Deconstructing pathological tau by biological process in early stages of Alzheimer disease: a method for quantifying tau spatial spread in neuroimaging

Neuroimaging studies often quantify tau burden in standardized brain regions to assess Alzheimer disease (AD) progression. However, this method ignores another key biological process in which tau spreads to additional brain regions. We have developed a metric for calculating the extent tau pathology...

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Veröffentlicht in:	EBioMedicine 2024-05, Vol.103, p.105080, Article 105080
Hauptverfasser:	Doering, Stephanie, McCullough, Austin, Chen, Charles D., McKay, Nicole, Hobbs, Diana, Keefe, Sarah, Flores, Shaney, Jarman, Stephen, Jackson, Kelley, Hornbeck, Russ C., Ances, Beau M., Hassenstab, Jason, Cruchaga, Carlos, Bateman, Randall J., Noble, James M., Day, Gregory S., Graff-Radford, Neill R., Voglein, Jonathan, Allegri, Ricardo F., Mendez, Patricio Chrem, Berman, Sarah B., Ikonomovic, Snezana, Nadkarni, Neelesh K., Lopera, Francisco, Ramirez, Laura, Baena, Ana, Londono, Natalia, Moreno, Sonia, Jucker, Mathias, Laske, Christoph, Kuder-Buletta, Elke, Graber-Sultan, Susanne, Preische, Oliver, Hofmann, Anna, Ikeuchi, Takeshi, Kasuga, Kensaku, Niimi, Yoshiki, Ishii, Kenji, Senda, Michio, Sanchez-Valle, Raquel, Rosa-Neto, Pedro, Fox, Nick C., Cash, Dave, Roh, Jee Hoon, Salloway, Stephen, Riddle, Meghan C., Menard, William, Takada, Leonel Tadao, Farlow, Martin, Chhatwal, Jasmeer P., Sanchez-Gonzalez, V.J., Orozco-Barajas, Maribel, Goate, Alison M., Renton, Alan E., Esposito, Bianca T., Karch, Celeste M., Marsh, Jacob, Fernanadez, Victoria, Fagan, Anne M., Herries, Elizabeth, Llibre-Guerra, Jorge, Levey, Allan I., Johnson, Erik C.B., Seyfried, Nicholas T., Schofield, Peter R., Brooks, William S., Bechara, Jacob A., Bateman, Randall, McDade, Eric, Franklin, Erin E., Chen, Allison, Chen, Charles, Friedrichsen, Nelly, Gordon, Brian, Hantler, Nancy, Hornbeck, Russ, Jarman, Steve, Koudelis, Deborah, Massoumzadeh, Parinaz, Nicklaus, Joyce, Pulizos, Christine, Wang, Qing, Candela, Madison, Wang, Peter, Li, Yan, Gremminger, Emily, Ma, Yinjiao, Bui, Ryan, Lu, Ruijin, Martins, Ralph, Sosa Ortiz, Ana Luisa, Courtney, Laura, Supnet-Bell, Charlene, Xu, Jinbin, Ringman, John, Barthelemy, Nicolas, Morris, John, Morris, John C., Benzinger, Tammie L.S.
Format:	Artikel
Sprache:	eng
Schlagworte:	Aged Aged, 80 and over Alzheimer disease Alzheimer Disease - diagnostic imaging Alzheimer Disease - metabolism Alzheimer Disease - pathology Biomarkers Brain - diagnostic imaging Brain - metabolism Brain - pathology Cross-Sectional Studies Disease Progression Female Humans Magnetic Resonance Imaging - methods Male Middle Aged Neuroimaging - methods Positron emission tomography Positron-Emission Tomography - methods Tau propagation tau Proteins - metabolism Tau spread
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