Association between polyunsaturated fatty acids in adipose tissue and mortality of colorectal cancer patients
[Display omitted] •WHAT IS KNOWNNutritional intake and FA metabolism play a role in the progression of tumors.Biomarkers allow objective assessments of intake, storage and bioavailability.The influence of PUFAs from adipose tissue on CRC mortality is not documented.•WHAT IS NEW HERESome n-6 PUFAs we...
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| creator | Roux-Levy, Cécile Binquet, Christine Vaysse, Carole Scherrer, Marie-Lorraine Ayav, Ahmet Ortega-Deballon, Pablo Lakkis, Zaher Liu, David Deguelte, Sophie Cottet, Vanessa |
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•WHAT IS KNOWNNutritional intake and FA metabolism play a role in the progression of tumors.Biomarkers allow objective assessments of intake, storage and bioavailability.The influence of PUFAs from adipose tissue on CRC mortality is not documented.•WHAT IS NEW HERESome n-6 PUFAs were positively associated with all-cause mortality in CRC patients.ALA was negatively associated with all-cause mortality in CRC patients.
Nutritional intake and dysregulation of fatty acid metabolism play a role in the progression of various tumors, but the consumption of fatty acids is difficult to assess accurately with dietary questionnaires. Biomarkers can objectively assess intake, storage and bioavailability.
We studied the association between the polyunsaturated fatty acid (PUFA) composition of abdominal subcutaneous adipose tissue (good indicator of dietary intake over 2–3 years) and all-cause mortality.
In the multicenter AGARIC study, samples from 203 patients with colorectal cancer (CRC) undergoing curative surgery, were harvested from subcutaneous adipose tissue, which were then analyzed for PUFA composition.
After a median follow-up of 45 months, 76 patients died. These patients were more often men (72.4% versus 57.5%, P = 0.04), diabetic (32.9% versus 13.4%, P = 0.001), old (median: 74.5 versus 66.6 years, P < 0.001) and with high alcohol consumption (47.4% versus 30.7%, P = 0.005). An increased risk of death was observed with higher levels of 20:2 ω-6 (hazard ratiotertile3 vstertile1 (HRT3vsT1) 2.12; 95% confidence interval (CI) 1.01–4.42; p-trend = 0.04), 22:4 ω-6 (HRT3vsT1 = 3.52; 95% CI = 1.51–8.17; p-trend = 0.005), and 22:5 ω-6 (HRT3vsT1 = 3.50; 95% CI = 1.56–7.87; p-trend = 0.002). Conversely, the risk of death seemed lower when higher concentrations of 18:3 ω-6 (HRT3vsT1 = 0.52; 95% CI = 0.27–0.99; p-trend = 0.04) and the essential fatty acid, α-linolenic acid 18:3 ω-3 (HRT3vsT1 = 0.47; 95% CI = 0.24–0.93; p-trend = 0.03) were observed.
The risk of death was increased in CRC patients with higher concentrations of certain ω-6 PUFAs and lower concentrations of α-linolenic acid in their subcutaneous adipose tissue. These results reflect dietary habits and altered fatty acid metabolism. Our exploratory results warrant confirmation in larger studies with further exploration of the mechanisms involved. |
| doi_str_mv | 10.1016/j.nut.2024.112358 |
| format | Article |
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•WHAT IS KNOWNNutritional intake and FA metabolism play a role in the progression of tumors.Biomarkers allow objective assessments of intake, storage and bioavailability.The influence of PUFAs from adipose tissue on CRC mortality is not documented.•WHAT IS NEW HERESome n-6 PUFAs were positively associated with all-cause mortality in CRC patients.ALA was negatively associated with all-cause mortality in CRC patients.
Nutritional intake and dysregulation of fatty acid metabolism play a role in the progression of various tumors, but the consumption of fatty acids is difficult to assess accurately with dietary questionnaires. Biomarkers can objectively assess intake, storage and bioavailability.
We studied the association between the polyunsaturated fatty acid (PUFA) composition of abdominal subcutaneous adipose tissue (good indicator of dietary intake over 2–3 years) and all-cause mortality.
In the multicenter AGARIC study, samples from 203 patients with colorectal cancer (CRC) undergoing curative surgery, were harvested from subcutaneous adipose tissue, which were then analyzed for PUFA composition.
After a median follow-up of 45 months, 76 patients died. These patients were more often men (72.4% versus 57.5%, P = 0.04), diabetic (32.9% versus 13.4%, P = 0.001), old (median: 74.5 versus 66.6 years, P < 0.001) and with high alcohol consumption (47.4% versus 30.7%, P = 0.005). An increased risk of death was observed with higher levels of 20:2 ω-6 (hazard ratiotertile3 vstertile1 (HRT3vsT1) 2.12; 95% confidence interval (CI) 1.01–4.42; p-trend = 0.04), 22:4 ω-6 (HRT3vsT1 = 3.52; 95% CI = 1.51–8.17; p-trend = 0.005), and 22:5 ω-6 (HRT3vsT1 = 3.50; 95% CI = 1.56–7.87; p-trend = 0.002). Conversely, the risk of death seemed lower when higher concentrations of 18:3 ω-6 (HRT3vsT1 = 0.52; 95% CI = 0.27–0.99; p-trend = 0.04) and the essential fatty acid, α-linolenic acid 18:3 ω-3 (HRT3vsT1 = 0.47; 95% CI = 0.24–0.93; p-trend = 0.03) were observed.
The risk of death was increased in CRC patients with higher concentrations of certain ω-6 PUFAs and lower concentrations of α-linolenic acid in their subcutaneous adipose tissue. These results reflect dietary habits and altered fatty acid metabolism. Our exploratory results warrant confirmation in larger studies with further exploration of the mechanisms involved.</description><identifier>ISSN: 0899-9007</identifier><identifier>EISSN: 1873-1244</identifier><identifier>DOI: 10.1016/j.nut.2024.112358</identifier><identifier>PMID: 38401197</identifier><language>eng</language><publisher>United States: Elsevier Inc</publisher><subject>Adipose Tissue ; Alcohol use ; alpha-Linolenic Acid ; Bioavailability ; Biobanks ; Biomarkers ; Body fat ; Cancer ; Cancer therapies ; Chromatography ; Colorectal cancer ; Colorectal carcinoma ; Colorectal Neoplasms - surgery ; Composition ; Death ; Diabetes mellitus ; Diet ; Dietary intake ; Exercise ; Fatty Acids ; Fatty Acids, Omega-3 ; Fatty Acids, Unsaturated ; Food intake ; Humans ; Linolenic acid ; Lipids ; Male ; Medical prognosis ; Metabolism ; Metastasis ; Mortality ; polyunsaturated fatty acid ; Polyunsaturated fatty acids ; prognosis ; Risk ; Tissues</subject><ispartof>Nutrition (Burbank, Los Angeles County, Calif.), 2024-05, Vol.121, p.112358-112358, Article 112358</ispartof><rights>2024 Elsevier Inc.</rights><rights>Copyright © 2024 Elsevier Inc. All rights reserved.</rights><rights>2024. Elsevier Inc.</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><cites>FETCH-LOGICAL-c333t-8495b90eba5a5a73cfafcfe094a8d6996dfb87c85cc630f900e3784987f88e693</cites><orcidid>0000-0002-9417-5754 ; 0000-0001-8546-0433 ; 0000-0002-2608-5896 ; 0000-0002-3114-8425 ; 0000-0001-7874-7743</orcidid></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktohtml>$$Uhttps://www.proquest.com/docview/3005148355?pq-origsite=primo$$EHTML$$P50$$Gproquest$$H</linktohtml><link.rule.ids>314,780,784,3550,27924,27925,45995,64385,64387,64389,72469</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/38401197$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Roux-Levy, Cécile</creatorcontrib><creatorcontrib>Binquet, Christine</creatorcontrib><creatorcontrib>Vaysse, Carole</creatorcontrib><creatorcontrib>Scherrer, Marie-Lorraine</creatorcontrib><creatorcontrib>Ayav, Ahmet</creatorcontrib><creatorcontrib>Ortega-Deballon, Pablo</creatorcontrib><creatorcontrib>Lakkis, Zaher</creatorcontrib><creatorcontrib>Liu, David</creatorcontrib><creatorcontrib>Deguelte, Sophie</creatorcontrib><creatorcontrib>Cottet, Vanessa</creatorcontrib><title>Association between polyunsaturated fatty acids in adipose tissue and mortality of colorectal cancer patients</title><title>Nutrition (Burbank, Los Angeles County, Calif.)</title><addtitle>Nutrition</addtitle><description>[Display omitted]
•WHAT IS KNOWNNutritional intake and FA metabolism play a role in the progression of tumors.Biomarkers allow objective assessments of intake, storage and bioavailability.The influence of PUFAs from adipose tissue on CRC mortality is not documented.•WHAT IS NEW HERESome n-6 PUFAs were positively associated with all-cause mortality in CRC patients.ALA was negatively associated with all-cause mortality in CRC patients.
Nutritional intake and dysregulation of fatty acid metabolism play a role in the progression of various tumors, but the consumption of fatty acids is difficult to assess accurately with dietary questionnaires. Biomarkers can objectively assess intake, storage and bioavailability.
We studied the association between the polyunsaturated fatty acid (PUFA) composition of abdominal subcutaneous adipose tissue (good indicator of dietary intake over 2–3 years) and all-cause mortality.
In the multicenter AGARIC study, samples from 203 patients with colorectal cancer (CRC) undergoing curative surgery, were harvested from subcutaneous adipose tissue, which were then analyzed for PUFA composition.
After a median follow-up of 45 months, 76 patients died. These patients were more often men (72.4% versus 57.5%, P = 0.04), diabetic (32.9% versus 13.4%, P = 0.001), old (median: 74.5 versus 66.6 years, P < 0.001) and with high alcohol consumption (47.4% versus 30.7%, P = 0.005). An increased risk of death was observed with higher levels of 20:2 ω-6 (hazard ratiotertile3 vstertile1 (HRT3vsT1) 2.12; 95% confidence interval (CI) 1.01–4.42; p-trend = 0.04), 22:4 ω-6 (HRT3vsT1 = 3.52; 95% CI = 1.51–8.17; p-trend = 0.005), and 22:5 ω-6 (HRT3vsT1 = 3.50; 95% CI = 1.56–7.87; p-trend = 0.002). Conversely, the risk of death seemed lower when higher concentrations of 18:3 ω-6 (HRT3vsT1 = 0.52; 95% CI = 0.27–0.99; p-trend = 0.04) and the essential fatty acid, α-linolenic acid 18:3 ω-3 (HRT3vsT1 = 0.47; 95% CI = 0.24–0.93; p-trend = 0.03) were observed.
The risk of death was increased in CRC patients with higher concentrations of certain ω-6 PUFAs and lower concentrations of α-linolenic acid in their subcutaneous adipose tissue. These results reflect dietary habits and altered fatty acid metabolism. Our exploratory results warrant confirmation in larger studies with further exploration of the mechanisms involved.</description><subject>Adipose Tissue</subject><subject>Alcohol use</subject><subject>alpha-Linolenic Acid</subject><subject>Bioavailability</subject><subject>Biobanks</subject><subject>Biomarkers</subject><subject>Body fat</subject><subject>Cancer</subject><subject>Cancer therapies</subject><subject>Chromatography</subject><subject>Colorectal cancer</subject><subject>Colorectal carcinoma</subject><subject>Colorectal Neoplasms - surgery</subject><subject>Composition</subject><subject>Death</subject><subject>Diabetes mellitus</subject><subject>Diet</subject><subject>Dietary intake</subject><subject>Exercise</subject><subject>Fatty Acids</subject><subject>Fatty Acids, Omega-3</subject><subject>Fatty Acids, Unsaturated</subject><subject>Food intake</subject><subject>Humans</subject><subject>Linolenic acid</subject><subject>Lipids</subject><subject>Male</subject><subject>Medical prognosis</subject><subject>Metabolism</subject><subject>Metastasis</subject><subject>Mortality</subject><subject>polyunsaturated fatty acid</subject><subject>Polyunsaturated fatty acids</subject><subject>prognosis</subject><subject>Risk</subject><subject>Tissues</subject><issn>0899-9007</issn><issn>1873-1244</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2024</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><sourceid>8G5</sourceid><sourceid>ABUWG</sourceid><sourceid>AFKRA</sourceid><sourceid>AZQEC</sourceid><sourceid>BENPR</sourceid><sourceid>CCPQU</sourceid><sourceid>DWQXO</sourceid><sourceid>GNUQQ</sourceid><sourceid>GUQSH</sourceid><sourceid>M2O</sourceid><recordid>eNp9kUFrHSEUhaW0NC9Jf0A3Regmm3nVcRyVrkJI00Kgm2Ytjl7Bx4xO1Wl5_z4-XtpFF8XFBfnO4d5zEHpPyZ4SOn467ONW9z3phz2lPePyFdpRKVhH-2F4jXZEKtUpQsQFuizlQAihalRv0QWTA6FUiR1abktJNpgaUsQT1N8AEa9pPm6xmLplU8Fhb2o9YmODKzhEbFxYUwFcQykbYBMdXlKuZg6NSh7bNKcMtn1ga6KFjNfmD7GWa_TGm7nAu5d5hZ6-3P-4-9o9fn_4dnf72FnGWO3koPikCEyGtyeY9cZbD0QNRrpRqdH5SQorubUjI75dCEw0kRReShgVu0I3Z981p58blKqXUCzMs4mQtqIZ6XsuBCe0oR__QQ9py7Ft1yjC6SAZ542iZ8rmVEoGr9ccFpOPmhJ96kIfdOtCn7rQ5y6a5sOL8zYt4P4q_oTfgM9nAFoUvwJkXWyLyYILp_i0S-E_9s9o6puO</recordid><startdate>202405</startdate><enddate>202405</enddate><creator>Roux-Levy, Cécile</creator><creator>Binquet, Christine</creator><creator>Vaysse, Carole</creator><creator>Scherrer, Marie-Lorraine</creator><creator>Ayav, Ahmet</creator><creator>Ortega-Deballon, Pablo</creator><creator>Lakkis, Zaher</creator><creator>Liu, David</creator><creator>Deguelte, Sophie</creator><creator>Cottet, Vanessa</creator><general>Elsevier Inc</general><general>Elsevier 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between polyunsaturated fatty acids in adipose tissue and mortality of colorectal cancer patients</title><author>Roux-Levy, Cécile ; Binquet, Christine ; Vaysse, Carole ; Scherrer, Marie-Lorraine ; Ayav, Ahmet ; Ortega-Deballon, Pablo ; Lakkis, Zaher ; Liu, David ; Deguelte, Sophie ; Cottet, Vanessa</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c333t-8495b90eba5a5a73cfafcfe094a8d6996dfb87c85cc630f900e3784987f88e693</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2024</creationdate><topic>Adipose Tissue</topic><topic>Alcohol use</topic><topic>alpha-Linolenic Acid</topic><topic>Bioavailability</topic><topic>Biobanks</topic><topic>Biomarkers</topic><topic>Body fat</topic><topic>Cancer</topic><topic>Cancer therapies</topic><topic>Chromatography</topic><topic>Colorectal cancer</topic><topic>Colorectal carcinoma</topic><topic>Colorectal Neoplasms - surgery</topic><topic>Composition</topic><topic>Death</topic><topic>Diabetes mellitus</topic><topic>Diet</topic><topic>Dietary intake</topic><topic>Exercise</topic><topic>Fatty Acids</topic><topic>Fatty Acids, Omega-3</topic><topic>Fatty Acids, Unsaturated</topic><topic>Food intake</topic><topic>Humans</topic><topic>Linolenic acid</topic><topic>Lipids</topic><topic>Male</topic><topic>Medical prognosis</topic><topic>Metabolism</topic><topic>Metastasis</topic><topic>Mortality</topic><topic>polyunsaturated fatty acid</topic><topic>Polyunsaturated fatty acids</topic><topic>prognosis</topic><topic>Risk</topic><topic>Tissues</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Roux-Levy, Cécile</creatorcontrib><creatorcontrib>Binquet, Christine</creatorcontrib><creatorcontrib>Vaysse, Carole</creatorcontrib><creatorcontrib>Scherrer, Marie-Lorraine</creatorcontrib><creatorcontrib>Ayav, Ahmet</creatorcontrib><creatorcontrib>Ortega-Deballon, 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County, Calif.)</jtitle><addtitle>Nutrition</addtitle><date>2024-05</date><risdate>2024</risdate><volume>121</volume><spage>112358</spage><epage>112358</epage><pages>112358-112358</pages><artnum>112358</artnum><issn>0899-9007</issn><eissn>1873-1244</eissn><abstract>[Display omitted]
•WHAT IS KNOWNNutritional intake and FA metabolism play a role in the progression of tumors.Biomarkers allow objective assessments of intake, storage and bioavailability.The influence of PUFAs from adipose tissue on CRC mortality is not documented.•WHAT IS NEW HERESome n-6 PUFAs were positively associated with all-cause mortality in CRC patients.ALA was negatively associated with all-cause mortality in CRC patients.
Nutritional intake and dysregulation of fatty acid metabolism play a role in the progression of various tumors, but the consumption of fatty acids is difficult to assess accurately with dietary questionnaires. Biomarkers can objectively assess intake, storage and bioavailability.
We studied the association between the polyunsaturated fatty acid (PUFA) composition of abdominal subcutaneous adipose tissue (good indicator of dietary intake over 2–3 years) and all-cause mortality.
In the multicenter AGARIC study, samples from 203 patients with colorectal cancer (CRC) undergoing curative surgery, were harvested from subcutaneous adipose tissue, which were then analyzed for PUFA composition.
After a median follow-up of 45 months, 76 patients died. These patients were more often men (72.4% versus 57.5%, P = 0.04), diabetic (32.9% versus 13.4%, P = 0.001), old (median: 74.5 versus 66.6 years, P < 0.001) and with high alcohol consumption (47.4% versus 30.7%, P = 0.005). An increased risk of death was observed with higher levels of 20:2 ω-6 (hazard ratiotertile3 vstertile1 (HRT3vsT1) 2.12; 95% confidence interval (CI) 1.01–4.42; p-trend = 0.04), 22:4 ω-6 (HRT3vsT1 = 3.52; 95% CI = 1.51–8.17; p-trend = 0.005), and 22:5 ω-6 (HRT3vsT1 = 3.50; 95% CI = 1.56–7.87; p-trend = 0.002). Conversely, the risk of death seemed lower when higher concentrations of 18:3 ω-6 (HRT3vsT1 = 0.52; 95% CI = 0.27–0.99; p-trend = 0.04) and the essential fatty acid, α-linolenic acid 18:3 ω-3 (HRT3vsT1 = 0.47; 95% CI = 0.24–0.93; p-trend = 0.03) were observed.
The risk of death was increased in CRC patients with higher concentrations of certain ω-6 PUFAs and lower concentrations of α-linolenic acid in their subcutaneous adipose tissue. These results reflect dietary habits and altered fatty acid metabolism. Our exploratory results warrant confirmation in larger studies with further exploration of the mechanisms involved.</abstract><cop>United States</cop><pub>Elsevier Inc</pub><pmid>38401197</pmid><doi>10.1016/j.nut.2024.112358</doi><tpages>1</tpages><orcidid>https://orcid.org/0000-0002-9417-5754</orcidid><orcidid>https://orcid.org/0000-0001-8546-0433</orcidid><orcidid>https://orcid.org/0000-0002-2608-5896</orcidid><orcidid>https://orcid.org/0000-0002-3114-8425</orcidid><orcidid>https://orcid.org/0000-0001-7874-7743</orcidid></addata></record> |
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| ispartof | Nutrition (Burbank, Los Angeles County, Calif.), 2024-05, Vol.121, p.112358-112358, Article 112358 |
| issn | 0899-9007 1873-1244 |
| language | eng |
| recordid | cdi_proquest_miscellaneous_3022577501 |
| source | MEDLINE; Access via ScienceDirect (Elsevier); ProQuest Central UK/Ireland |
| subjects | Adipose Tissue Alcohol use alpha-Linolenic Acid Bioavailability Biobanks Biomarkers Body fat Cancer Cancer therapies Chromatography Colorectal cancer Colorectal carcinoma Colorectal Neoplasms - surgery Composition Death Diabetes mellitus Diet Dietary intake Exercise Fatty Acids Fatty Acids, Omega-3 Fatty Acids, Unsaturated Food intake Humans Linolenic acid Lipids Male Medical prognosis Metabolism Metastasis Mortality polyunsaturated fatty acid Polyunsaturated fatty acids prognosis Risk Tissues |
| title | Association between polyunsaturated fatty acids in adipose tissue and mortality of colorectal cancer patients |
| url | https://sfx.bib-bvb.de/sfx_tum?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&ctx_tim=2024-12-28T01%3A21%3A29IST&url_ver=Z39.88-2004&url_ctx_fmt=infofi/fmt:kev:mtx:ctx&rfr_id=info:sid/primo.exlibrisgroup.com:primo3-Article-proquest_cross&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.atitle=Association%20between%20polyunsaturated%20fatty%20acids%20in%20adipose%20tissue%20and%20mortality%20of%20colorectal%20cancer%20patients&rft.jtitle=Nutrition%20(Burbank,%20Los%20Angeles%20County,%20Calif.)&rft.au=Roux-Levy,%20C%C3%A9cile&rft.date=2024-05&rft.volume=121&rft.spage=112358&rft.epage=112358&rft.pages=112358-112358&rft.artnum=112358&rft.issn=0899-9007&rft.eissn=1873-1244&rft_id=info:doi/10.1016/j.nut.2024.112358&rft_dat=%3Cproquest_cross%3E3005148355%3C/proquest_cross%3E%3Curl%3E%3C/url%3E&disable_directlink=true&sfx.directlink=off&sfx.report_link=0&rft_id=info:oai/&rft_pqid=3005148355&rft_id=info:pmid/38401197&rft_els_id=S089990072400008X&rfr_iscdi=true |