The thrombopoietin mimetic JNJ-26366821 reduces the late injury and accelerates the onset of liver recovery after acetaminophen-induced liver injury in mice

Acetaminophen (APAP)-induced hepatotoxicity is comprised of an injury and recovery phase. While pharmacological interventions, such as N -acetylcysteine (NAC) and 4-methylpyrazole (4-MP), prevent injury there are no therapeutics that promote recovery. JNJ-26366821 (TPOm) is a novel thrombopoietin mi...

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Veröffentlicht in:	Archives of toxicology 2024-06, Vol.98 (6), p.1843-1858
Hauptverfasser:	Adelusi, Olamide B., Akakpo, Jephte Y., Eichenbaum, Gary, Sadaff, Ejaz, Ramachandran, Anup, Jaeschke, Hartmut
Format:	Artikel
Sprache:	eng
Schlagworte:	Acetaminophen Acetaminophen - toxicity Acetylcysteine Acetylcysteine - pharmacology Adducts Analgesics Animals Biomedical and Life Sciences Biomedicine Cell Proliferation - drug effects Chemical and Drug Induced Liver Injury - drug therapy Chemical and Drug Induced Liver Injury - prevention & control DNA adducts DNA fragmentation Endothelial cells Environmental Health Hepatocytes Hepatocytes - drug effects Hepatotoxicity Homology Injury prevention Liver Liver - drug effects Liver - metabolism Liver - pathology Liver Regeneration - drug effects Male males Megakaryocytes Mice Mice, Inbred C57BL Necrosis Occupational Medicine/Industrial Medicine Organ Toxicity and Mechanisms Overdose Oxidants Oxidative Stress - drug effects Oxidizing agents Parameters Pharmacology/Toxicology Protein adducts Pyrazoles - pharmacology Receptors Receptors, Thrombopoietin - metabolism Recovery sequence homology Thrombopoietin Thrombopoietin - pharmacology
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