Prevalence and Consequences of a Delayed Diagnosis in Multiple Myeloma: A Single Institution Experience
Multiple myeloma (MM) is a disease with unspecific initial symptoms which may lead into a delay in the diagnosis, seemingly increasing the risk of complications and in turn reducing the overall survival (OS). To analyze the consequences of a delayed diagnosis of MM in both the OS and the progression...
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| Veröffentlicht in: | Clinical lymphoma, myeloma and leukemia myeloma and leukemia, 2024-07, Vol.24 (7), p.478-483 |
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| creator | Negrete-Rodríguez, Paola Gallardo-Pérez, Moisés Manuel Lira-Lara, Olivia Melgar-de-la-Paz, Miranda Hamilton-Avilés, Luis Enrique Ocaña-Ramm, Guillermo Robles-Nasta, Max Sánchez-Bonilla, Daniela Olivares-Gazca, Juan Carlos Mateos, María-Victoria Ruiz-Delgado, Guillermo J. Ruiz-Argüelles, Guillermo J. |
| description | Multiple myeloma (MM) is a disease with unspecific initial symptoms which may lead into a delay in the diagnosis, seemingly increasing the risk of complications and in turn reducing the overall survival (OS).
To analyze the consequences of a delayed diagnosis of MM in both the OS and the progression-free survival (PFS) of the patients in a single center in México.
The study included patients with MM who were diagnosed at Clínica Ruiz, Puebla, México, between 1983 and 2022. According to the time elapsed between the onset of symptoms to the establishment of the definite diagnosis of MM, 4 groups were constructed: 1) Less than 3 months, 2) 3-6 months, 3) 6-12 months, and 4) More than 12 months.
About 136 patients had a complete clinical record and at least a 3-month follow up period. A delay in the diagnosis of MM (more than 3 months from the onset of symptoms) was recorded in 92/136 persons (68%). The median follow-up for the whole group was 24.7 months, median OS was 131.4 months, whereas median PFS was 85.4 months. There was a significant trend for being in earlier stages of the disease and being diagnosed within 3 months from the onset of symptoms (P = .049). Both OS and PFS were similar in the patients diagnosed before or after 3 months from the symptoms onset (P = .772). The 6-12 months group was the group with the better median both OS (197.4 months) and DFS (197.4) from the diagnosis. The median OS for the other groups were similar among them.
A delay in the diagnosis of MM is very frequent in México (68% of cases); despite the fact that there was a significant trend for being in earlier stages of the disease and being diagnosed within 3 months from the onset of symptoms, we did not find a relationship between a delay on the diagnosis of the disease and a higher risk of complications and/or poor prognosis. Possible explanations to these findings are discussed.
A delay in the diagnosis of Multiple Myeloma is very frequent in México; in this study we did not find a relationship between a delay on the diagnosis of the disease and a higher risk of complications and/or poor prognosis. |
| doi_str_mv | 10.1016/j.clml.2024.03.004 |
| format | Article |
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To analyze the consequences of a delayed diagnosis of MM in both the OS and the progression-free survival (PFS) of the patients in a single center in México.
The study included patients with MM who were diagnosed at Clínica Ruiz, Puebla, México, between 1983 and 2022. According to the time elapsed between the onset of symptoms to the establishment of the definite diagnosis of MM, 4 groups were constructed: 1) Less than 3 months, 2) 3-6 months, 3) 6-12 months, and 4) More than 12 months.
About 136 patients had a complete clinical record and at least a 3-month follow up period. A delay in the diagnosis of MM (more than 3 months from the onset of symptoms) was recorded in 92/136 persons (68%). The median follow-up for the whole group was 24.7 months, median OS was 131.4 months, whereas median PFS was 85.4 months. There was a significant trend for being in earlier stages of the disease and being diagnosed within 3 months from the onset of symptoms (P = .049). Both OS and PFS were similar in the patients diagnosed before or after 3 months from the symptoms onset (P = .772). The 6-12 months group was the group with the better median both OS (197.4 months) and DFS (197.4) from the diagnosis. The median OS for the other groups were similar among them.
A delay in the diagnosis of MM is very frequent in México (68% of cases); despite the fact that there was a significant trend for being in earlier stages of the disease and being diagnosed within 3 months from the onset of symptoms, we did not find a relationship between a delay on the diagnosis of the disease and a higher risk of complications and/or poor prognosis. Possible explanations to these findings are discussed.
A delay in the diagnosis of Multiple Myeloma is very frequent in México; in this study we did not find a relationship between a delay on the diagnosis of the disease and a higher risk of complications and/or poor prognosis.</description><identifier>ISSN: 2152-2650</identifier><identifier>ISSN: 2152-2669</identifier><identifier>EISSN: 2152-2669</identifier><identifier>DOI: 10.1016/j.clml.2024.03.004</identifier><identifier>PMID: 38555259</identifier><language>eng</language><publisher>United States: Elsevier Inc</publisher><subject>Adult ; Aged ; Aged, 80 and over ; Delayed Diagnosis ; Female ; Humans ; Male ; Mexico - epidemiology ; Middle Aged ; Multiple Myeloma - diagnosis ; Multiple Myeloma - epidemiology ; Multiple Myeloma - mortality ; Overall survival ; Prevalence ; Prognosis ; Progression free survival ; Time to diagnosis</subject><ispartof>Clinical lymphoma, myeloma and leukemia, 2024-07, Vol.24 (7), p.478-483</ispartof><rights>2024 Elsevier Inc.</rights><rights>Copyright © 2024 Elsevier Inc. All rights reserved.</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><cites>FETCH-LOGICAL-c307t-5ab574b19c167c19ce66116b0f391a64aad9fb12e733d843c090854db4df8ece3</cites><orcidid>0000-0002-9335-0653</orcidid></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktohtml>$$Uhttps://dx.doi.org/10.1016/j.clml.2024.03.004$$EHTML$$P50$$Gelsevier$$H</linktohtml><link.rule.ids>314,780,784,3550,27924,27925,45995</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/38555259$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Negrete-Rodríguez, Paola</creatorcontrib><creatorcontrib>Gallardo-Pérez, Moisés Manuel</creatorcontrib><creatorcontrib>Lira-Lara, Olivia</creatorcontrib><creatorcontrib>Melgar-de-la-Paz, Miranda</creatorcontrib><creatorcontrib>Hamilton-Avilés, Luis Enrique</creatorcontrib><creatorcontrib>Ocaña-Ramm, Guillermo</creatorcontrib><creatorcontrib>Robles-Nasta, Max</creatorcontrib><creatorcontrib>Sánchez-Bonilla, Daniela</creatorcontrib><creatorcontrib>Olivares-Gazca, Juan Carlos</creatorcontrib><creatorcontrib>Mateos, María-Victoria</creatorcontrib><creatorcontrib>Ruiz-Delgado, Guillermo J.</creatorcontrib><creatorcontrib>Ruiz-Argüelles, Guillermo J.</creatorcontrib><title>Prevalence and Consequences of a Delayed Diagnosis in Multiple Myeloma: A Single Institution Experience</title><title>Clinical lymphoma, myeloma and leukemia</title><addtitle>Clin Lymphoma Myeloma Leuk</addtitle><description>Multiple myeloma (MM) is a disease with unspecific initial symptoms which may lead into a delay in the diagnosis, seemingly increasing the risk of complications and in turn reducing the overall survival (OS).
To analyze the consequences of a delayed diagnosis of MM in both the OS and the progression-free survival (PFS) of the patients in a single center in México.
The study included patients with MM who were diagnosed at Clínica Ruiz, Puebla, México, between 1983 and 2022. According to the time elapsed between the onset of symptoms to the establishment of the definite diagnosis of MM, 4 groups were constructed: 1) Less than 3 months, 2) 3-6 months, 3) 6-12 months, and 4) More than 12 months.
About 136 patients had a complete clinical record and at least a 3-month follow up period. A delay in the diagnosis of MM (more than 3 months from the onset of symptoms) was recorded in 92/136 persons (68%). The median follow-up for the whole group was 24.7 months, median OS was 131.4 months, whereas median PFS was 85.4 months. There was a significant trend for being in earlier stages of the disease and being diagnosed within 3 months from the onset of symptoms (P = .049). Both OS and PFS were similar in the patients diagnosed before or after 3 months from the symptoms onset (P = .772). The 6-12 months group was the group with the better median both OS (197.4 months) and DFS (197.4) from the diagnosis. The median OS for the other groups were similar among them.
A delay in the diagnosis of MM is very frequent in México (68% of cases); despite the fact that there was a significant trend for being in earlier stages of the disease and being diagnosed within 3 months from the onset of symptoms, we did not find a relationship between a delay on the diagnosis of the disease and a higher risk of complications and/or poor prognosis. Possible explanations to these findings are discussed.
A delay in the diagnosis of Multiple Myeloma is very frequent in México; in this study we did not find a relationship between a delay on the diagnosis of the disease and a higher risk of complications and/or poor prognosis.</description><subject>Adult</subject><subject>Aged</subject><subject>Aged, 80 and over</subject><subject>Delayed Diagnosis</subject><subject>Female</subject><subject>Humans</subject><subject>Male</subject><subject>Mexico - epidemiology</subject><subject>Middle Aged</subject><subject>Multiple Myeloma - diagnosis</subject><subject>Multiple Myeloma - epidemiology</subject><subject>Multiple Myeloma - mortality</subject><subject>Overall survival</subject><subject>Prevalence</subject><subject>Prognosis</subject><subject>Progression free survival</subject><subject>Time to diagnosis</subject><issn>2152-2650</issn><issn>2152-2669</issn><issn>2152-2669</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2024</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNp9kEtr3DAUhUVoyWPaP5BF0LKbca8kyx6XbMLk0UBCC23XQpauBw2yNJHskPn3sTtpll3dB-ccOB8h5wwKBqz6ui2M733BgZcFiAKgPCKnnEm-5FXVfHjfJZyQs5y3ADUAa47JiVhJKblsTsnmZ8Jn7TEYpDpYuo4h49M435nGjmp6jV7v0dJrpzchZpepC_Rx9IPbeaSPe_Sx19_oFf3lwmb63Ic8uGEcXAz05mWHyc1hn8jHTvuMn9_mgvy5vfm9_r58-HF3v756WBoB9bCUupV12bLGsKo208CqYqxqoRMN01WptW26lnGshbCrUhhoYCVL25a2W6FBsSBfDrm7FKcaeVC9ywa91wHjmJUAzmXNYPIuCD9ITYo5J-zULrlep71ioGbAaqtmwGoGrECoCfBkunjLH9se7bvlH9FJcHkQ4NTy2WFS2fwlYF1CMygb3f_yXwEBN4y5</recordid><startdate>20240701</startdate><enddate>20240701</enddate><creator>Negrete-Rodríguez, Paola</creator><creator>Gallardo-Pérez, Moisés Manuel</creator><creator>Lira-Lara, Olivia</creator><creator>Melgar-de-la-Paz, Miranda</creator><creator>Hamilton-Avilés, Luis Enrique</creator><creator>Ocaña-Ramm, Guillermo</creator><creator>Robles-Nasta, Max</creator><creator>Sánchez-Bonilla, Daniela</creator><creator>Olivares-Gazca, Juan Carlos</creator><creator>Mateos, María-Victoria</creator><creator>Ruiz-Delgado, Guillermo J.</creator><creator>Ruiz-Argüelles, Guillermo J.</creator><general>Elsevier Inc</general><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7X8</scope><orcidid>https://orcid.org/0000-0002-9335-0653</orcidid></search><sort><creationdate>20240701</creationdate><title>Prevalence and Consequences of a Delayed Diagnosis in Multiple Myeloma: A Single Institution Experience</title><author>Negrete-Rodríguez, Paola ; 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To analyze the consequences of a delayed diagnosis of MM in both the OS and the progression-free survival (PFS) of the patients in a single center in México.
The study included patients with MM who were diagnosed at Clínica Ruiz, Puebla, México, between 1983 and 2022. According to the time elapsed between the onset of symptoms to the establishment of the definite diagnosis of MM, 4 groups were constructed: 1) Less than 3 months, 2) 3-6 months, 3) 6-12 months, and 4) More than 12 months.
About 136 patients had a complete clinical record and at least a 3-month follow up period. A delay in the diagnosis of MM (more than 3 months from the onset of symptoms) was recorded in 92/136 persons (68%). The median follow-up for the whole group was 24.7 months, median OS was 131.4 months, whereas median PFS was 85.4 months. There was a significant trend for being in earlier stages of the disease and being diagnosed within 3 months from the onset of symptoms (P = .049). Both OS and PFS were similar in the patients diagnosed before or after 3 months from the symptoms onset (P = .772). The 6-12 months group was the group with the better median both OS (197.4 months) and DFS (197.4) from the diagnosis. The median OS for the other groups were similar among them.
A delay in the diagnosis of MM is very frequent in México (68% of cases); despite the fact that there was a significant trend for being in earlier stages of the disease and being diagnosed within 3 months from the onset of symptoms, we did not find a relationship between a delay on the diagnosis of the disease and a higher risk of complications and/or poor prognosis. Possible explanations to these findings are discussed.
A delay in the diagnosis of Multiple Myeloma is very frequent in México; in this study we did not find a relationship between a delay on the diagnosis of the disease and a higher risk of complications and/or poor prognosis.</abstract><cop>United States</cop><pub>Elsevier Inc</pub><pmid>38555259</pmid><doi>10.1016/j.clml.2024.03.004</doi><tpages>6</tpages><orcidid>https://orcid.org/0000-0002-9335-0653</orcidid></addata></record> |
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| subjects | Adult Aged Aged, 80 and over Delayed Diagnosis Female Humans Male Mexico - epidemiology Middle Aged Multiple Myeloma - diagnosis Multiple Myeloma - epidemiology Multiple Myeloma - mortality Overall survival Prevalence Prognosis Progression free survival Time to diagnosis |
| title | Prevalence and Consequences of a Delayed Diagnosis in Multiple Myeloma: A Single Institution Experience |
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