Pyrimidines maintain mitochondrial pyruvate oxidation to support de novo lipogenesis

Cellular purines, particularly adenosine 5'-triphosphate (ATP), fuel many metabolic reactions, but less is known about the direct effects of pyrimidines on cellular metabolism. We found that pyrimidines, but not purines, maintain pyruvate oxidation and the tricarboxylic citric acid (TCA) cycle...

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Veröffentlicht in:	Science (American Association for the Advancement of Science) 2024-03, Vol.383 (6690), p.1484-1492
Hauptverfasser:	Sahu, Umakant, Villa, Elodie, Reczek, Colleen R, Zhao, Zibo, O'Hara, Brendan P, Torno, Michael D, Mishra, Rohan, Shannon, William D, Asara, John M, Gao, Peng, Shilatifard, Ali, Chandel, Navdeep S, Ben-Sahra, Issam
Format:	Artikel
Sprache:	eng
Schlagworte:	Adenosine Triphosphate - metabolism Biosynthesis Citric Acid Cycle Dehydrogenase Glycolysis HeLa Cells Humans Lipogenesis Metabolites Oxidation Oxidation-Reduction Protein Kinases - metabolism Pyrimidines Pyrimidines - metabolism Pyruvate Dehydrogenase Complex - metabolism Pyruvates - metabolism Pyruvic acid Respiration Substrates Thiamine Thiamine - metabolism Thiamine Pyrophosphate - metabolism Tricarboxylic acid cycle Uridine Triphosphate - metabolism
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