High-throughput BCRP inhibitors screening system based on styrene maleic acid polymer membrane protein stabilization strategy and surface plasmon resonance biosensor

Multidrug resistance (MDR) is a dominant challenge in cancer chemotherapy failure. The over-expression of breast cancer resistance protein (BCRP) in tumorous cells, along with its extensive substrate profile, is a leading cause of tumor MDR. Herein, on the basis of styrene maleic acid (SMA) polymer...

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Veröffentlicht in:	Talanta (Oxford) 2024-07, Vol.274, p.125987-125987, Article 125987
Hauptverfasser:	Fang, Jiahao, Shen, Shuqi, Wang, Hui, He, Yuzhen, Chao, Liang, Cao, Yan, Chen, Xiaofei, Zhu, Zhenyu, Hong, Zhanying, Chai, Yifeng
Format:	Artikel
Sprache:	eng
Schlagworte:	Animals ATP Binding Cassette Transporter, Subfamily G, Member 2 - antagonists & inhibitors ATP Binding Cassette Transporter, Subfamily G, Member 2 - metabolism Biosensing Techniques - methods Breast cancer resistance protein High-throughput screening High-Throughput Screening Assays - methods Humans Maleates - chemistry Maleates - pharmacology Multidrug resistance Neoplasm Proteins - analysis Neoplasm Proteins - antagonists & inhibitors Neoplasm Proteins - metabolism Polystyrenes - chemistry Styrene maleic acid Surface plasmon resonance Surface Plasmon Resonance - methods Swine
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