Membrane - pathology Therapeutic targets Topology Transcriptome Transcriptomes Vessels
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