Enzyme Core Spherical Nucleic Acid That Enables Enhanced Cuproptosis and Antitumor Immune Response through Alleviating Tumor Hypoxia

Cuproptosis, a copper-dependent cell death process, has been confirmed to further activate the immune response and mediate the immune resistance. However, hypoxic tumor microenvironment hampers cuproptosis sensitivity and suppresses the body’s antitumor immune response. Herein, we have successfully...

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Veröffentlicht in:Journal of the American Chemical Society 2024-05, Vol.146 (20), p.13805-13816
Hauptverfasser: Huang, Yuting, Liu, Xueliang, Zhu, Jiawei, Chen, Zhejie, Yu, Lu, Huang, Xin, Dong, Chuhuang, Li, Jiabei, Zhou, Huayuan, Yang, Yu, Tan, Weihong
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Sprache:eng
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