A healthy dietary pattern is associated with microbiota diversity in recently diagnosed bipolar patients: The Bipolar Netherlands Cohort (BINCO) study
Diet largely impacts the gut microbiota, and may affect mental and somatic health via the gut-brain axis. As such, the relationship between diet and the microbiota in Bipolar Disorder (BD) could be of importance, but has not been studied before. The aim was therefore to assess whether dietary qualit...
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| Veröffentlicht in: | Journal of affective disorders 2024-06, Vol.355, p.157-166 |
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| creator | Riedinger, M.A. Mesbah, R. Koenders, M. Henderickx, J.G.E. Smits, W.K. El Filali, E. Geleijnse, J.M. van der Wee, N.J.A. de Leeuw, M. Giltay, E.J. |
| description | Diet largely impacts the gut microbiota, and may affect mental and somatic health via the gut-brain axis. As such, the relationship between diet and the microbiota in Bipolar Disorder (BD) could be of importance, but has not been studied before. The aim was therefore to assess whether dietary quality is associated with the gut microbiota diversity in patients with recently diagnosed BD, and whether changes occur in dietary quality and microbiota diversity during their first year of treatment.
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| doi_str_mv | 10.1016/j.jad.2024.03.105 |
| format | Article |
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Seventy recently (<1 year) diagnosed patients with BD were included in the “Bipolar Netherlands Cohort” (BINCO), and a total of 45 participants were assessed after one year. A 203-item Food Frequency Questionnaire (FFQ) data yielded the Dutch Healthy index (DHD-15), and the microbiota composition and diversity of fecal samples were characterized by 16S rRNA gene amplicon sequencing at baseline and 1-year follow-up. Associations and changes over time were analyzed using multivariate regression analyses and t-tests for paired samples.
Included patients had a mean age of 34.9 years (SD ± 11.2), and 58.6 % was female. Alpha diversity (Shannon diversity index), richness (Chao1 index) and evenness (Pielou's Evenness Index) were positively associated with the DHD-15 total score, after adjustment for sex, age and educational level (beta = 0.55; P < 0.001, beta = 0.39; P = 0.024, beta = 0.54; P = 0.001 respectively). The positive correlations were largely driven by the combined positive effect of fish, beans, fruits and nuts, and inverse correlations with alcohol and processed meats. No significant changes were found in DHD-15 total score, nor in microbiota diversity, richness and evenness indexes during one year follow-up and regular treatment.
A healthy and varied diet is associated with the diversity of the microbiota in BD patients. Its potential consequences for maintaining mood stability and overall health should be studied further.
•A healthier diet was associated with higher diversity and richness of microbiota in recently diagnosed BD patients.•Overall dietary quality did not change significantly during one year follow-up in recently diagnosed BD patients.•Microbiota diversity did not change significantly during one year of follow-up in recently diagnosed BD patients.</description><identifier>ISSN: 0165-0327</identifier><identifier>EISSN: 1573-2517</identifier><identifier>DOI: 10.1016/j.jad.2024.03.105</identifier><identifier>PMID: 38527529</identifier><language>eng</language><publisher>Netherlands: Elsevier B.V</publisher><subject>Adult ; Bipolar Disorder ; Diet ; Dietary Patterns ; Dietary quality ; Female ; Gastrointestinal Microbiome - genetics ; Gut ; Healthy diet ; Humans ; Microbiota ; Netherlands ; RNA, Ribosomal, 16S - genetics</subject><ispartof>Journal of affective disorders, 2024-06, Vol.355, p.157-166</ispartof><rights>2024 The Authors</rights><rights>Copyright © 2024 The Authors. Published by Elsevier B.V. All rights reserved.</rights><lds50>peer_reviewed</lds50><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed><cites>FETCH-LOGICAL-c348t-11bdd48a8cdf35a4cc80124ba7d77f8aa5321e18432d09fcb1c6c35404f821e93</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktohtml>$$Uhttps://dx.doi.org/10.1016/j.jad.2024.03.105$$EHTML$$P50$$Gelsevier$$Hfree_for_read</linktohtml><link.rule.ids>314,777,781,3537,27905,27906,45976</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/38527529$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Riedinger, M.A.</creatorcontrib><creatorcontrib>Mesbah, R.</creatorcontrib><creatorcontrib>Koenders, M.</creatorcontrib><creatorcontrib>Henderickx, J.G.E.</creatorcontrib><creatorcontrib>Smits, W.K.</creatorcontrib><creatorcontrib>El Filali, E.</creatorcontrib><creatorcontrib>Geleijnse, J.M.</creatorcontrib><creatorcontrib>van der Wee, N.J.A.</creatorcontrib><creatorcontrib>de Leeuw, M.</creatorcontrib><creatorcontrib>Giltay, E.J.</creatorcontrib><title>A healthy dietary pattern is associated with microbiota diversity in recently diagnosed bipolar patients: The Bipolar Netherlands Cohort (BINCO) study</title><title>Journal of affective disorders</title><addtitle>J Affect Disord</addtitle><description>Diet largely impacts the gut microbiota, and may affect mental and somatic health via the gut-brain axis. As such, the relationship between diet and the microbiota in Bipolar Disorder (BD) could be of importance, but has not been studied before. The aim was therefore to assess whether dietary quality is associated with the gut microbiota diversity in patients with recently diagnosed BD, and whether changes occur in dietary quality and microbiota diversity during their first year of treatment.
Seventy recently (<1 year) diagnosed patients with BD were included in the “Bipolar Netherlands Cohort” (BINCO), and a total of 45 participants were assessed after one year. A 203-item Food Frequency Questionnaire (FFQ) data yielded the Dutch Healthy index (DHD-15), and the microbiota composition and diversity of fecal samples were characterized by 16S rRNA gene amplicon sequencing at baseline and 1-year follow-up. Associations and changes over time were analyzed using multivariate regression analyses and t-tests for paired samples.
Included patients had a mean age of 34.9 years (SD ± 11.2), and 58.6 % was female. Alpha diversity (Shannon diversity index), richness (Chao1 index) and evenness (Pielou's Evenness Index) were positively associated with the DHD-15 total score, after adjustment for sex, age and educational level (beta = 0.55; P < 0.001, beta = 0.39; P = 0.024, beta = 0.54; P = 0.001 respectively). The positive correlations were largely driven by the combined positive effect of fish, beans, fruits and nuts, and inverse correlations with alcohol and processed meats. No significant changes were found in DHD-15 total score, nor in microbiota diversity, richness and evenness indexes during one year follow-up and regular treatment.
A healthy and varied diet is associated with the diversity of the microbiota in BD patients. Its potential consequences for maintaining mood stability and overall health should be studied further.
•A healthier diet was associated with higher diversity and richness of microbiota in recently diagnosed BD patients.•Overall dietary quality did not change significantly during one year follow-up in recently diagnosed BD patients.•Microbiota diversity did not change significantly during one year of follow-up in recently diagnosed BD patients.</description><subject>Adult</subject><subject>Bipolar Disorder</subject><subject>Diet</subject><subject>Dietary Patterns</subject><subject>Dietary quality</subject><subject>Female</subject><subject>Gastrointestinal Microbiome - genetics</subject><subject>Gut</subject><subject>Healthy diet</subject><subject>Humans</subject><subject>Microbiota</subject><subject>Netherlands</subject><subject>RNA, Ribosomal, 16S - genetics</subject><issn>0165-0327</issn><issn>1573-2517</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2024</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNp9kc1uEzEUhS0EomnhAdggL9vFBP-MMx5YpVEplap2U9aWx77DOJqMg-20yovwvNwogWVXls797pHvOYR84mzOGV98Wc_X1s8FE_WcSZTUGzLjqpGVULx5S2bIqIpJ0ZyR85zXjLFF27D35ExqJRol2hn5s6QD2LEMe-oDFJv2dGtLgTTRkKnNObpgC3j6EspAN8Gl2IVYLNLPkHIoexommsDBVMaDh_01xYx8F7ZxtOngFnCWv9KnAej1SX2AMkAa7eQzXcUhpkIvr-8eVo9XNJed338g73o7Zvh4ei_Iz-83T6sf1f3j7d1qeV85WetScd55X2urne-lsrVzmnFRd7bxTdNra5UUHLiupfCs7V3H3cJJVbO61zho5QW5PPpuU_y9g1zMJmQHI_4M4i4byUSrMUXJEOVHFCPIOUFvtilsMDDDmTnUYdYG6zCHOgyTKCnc-Xyy33Ub8P83_uWPwLcjAHjkc4BkssO4HPiAmRbjY3jF_i9JA50i</recordid><startdate>20240615</startdate><enddate>20240615</enddate><creator>Riedinger, M.A.</creator><creator>Mesbah, R.</creator><creator>Koenders, M.</creator><creator>Henderickx, J.G.E.</creator><creator>Smits, W.K.</creator><creator>El Filali, E.</creator><creator>Geleijnse, J.M.</creator><creator>van der Wee, N.J.A.</creator><creator>de Leeuw, M.</creator><creator>Giltay, E.J.</creator><general>Elsevier B.V</general><scope>6I.</scope><scope>AAFTH</scope><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7X8</scope></search><sort><creationdate>20240615</creationdate><title>A healthy dietary pattern is associated with microbiota diversity in recently diagnosed bipolar patients: The Bipolar Netherlands Cohort (BINCO) study</title><author>Riedinger, M.A. ; Mesbah, R. ; Koenders, M. ; Henderickx, J.G.E. ; Smits, W.K. ; El Filali, E. ; Geleijnse, J.M. ; van der Wee, N.J.A. ; de Leeuw, M. ; Giltay, E.J.</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c348t-11bdd48a8cdf35a4cc80124ba7d77f8aa5321e18432d09fcb1c6c35404f821e93</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2024</creationdate><topic>Adult</topic><topic>Bipolar Disorder</topic><topic>Diet</topic><topic>Dietary Patterns</topic><topic>Dietary quality</topic><topic>Female</topic><topic>Gastrointestinal Microbiome - genetics</topic><topic>Gut</topic><topic>Healthy diet</topic><topic>Humans</topic><topic>Microbiota</topic><topic>Netherlands</topic><topic>RNA, Ribosomal, 16S - genetics</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Riedinger, M.A.</creatorcontrib><creatorcontrib>Mesbah, R.</creatorcontrib><creatorcontrib>Koenders, M.</creatorcontrib><creatorcontrib>Henderickx, J.G.E.</creatorcontrib><creatorcontrib>Smits, W.K.</creatorcontrib><creatorcontrib>El Filali, E.</creatorcontrib><creatorcontrib>Geleijnse, J.M.</creatorcontrib><creatorcontrib>van der Wee, N.J.A.</creatorcontrib><creatorcontrib>de Leeuw, M.</creatorcontrib><creatorcontrib>Giltay, E.J.</creatorcontrib><collection>ScienceDirect Open Access Titles</collection><collection>Elsevier:ScienceDirect:Open Access</collection><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>MEDLINE - Academic</collection><jtitle>Journal of affective disorders</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Riedinger, M.A.</au><au>Mesbah, R.</au><au>Koenders, M.</au><au>Henderickx, J.G.E.</au><au>Smits, W.K.</au><au>El Filali, E.</au><au>Geleijnse, J.M.</au><au>van der Wee, N.J.A.</au><au>de Leeuw, M.</au><au>Giltay, E.J.</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>A healthy dietary pattern is associated with microbiota diversity in recently diagnosed bipolar patients: The Bipolar Netherlands Cohort (BINCO) study</atitle><jtitle>Journal of affective disorders</jtitle><addtitle>J Affect Disord</addtitle><date>2024-06-15</date><risdate>2024</risdate><volume>355</volume><spage>157</spage><epage>166</epage><pages>157-166</pages><issn>0165-0327</issn><eissn>1573-2517</eissn><abstract>Diet largely impacts the gut microbiota, and may affect mental and somatic health via the gut-brain axis. As such, the relationship between diet and the microbiota in Bipolar Disorder (BD) could be of importance, but has not been studied before. The aim was therefore to assess whether dietary quality is associated with the gut microbiota diversity in patients with recently diagnosed BD, and whether changes occur in dietary quality and microbiota diversity during their first year of treatment.
Seventy recently (<1 year) diagnosed patients with BD were included in the “Bipolar Netherlands Cohort” (BINCO), and a total of 45 participants were assessed after one year. A 203-item Food Frequency Questionnaire (FFQ) data yielded the Dutch Healthy index (DHD-15), and the microbiota composition and diversity of fecal samples were characterized by 16S rRNA gene amplicon sequencing at baseline and 1-year follow-up. Associations and changes over time were analyzed using multivariate regression analyses and t-tests for paired samples.
Included patients had a mean age of 34.9 years (SD ± 11.2), and 58.6 % was female. Alpha diversity (Shannon diversity index), richness (Chao1 index) and evenness (Pielou's Evenness Index) were positively associated with the DHD-15 total score, after adjustment for sex, age and educational level (beta = 0.55; P < 0.001, beta = 0.39; P = 0.024, beta = 0.54; P = 0.001 respectively). The positive correlations were largely driven by the combined positive effect of fish, beans, fruits and nuts, and inverse correlations with alcohol and processed meats. No significant changes were found in DHD-15 total score, nor in microbiota diversity, richness and evenness indexes during one year follow-up and regular treatment.
A healthy and varied diet is associated with the diversity of the microbiota in BD patients. Its potential consequences for maintaining mood stability and overall health should be studied further.
•A healthier diet was associated with higher diversity and richness of microbiota in recently diagnosed BD patients.•Overall dietary quality did not change significantly during one year follow-up in recently diagnosed BD patients.•Microbiota diversity did not change significantly during one year of follow-up in recently diagnosed BD patients.</abstract><cop>Netherlands</cop><pub>Elsevier B.V</pub><pmid>38527529</pmid><doi>10.1016/j.jad.2024.03.105</doi><tpages>10</tpages><oa>free_for_read</oa></addata></record> |
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| subjects | Adult Bipolar Disorder Diet Dietary Patterns Dietary quality Female Gastrointestinal Microbiome - genetics Gut Healthy diet Humans Microbiota Netherlands RNA, Ribosomal, 16S - genetics |
| title | A healthy dietary pattern is associated with microbiota diversity in recently diagnosed bipolar patients: The Bipolar Netherlands Cohort (BINCO) study |
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