Magnesium alleviates extracellular histone-induced apoptosis and defective bacterial phagocytosis in macrophages by regulating intracellular calcium signal

•Circulating histones negatively correlate with monocyte levels in septic patients.•Histones induce apoptosis and defective bacterial phagocytosis in macrophages.•Low Mg2+ levels are linked to low monocyte levels in septic patients.•Mg2+ attenuates histone-induced macrophage damage by regulating the...

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Veröffentlicht in:	International immunopharmacology 2024-05, Vol.132, p.111870-111870, Article 111870
Hauptverfasser:	Zhong, Tao, Chen, Sainan, Deng, Ke, Guan, Jianbin, Zhang, Jiaqi, Lu, Furong, Shichen, Maoyou, Lv, Ronggui, Liu, Zhifeng, Liu, Yong, Chang, Ping, Liu, Zhanguo
Format:	Artikel
Sprache:	eng
Schlagworte:	Animals Apoptosis Apoptosis - drug effects Calcium Signaling - drug effects Extracellular histone Female Histones - metabolism Humans Macrophage Macrophages - drug effects Macrophages - immunology Macrophages - metabolism Magnesium Magnesium - metabolism Male Mice Mice, Inbred C57BL Middle Aged Phagocytosis Phagocytosis - drug effects RAW 264.7 Cells Sepsis Sepsis - drug therapy Sepsis - immunology Sepsis - metabolism
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