New pyridine‐based chalcones and pyrazolines with anticancer, antibacterial, and antiplasmodial activities

New pyridine‐based chalcones 4a–h and pyrazolines 5a–h (N‐acetyl), 6a–h (N‐phenyl), and 7a–h (N‐4‐chlorophenyl) were synthesized and evaluated by the National Cancer Institute (NCI) against 60 different human cancer cell lines. Pyrazolines 6a, 6c–h, and 7a–h satisfied the pre‐determined threshold in...

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Veröffentlicht in:	Archiv der Pharmazie (Weinheim) 2024-07, Vol.357 (7), p.e2400081-n/a
Hauptverfasser:	Ramírez‐Prada, Jonathan, Rocha‐Ortiz, Juan S., Orozco, Marta I., Moreno, Pedro, Guevara, Miguel, Barreto, Mauricio, Burbano, Maria E., Robledo, Sara, Crespo‐Ortiz, Maria del Pilar, Quiroga, Jairo, Abonia, Rodrigo, Cuartas, Viviana, Insuasty, Braulio
Format:	Artikel
Sprache:	eng
Schlagworte:	Animals Anti-Bacterial Agents - chemical synthesis Anti-Bacterial Agents - chemistry Anti-Bacterial Agents - pharmacology Antimalarials - chemical synthesis Antimalarials - chemistry Antimalarials - pharmacology Antineoplastic Agents - chemical synthesis Antineoplastic Agents - chemistry Antineoplastic Agents - pharmacology biological activity Cancer Cell Line, Tumor Cell Proliferation - drug effects chalcones Chalcones - chemical synthesis Chalcones - chemistry Chalcones - pharmacology Dose-Response Relationship, Drug Drug Screening Assays, Antitumor Humans Microbial Sensitivity Tests Molecular Docking Simulation Molecular Structure Neisseria gonorrhoeae - drug effects Plasmodium falciparum - drug effects Pyrazoles - chemical synthesis Pyrazoles - chemistry Pyrazoles - pharmacology pyrazoline pyridine Pyridines - chemical synthesis Pyridines - chemistry Pyridines - pharmacology Structure-Activity Relationship synthesis
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