MRI Extracellular Volume Fraction in Liver Fibrosis—A Comparison of Different Time Points and Blood Pool Measurements
Background Extracellular volume (ECV) correlates with the degree of liver fibrosis. Purpose To analyze the performance of liver MRI‐based ECV evaluations with different blood pool measurements at different time points. Study Type Prospective. Sample 73 consecutive patients (n = 31 females, mean age...
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| Veröffentlicht in: | Journal of magnetic resonance imaging 2024-10, Vol.60 (4), p.1678-1688 |
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| creator | Obmann, Verena Carola Ardoino, Marie Klaus, Jeremias Catucci, Damiano Berzigotti, Annalisa Montani, Matteo Peters, Alan Todorski, Inga Wagner, Benedikt Zbinden, Lukas Gräni, Christoph Ebner, Lukas Heverhagen, Johannes Thomas Christe, Andreas Huber, Adrian Thomas |
| description | Background
Extracellular volume (ECV) correlates with the degree of liver fibrosis.
Purpose
To analyze the performance of liver MRI‐based ECV evaluations with different blood pool measurements at different time points.
Study Type
Prospective.
Sample
73 consecutive patients (n = 31 females, mean age 56 years) with histopathology‐proven liver fibrosis.
Field Strength/Sequence
3T acquisition within 90 days of biopsy, including shortened modified look–locker inversion recovery T1 mapping.
Assessment
Polygonal regions of interest were manually drawn in the liver, aorta, vena cava, and in the main, left and right portal vein on four slices before and after Gd‐DOTA administration at 5/10/15 minutes. ECV was calculated 1) on one single slice on portal bifurcation level, and 2) averaged over all four slices.
Statistical Tests
Parameters were compared between patients with fibrosis grades F0‐2 and F3‐F4 with the Mann–Whitney U and fishers exact test. ROC analysis was used to assess the performance of the parameters to predict F3‐4 fibrosis. A P‐value |
| doi_str_mv | 10.1002/jmri.29259 |
| format | Article |
| fullrecord | <record><control><sourceid>proquest_cross</sourceid><recordid>TN_cdi_proquest_miscellaneous_3022574878</recordid><sourceformat>XML</sourceformat><sourcesystem>PC</sourcesystem><sourcerecordid>3128154889</sourcerecordid><originalsourceid>FETCH-LOGICAL-c3939-4bc3b2b0ecfae15e77b1ae48407cbd4a7633689d3a9100e1ed5e910a4f26ad513</originalsourceid><addsrcrecordid>eNp9kU1O5DAQhS0E4m9mwwGQJTYIKeCfOLGX0NAzPWo0CDFsLSepSG4lcWMnNOw4BCfkJLjphsUsWFWp9NVT1XsIHVBySglhZ7PW21OmmFAbaJcKxhImZLYZeyJ4QiXJd9BeCDNCiFKp2EY7XArBZUZ20eL6doKvnnpvSmiaoTEe37tmaAGP46i3rsO2w1P7CB6PbeFdsOHt5fUcj1w7N96GCLgaX9q6Bg9dj-9s3L1xtusDNl2FLxrnqjhwDb4GEwYPbcTCD7RVmybAz3XdR__GV3ej38n076_J6HyalFxxlaRFyQtWEChrA1RAnhfUQCpTkpdFlZo84zyTquJGRSuAQiUgdiatWWYqQfk-Ol7pzr17GCD0urVh-arpwA1Bc8KYyFOZy4ge_YfO3OC7eJ3mlEkqUilVpE5WVBm9CB5qPfe2Nf5ZU6KXcehlHPojjggfriWHooXqC_30PwJ0BSxsA8_fSOk_MaiV6Ds7xJaC</addsrcrecordid><sourcetype>Aggregation Database</sourcetype><iscdi>true</iscdi><recordtype>article</recordtype><pqid>3128154889</pqid></control><display><type>article</type><title>MRI Extracellular Volume Fraction in Liver Fibrosis—A Comparison of Different Time Points and Blood Pool Measurements</title><source>MEDLINE</source><source>Wiley Online Library Journals Frontfile Complete</source><creator>Obmann, Verena Carola ; Ardoino, Marie ; Klaus, Jeremias ; Catucci, Damiano ; Berzigotti, Annalisa ; Montani, Matteo ; Peters, Alan ; Todorski, Inga ; Wagner, Benedikt ; Zbinden, Lukas ; Gräni, Christoph ; Ebner, Lukas ; Heverhagen, Johannes Thomas ; Christe, Andreas ; Huber, Adrian Thomas</creator><creatorcontrib>Obmann, Verena Carola ; Ardoino, Marie ; Klaus, Jeremias ; Catucci, Damiano ; Berzigotti, Annalisa ; Montani, Matteo ; Peters, Alan ; Todorski, Inga ; Wagner, Benedikt ; Zbinden, Lukas ; Gräni, Christoph ; Ebner, Lukas ; Heverhagen, Johannes Thomas ; Christe, Andreas ; Huber, Adrian Thomas</creatorcontrib><description>Background
Extracellular volume (ECV) correlates with the degree of liver fibrosis.
Purpose
To analyze the performance of liver MRI‐based ECV evaluations with different blood pool measurements at different time points.
Study Type
Prospective.
Sample
73 consecutive patients (n = 31 females, mean age 56 years) with histopathology‐proven liver fibrosis.
Field Strength/Sequence
3T acquisition within 90 days of biopsy, including shortened modified look–locker inversion recovery T1 mapping.
Assessment
Polygonal regions of interest were manually drawn in the liver, aorta, vena cava, and in the main, left and right portal vein on four slices before and after Gd‐DOTA administration at 5/10/15 minutes. ECV was calculated 1) on one single slice on portal bifurcation level, and 2) averaged over all four slices.
Statistical Tests
Parameters were compared between patients with fibrosis grades F0‐2 and F3‐F4 with the Mann–Whitney U and fishers exact test. ROC analysis was used to assess the performance of the parameters to predict F3‐4 fibrosis. A P‐value <0.05 was considered statistically significant.
Results
ECV was significantly higher in F3‐4 fibrosis (35.4% [33.1%–37.6%], 36.1% [34.2%–37.5%], and 37.0% [34.8%–39.2%] at 5/10/15 minutes) than in patients with F0‐2 fibrosis (33.3% [30.8%–34.8%], 33.7% [31.6%–34.7%] and 34.9% [32.2%–36.0%]; AUC = 0.72–0.75). Blood pool T1 relaxation times in the aorta and vena cava were longer on the upper vs. lower slices at 5 minutes, but not at 10/15 minutes. AUC values were similar when measured on a single slice (AUC = 0.69–0.72) or based on blood pool measurements in the cava or portal vein (AUC = 0.63–0.67 and AUC = 0.65–0.70).
Data Conclusion
Liver ECV is significantly higher in F3‐4 fibrosis compared to F0‐2 fibrosis with blood pool measurements performed in the aorta, inferior vena cava, and portal vein at 5, 10, and 15 minutes. However, a smaller variability was observed for blood pool measurements between slices at 15 minutes.
Level of Evidence
1
Technical Efficacy
Stage 3</description><identifier>ISSN: 1053-1807</identifier><identifier>ISSN: 1522-2586</identifier><identifier>EISSN: 1522-2586</identifier><identifier>DOI: 10.1002/jmri.29259</identifier><identifier>PMID: 38553860</identifier><language>eng</language><publisher>Hoboken, USA: John Wiley & Sons, Inc</publisher><subject>Adult ; Aged ; Aorta ; Bifurcations ; Biopsy ; Blood ; Contrast Media ; Coronary vessels ; extracellular space ; Female ; Fibrosis ; Field strength ; Gadolinium ; Heterocyclic Compounds ; Histopathology ; Humans ; inflammation ; Liver ; Liver - diagnostic imaging ; Liver - pathology ; Liver cirrhosis ; Liver Cirrhosis - diagnostic imaging ; Liver Cirrhosis - pathology ; liver diseases ; Magnetic resonance imaging ; Magnetic Resonance Imaging - methods ; Male ; Middle Aged ; Organometallic Compounds ; Parameters ; Performance assessment ; Performance evaluation ; Portal vein ; Prospective Studies ; Reproducibility of Results ; ROC Curve ; Statistical analysis ; Statistical tests ; Time Factors ; Time measurement ; Veins ; Veins & arteries</subject><ispartof>Journal of magnetic resonance imaging, 2024-10, Vol.60 (4), p.1678-1688</ispartof><rights>2024 The Authors. published by Wiley Periodicals LLC on behalf of International Society for Magnetic Resonance in Medicine.</rights><rights>2024 The Authors. Journal of Magnetic Resonance Imaging published by Wiley Periodicals LLC on behalf of International Society for Magnetic Resonance in Medicine.</rights><rights>2024. This article is published under http://creativecommons.org/licenses/by-nc-nd/4.0/ (the “License”). Notwithstanding the ProQuest Terms and Conditions, you may use this content in accordance with the terms of the License.</rights><lds50>peer_reviewed</lds50><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c3939-4bc3b2b0ecfae15e77b1ae48407cbd4a7633689d3a9100e1ed5e910a4f26ad513</citedby><cites>FETCH-LOGICAL-c3939-4bc3b2b0ecfae15e77b1ae48407cbd4a7633689d3a9100e1ed5e910a4f26ad513</cites><orcidid>0000-0002-9864-6381 ; 0000-0001-6146-8238 ; 0000-0001-6572-9968</orcidid></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://onlinelibrary.wiley.com/doi/pdf/10.1002%2Fjmri.29259$$EPDF$$P50$$Gwiley$$Hfree_for_read</linktopdf><linktohtml>$$Uhttps://onlinelibrary.wiley.com/doi/full/10.1002%2Fjmri.29259$$EHTML$$P50$$Gwiley$$Hfree_for_read</linktohtml><link.rule.ids>314,776,780,1411,27901,27902,45550,45551</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/38553860$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Obmann, Verena Carola</creatorcontrib><creatorcontrib>Ardoino, Marie</creatorcontrib><creatorcontrib>Klaus, Jeremias</creatorcontrib><creatorcontrib>Catucci, Damiano</creatorcontrib><creatorcontrib>Berzigotti, Annalisa</creatorcontrib><creatorcontrib>Montani, Matteo</creatorcontrib><creatorcontrib>Peters, Alan</creatorcontrib><creatorcontrib>Todorski, Inga</creatorcontrib><creatorcontrib>Wagner, Benedikt</creatorcontrib><creatorcontrib>Zbinden, Lukas</creatorcontrib><creatorcontrib>Gräni, Christoph</creatorcontrib><creatorcontrib>Ebner, Lukas</creatorcontrib><creatorcontrib>Heverhagen, Johannes Thomas</creatorcontrib><creatorcontrib>Christe, Andreas</creatorcontrib><creatorcontrib>Huber, Adrian Thomas</creatorcontrib><title>MRI Extracellular Volume Fraction in Liver Fibrosis—A Comparison of Different Time Points and Blood Pool Measurements</title><title>Journal of magnetic resonance imaging</title><addtitle>J Magn Reson Imaging</addtitle><description>Background
Extracellular volume (ECV) correlates with the degree of liver fibrosis.
Purpose
To analyze the performance of liver MRI‐based ECV evaluations with different blood pool measurements at different time points.
Study Type
Prospective.
Sample
73 consecutive patients (n = 31 females, mean age 56 years) with histopathology‐proven liver fibrosis.
Field Strength/Sequence
3T acquisition within 90 days of biopsy, including shortened modified look–locker inversion recovery T1 mapping.
Assessment
Polygonal regions of interest were manually drawn in the liver, aorta, vena cava, and in the main, left and right portal vein on four slices before and after Gd‐DOTA administration at 5/10/15 minutes. ECV was calculated 1) on one single slice on portal bifurcation level, and 2) averaged over all four slices.
Statistical Tests
Parameters were compared between patients with fibrosis grades F0‐2 and F3‐F4 with the Mann–Whitney U and fishers exact test. ROC analysis was used to assess the performance of the parameters to predict F3‐4 fibrosis. A P‐value <0.05 was considered statistically significant.
Results
ECV was significantly higher in F3‐4 fibrosis (35.4% [33.1%–37.6%], 36.1% [34.2%–37.5%], and 37.0% [34.8%–39.2%] at 5/10/15 minutes) than in patients with F0‐2 fibrosis (33.3% [30.8%–34.8%], 33.7% [31.6%–34.7%] and 34.9% [32.2%–36.0%]; AUC = 0.72–0.75). Blood pool T1 relaxation times in the aorta and vena cava were longer on the upper vs. lower slices at 5 minutes, but not at 10/15 minutes. AUC values were similar when measured on a single slice (AUC = 0.69–0.72) or based on blood pool measurements in the cava or portal vein (AUC = 0.63–0.67 and AUC = 0.65–0.70).
Data Conclusion
Liver ECV is significantly higher in F3‐4 fibrosis compared to F0‐2 fibrosis with blood pool measurements performed in the aorta, inferior vena cava, and portal vein at 5, 10, and 15 minutes. However, a smaller variability was observed for blood pool measurements between slices at 15 minutes.
Level of Evidence
1
Technical Efficacy
Stage 3</description><subject>Adult</subject><subject>Aged</subject><subject>Aorta</subject><subject>Bifurcations</subject><subject>Biopsy</subject><subject>Blood</subject><subject>Contrast Media</subject><subject>Coronary vessels</subject><subject>extracellular space</subject><subject>Female</subject><subject>Fibrosis</subject><subject>Field strength</subject><subject>Gadolinium</subject><subject>Heterocyclic Compounds</subject><subject>Histopathology</subject><subject>Humans</subject><subject>inflammation</subject><subject>Liver</subject><subject>Liver - diagnostic imaging</subject><subject>Liver - pathology</subject><subject>Liver cirrhosis</subject><subject>Liver Cirrhosis - diagnostic imaging</subject><subject>Liver Cirrhosis - pathology</subject><subject>liver diseases</subject><subject>Magnetic resonance imaging</subject><subject>Magnetic Resonance Imaging - methods</subject><subject>Male</subject><subject>Middle Aged</subject><subject>Organometallic Compounds</subject><subject>Parameters</subject><subject>Performance assessment</subject><subject>Performance evaluation</subject><subject>Portal vein</subject><subject>Prospective Studies</subject><subject>Reproducibility of Results</subject><subject>ROC Curve</subject><subject>Statistical analysis</subject><subject>Statistical tests</subject><subject>Time Factors</subject><subject>Time measurement</subject><subject>Veins</subject><subject>Veins & arteries</subject><issn>1053-1807</issn><issn>1522-2586</issn><issn>1522-2586</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2024</creationdate><recordtype>article</recordtype><sourceid>24P</sourceid><sourceid>EIF</sourceid><recordid>eNp9kU1O5DAQhS0E4m9mwwGQJTYIKeCfOLGX0NAzPWo0CDFsLSepSG4lcWMnNOw4BCfkJLjphsUsWFWp9NVT1XsIHVBySglhZ7PW21OmmFAbaJcKxhImZLYZeyJ4QiXJd9BeCDNCiFKp2EY7XArBZUZ20eL6doKvnnpvSmiaoTEe37tmaAGP46i3rsO2w1P7CB6PbeFdsOHt5fUcj1w7N96GCLgaX9q6Bg9dj-9s3L1xtusDNl2FLxrnqjhwDb4GEwYPbcTCD7RVmybAz3XdR__GV3ej38n076_J6HyalFxxlaRFyQtWEChrA1RAnhfUQCpTkpdFlZo84zyTquJGRSuAQiUgdiatWWYqQfk-Ol7pzr17GCD0urVh-arpwA1Bc8KYyFOZy4ge_YfO3OC7eJ3mlEkqUilVpE5WVBm9CB5qPfe2Nf5ZU6KXcehlHPojjggfriWHooXqC_30PwJ0BSxsA8_fSOk_MaiV6Ds7xJaC</recordid><startdate>202410</startdate><enddate>202410</enddate><creator>Obmann, Verena Carola</creator><creator>Ardoino, Marie</creator><creator>Klaus, Jeremias</creator><creator>Catucci, Damiano</creator><creator>Berzigotti, Annalisa</creator><creator>Montani, Matteo</creator><creator>Peters, Alan</creator><creator>Todorski, Inga</creator><creator>Wagner, Benedikt</creator><creator>Zbinden, Lukas</creator><creator>Gräni, Christoph</creator><creator>Ebner, Lukas</creator><creator>Heverhagen, Johannes Thomas</creator><creator>Christe, Andreas</creator><creator>Huber, Adrian Thomas</creator><general>John Wiley & Sons, Inc</general><general>Wiley Subscription Services, Inc</general><scope>24P</scope><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7QO</scope><scope>7TK</scope><scope>8FD</scope><scope>FR3</scope><scope>K9.</scope><scope>P64</scope><scope>7X8</scope><orcidid>https://orcid.org/0000-0002-9864-6381</orcidid><orcidid>https://orcid.org/0000-0001-6146-8238</orcidid><orcidid>https://orcid.org/0000-0001-6572-9968</orcidid></search><sort><creationdate>202410</creationdate><title>MRI Extracellular Volume Fraction in Liver Fibrosis—A Comparison of Different Time Points and Blood Pool Measurements</title><author>Obmann, Verena Carola ; Ardoino, Marie ; Klaus, Jeremias ; Catucci, Damiano ; Berzigotti, Annalisa ; Montani, Matteo ; Peters, Alan ; Todorski, Inga ; Wagner, Benedikt ; Zbinden, Lukas ; Gräni, Christoph ; Ebner, Lukas ; Heverhagen, Johannes Thomas ; Christe, Andreas ; Huber, Adrian Thomas</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c3939-4bc3b2b0ecfae15e77b1ae48407cbd4a7633689d3a9100e1ed5e910a4f26ad513</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2024</creationdate><topic>Adult</topic><topic>Aged</topic><topic>Aorta</topic><topic>Bifurcations</topic><topic>Biopsy</topic><topic>Blood</topic><topic>Contrast Media</topic><topic>Coronary vessels</topic><topic>extracellular space</topic><topic>Female</topic><topic>Fibrosis</topic><topic>Field strength</topic><topic>Gadolinium</topic><topic>Heterocyclic Compounds</topic><topic>Histopathology</topic><topic>Humans</topic><topic>inflammation</topic><topic>Liver</topic><topic>Liver - diagnostic imaging</topic><topic>Liver - pathology</topic><topic>Liver cirrhosis</topic><topic>Liver Cirrhosis - diagnostic imaging</topic><topic>Liver Cirrhosis - pathology</topic><topic>liver diseases</topic><topic>Magnetic resonance imaging</topic><topic>Magnetic Resonance Imaging - methods</topic><topic>Male</topic><topic>Middle Aged</topic><topic>Organometallic Compounds</topic><topic>Parameters</topic><topic>Performance assessment</topic><topic>Performance evaluation</topic><topic>Portal vein</topic><topic>Prospective Studies</topic><topic>Reproducibility of Results</topic><topic>ROC Curve</topic><topic>Statistical analysis</topic><topic>Statistical tests</topic><topic>Time Factors</topic><topic>Time measurement</topic><topic>Veins</topic><topic>Veins & arteries</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Obmann, Verena Carola</creatorcontrib><creatorcontrib>Ardoino, Marie</creatorcontrib><creatorcontrib>Klaus, Jeremias</creatorcontrib><creatorcontrib>Catucci, Damiano</creatorcontrib><creatorcontrib>Berzigotti, Annalisa</creatorcontrib><creatorcontrib>Montani, Matteo</creatorcontrib><creatorcontrib>Peters, Alan</creatorcontrib><creatorcontrib>Todorski, Inga</creatorcontrib><creatorcontrib>Wagner, Benedikt</creatorcontrib><creatorcontrib>Zbinden, Lukas</creatorcontrib><creatorcontrib>Gräni, Christoph</creatorcontrib><creatorcontrib>Ebner, Lukas</creatorcontrib><creatorcontrib>Heverhagen, Johannes Thomas</creatorcontrib><creatorcontrib>Christe, Andreas</creatorcontrib><creatorcontrib>Huber, Adrian Thomas</creatorcontrib><collection>Wiley Online Library Open Access</collection><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>Biotechnology Research Abstracts</collection><collection>Neurosciences Abstracts</collection><collection>Technology Research Database</collection><collection>Engineering Research Database</collection><collection>ProQuest Health & Medical Complete (Alumni)</collection><collection>Biotechnology and BioEngineering Abstracts</collection><collection>MEDLINE - Academic</collection><jtitle>Journal of magnetic resonance imaging</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Obmann, Verena Carola</au><au>Ardoino, Marie</au><au>Klaus, Jeremias</au><au>Catucci, Damiano</au><au>Berzigotti, Annalisa</au><au>Montani, Matteo</au><au>Peters, Alan</au><au>Todorski, Inga</au><au>Wagner, Benedikt</au><au>Zbinden, Lukas</au><au>Gräni, Christoph</au><au>Ebner, Lukas</au><au>Heverhagen, Johannes Thomas</au><au>Christe, Andreas</au><au>Huber, Adrian Thomas</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>MRI Extracellular Volume Fraction in Liver Fibrosis—A Comparison of Different Time Points and Blood Pool Measurements</atitle><jtitle>Journal of magnetic resonance imaging</jtitle><addtitle>J Magn Reson Imaging</addtitle><date>2024-10</date><risdate>2024</risdate><volume>60</volume><issue>4</issue><spage>1678</spage><epage>1688</epage><pages>1678-1688</pages><issn>1053-1807</issn><issn>1522-2586</issn><eissn>1522-2586</eissn><abstract>Background
Extracellular volume (ECV) correlates with the degree of liver fibrosis.
Purpose
To analyze the performance of liver MRI‐based ECV evaluations with different blood pool measurements at different time points.
Study Type
Prospective.
Sample
73 consecutive patients (n = 31 females, mean age 56 years) with histopathology‐proven liver fibrosis.
Field Strength/Sequence
3T acquisition within 90 days of biopsy, including shortened modified look–locker inversion recovery T1 mapping.
Assessment
Polygonal regions of interest were manually drawn in the liver, aorta, vena cava, and in the main, left and right portal vein on four slices before and after Gd‐DOTA administration at 5/10/15 minutes. ECV was calculated 1) on one single slice on portal bifurcation level, and 2) averaged over all four slices.
Statistical Tests
Parameters were compared between patients with fibrosis grades F0‐2 and F3‐F4 with the Mann–Whitney U and fishers exact test. ROC analysis was used to assess the performance of the parameters to predict F3‐4 fibrosis. A P‐value <0.05 was considered statistically significant.
Results
ECV was significantly higher in F3‐4 fibrosis (35.4% [33.1%–37.6%], 36.1% [34.2%–37.5%], and 37.0% [34.8%–39.2%] at 5/10/15 minutes) than in patients with F0‐2 fibrosis (33.3% [30.8%–34.8%], 33.7% [31.6%–34.7%] and 34.9% [32.2%–36.0%]; AUC = 0.72–0.75). Blood pool T1 relaxation times in the aorta and vena cava were longer on the upper vs. lower slices at 5 minutes, but not at 10/15 minutes. AUC values were similar when measured on a single slice (AUC = 0.69–0.72) or based on blood pool measurements in the cava or portal vein (AUC = 0.63–0.67 and AUC = 0.65–0.70).
Data Conclusion
Liver ECV is significantly higher in F3‐4 fibrosis compared to F0‐2 fibrosis with blood pool measurements performed in the aorta, inferior vena cava, and portal vein at 5, 10, and 15 minutes. However, a smaller variability was observed for blood pool measurements between slices at 15 minutes.
Level of Evidence
1
Technical Efficacy
Stage 3</abstract><cop>Hoboken, USA</cop><pub>John Wiley & Sons, Inc</pub><pmid>38553860</pmid><doi>10.1002/jmri.29259</doi><tpages>11</tpages><orcidid>https://orcid.org/0000-0002-9864-6381</orcidid><orcidid>https://orcid.org/0000-0001-6146-8238</orcidid><orcidid>https://orcid.org/0000-0001-6572-9968</orcidid><oa>free_for_read</oa></addata></record> |
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| ispartof | Journal of magnetic resonance imaging, 2024-10, Vol.60 (4), p.1678-1688 |
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| subjects | Adult Aged Aorta Bifurcations Biopsy Blood Contrast Media Coronary vessels extracellular space Female Fibrosis Field strength Gadolinium Heterocyclic Compounds Histopathology Humans inflammation Liver Liver - diagnostic imaging Liver - pathology Liver cirrhosis Liver Cirrhosis - diagnostic imaging Liver Cirrhosis - pathology liver diseases Magnetic resonance imaging Magnetic Resonance Imaging - methods Male Middle Aged Organometallic Compounds Parameters Performance assessment Performance evaluation Portal vein Prospective Studies Reproducibility of Results ROC Curve Statistical analysis Statistical tests Time Factors Time measurement Veins Veins & arteries |
| title | MRI Extracellular Volume Fraction in Liver Fibrosis—A Comparison of Different Time Points and Blood Pool Measurements |
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