Crystal structure of the Mycobacterium tuberculosis VirS regulator reveals its interaction with the lead compound SMARt751

[Display omitted] •Enhancing anti-tuberculosis efficacy of ETO is mediated by VirS synthetic ligands.•A crystal of the regulator VirS has been obtained using an in situ proteolysis method.•The structure of VirS in complex with the lead compound SMARt751 has been resolved.•The atomic-level details of...

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Veröffentlicht in:	Journal of structural biology 2024-06, Vol.216 (2), p.108090-108090, Article 108090
Hauptverfasser:	Grosse, Camille, Sigoillot, Maud, Megalizzi, Véronique, Tanina, Abdalkarim, Willand, Nicolas, Baulard, Alain R., Wintjens, René
Format:	Artikel
Sprache:	eng
Schlagworte:	AlphaFold model AraC regulator Bacterial Proteins - chemistry Bacterial Proteins - metabolism Binding Sites Crystallography, X-Ray Ethionamide Ethionamide - chemistry Ethionamide - metabolism Ligands Mycobacterium tuberculosis - metabolism Protein Binding Protein–ligand complex X-ray crystallography
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