Assessment of renal function in persons with motor complete spinal cord injury—cystatin C as an accurate single marker
Study design Observational cohort. Aim To show that Cystatin C is an accurate single marker to estimate GFR in motor complete persons with SCI. Objectives To assess if Cystatin C is an accurate for estimating GFR in persons with SCI with no preserved motor power. To study if use of Serum creatinine...
Gespeichert in:
| Veröffentlicht in: | Spinal cord 2024-06, Vol.62 (6), p.295-299 |
|---|---|
| Hauptverfasser: | , , , |
| Format: | Artikel |
| Sprache: | eng |
| Schlagworte: | |
| Online-Zugang: | Volltext |
| Tags: |
Tag hinzufügen
Keine Tags, Fügen Sie den ersten Tag hinzu!
|
| container_end_page | 299 |
|---|---|
| container_issue | 6 |
| container_start_page | 295 |
| container_title | Spinal cord |
| container_volume | 62 |
| creator | Augustine, Thomas Anand M, Henry Prakash Alexander, Suceena S, Mahasampath Gowri |
| description | Study design
Observational cohort.
Aim
To show that Cystatin C is an accurate single marker to estimate GFR in motor complete persons with SCI.
Objectives
To assess if Cystatin C is an accurate for estimating GFR in persons with SCI with no preserved motor power. To study if use of Serum creatinine for estimation of GFR in this population significantly overestimates GFR, thereby inaccurate.
Setting
Tertiary care hospital and Medical College, Vellore, South India.
Methods
30 persons with SCI (ASIA A and B) fulfilling the inclusion criteria were recruited. Serum Creatinine and Serum Cystatin C values were obtained, and eGFR was calculated based on available formulae. 24-h urine for urine creatinine clearance-based eGFR was used as a reference value.
Results
Analysis with a Bland-Atman plot showed that eGFR estimated with Serum Cystatin C was more accurate than Serum Creatinine, using 24-h urine creatinine as a reference value. eGFR using Serum Creatinine significantly overestimated GFR by over 50.6%. Estimated GFR using Serum Cystatin C showed a meager mean difference of 0.5% from the reference 24-h urine creatinine clearance (mean difference of –2.56%).
Conclusion
Serum Cystatin C is a much more accurate marker for estimating GFR in SCI, compared to serum Creatinine which overestimates GFR. |
| doi_str_mv | 10.1038/s41393-024-00973-y |
| format | Article |
| fullrecord | <record><control><sourceid>proquest_cross</sourceid><recordid>TN_cdi_proquest_miscellaneous_3022567764</recordid><sourceformat>XML</sourceformat><sourcesystem>PC</sourcesystem><sourcerecordid>3072089719</sourcerecordid><originalsourceid>FETCH-LOGICAL-c326t-4250fef123fd8266932a414a0d19cba3e8639e5423e6e82464437a4ea5ee75f13</originalsourceid><addsrcrecordid>eNp90ctO3DAUBmCrAhUKfQEWlSU23aT4FsdZohG9SEjdwNoynhOaIbFTH0eQXR-iT9gnwcPQVmLBypb8_cc6-gk54ewTZ9KcoeKylRUTqmKsbWS1vCGHXDW6qrVQe-UutahUMQfkHeKGFcVb85YcSFMrY7Q6JA_niIA4Qsg0djRBcAPt5uBzHwPtA50gYQxI7_v8g44xx0R9HKcBMlCc-i33Ma0L3cxp-fPrt18wu1ySK-qQukCd93NyW96H2wHo6NIdpGOy37kB4f3zeUSuP19crb5Wl9-_fFudX1ZeCp0rJWrWQceF7NZGaN1K4RRXjq1562-cBKNlC7USEjQYobRSsnEKXA3Q1B2XR-Tjbu6U4s8ZMNuxRw_D4ALEGa1kQtS6abQq9PQF3cQ5lQ23qhHMtA1vixI75VNETNDZKfVlp8VyZre92F0vtvRin3qxSwl9eB4934yw_hf5W0QBcgewPIVbSP__fmXsI2ggmvc</addsrcrecordid><sourcetype>Aggregation Database</sourcetype><iscdi>true</iscdi><recordtype>article</recordtype><pqid>3072089719</pqid></control><display><type>article</type><title>Assessment of renal function in persons with motor complete spinal cord injury—cystatin C as an accurate single marker</title><source>MEDLINE</source><source>Springer Nature - Complete Springer Journals</source><creator>Augustine, Thomas Anand ; M, Henry Prakash ; Alexander, Suceena ; S, Mahasampath Gowri</creator><creatorcontrib>Augustine, Thomas Anand ; M, Henry Prakash ; Alexander, Suceena ; S, Mahasampath Gowri</creatorcontrib><description>Study design
Observational cohort.
Aim
To show that Cystatin C is an accurate single marker to estimate GFR in motor complete persons with SCI.
Objectives
To assess if Cystatin C is an accurate for estimating GFR in persons with SCI with no preserved motor power. To study if use of Serum creatinine for estimation of GFR in this population significantly overestimates GFR, thereby inaccurate.
Setting
Tertiary care hospital and Medical College, Vellore, South India.
Methods
30 persons with SCI (ASIA A and B) fulfilling the inclusion criteria were recruited. Serum Creatinine and Serum Cystatin C values were obtained, and eGFR was calculated based on available formulae. 24-h urine for urine creatinine clearance-based eGFR was used as a reference value.
Results
Analysis with a Bland-Atman plot showed that eGFR estimated with Serum Cystatin C was more accurate than Serum Creatinine, using 24-h urine creatinine as a reference value. eGFR using Serum Creatinine significantly overestimated GFR by over 50.6%. Estimated GFR using Serum Cystatin C showed a meager mean difference of 0.5% from the reference 24-h urine creatinine clearance (mean difference of –2.56%).
Conclusion
Serum Cystatin C is a much more accurate marker for estimating GFR in SCI, compared to serum Creatinine which overestimates GFR.</description><identifier>ISSN: 1362-4393</identifier><identifier>ISSN: 1476-5624</identifier><identifier>EISSN: 1476-5624</identifier><identifier>DOI: 10.1038/s41393-024-00973-y</identifier><identifier>PMID: 38548864</identifier><language>eng</language><publisher>London: Nature Publishing Group UK</publisher><subject>692/53/2421 ; 692/617/375/1824 ; 692/699/1585/104/1586 ; Adult ; Anatomy ; Biomarkers - blood ; Biomarkers - urine ; Biomedical and Life Sciences ; Biomedicine ; Clearances ; Cohort Studies ; Creatinine ; Creatinine - blood ; Creatinine - urine ; Cystatin C ; Cystatin C - blood ; Epidermal growth factor receptors ; Estimation ; Female ; Glomerular Filtration Rate - physiology ; Human Physiology ; Humans ; Kidney Function Tests - methods ; Male ; Middle Aged ; Neurochemistry ; Neuropsychology ; Neurosciences ; Population studies ; Renal function ; Spinal cord injuries ; Spinal Cord Injuries - blood ; Spinal Cord Injuries - physiopathology ; Spinal Cord Injuries - urine ; Urine ; Young Adult</subject><ispartof>Spinal cord, 2024-06, Vol.62 (6), p.295-299</ispartof><rights>The Author(s), under exclusive licence to International Spinal Cord Society 2024. Springer Nature or its licensor (e.g. a society or other partner) holds exclusive rights to this article under a publishing agreement with the author(s) or other rightsholder(s); author self-archiving of the accepted manuscript version of this article is solely governed by the terms of such publishing agreement and applicable law.</rights><rights>2024. The Author(s), under exclusive licence to International Spinal Cord Society.</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><cites>FETCH-LOGICAL-c326t-4250fef123fd8266932a414a0d19cba3e8639e5423e6e82464437a4ea5ee75f13</cites><orcidid>0000-0002-0015-3563 ; 0009-0007-3528-7768</orcidid></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://link.springer.com/content/pdf/10.1038/s41393-024-00973-y$$EPDF$$P50$$Gspringer$$H</linktopdf><linktohtml>$$Uhttps://link.springer.com/10.1038/s41393-024-00973-y$$EHTML$$P50$$Gspringer$$H</linktohtml><link.rule.ids>314,776,780,27901,27902,41464,42533,51294</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/38548864$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Augustine, Thomas Anand</creatorcontrib><creatorcontrib>M, Henry Prakash</creatorcontrib><creatorcontrib>Alexander, Suceena</creatorcontrib><creatorcontrib>S, Mahasampath Gowri</creatorcontrib><title>Assessment of renal function in persons with motor complete spinal cord injury—cystatin C as an accurate single marker</title><title>Spinal cord</title><addtitle>Spinal Cord</addtitle><addtitle>Spinal Cord</addtitle><description>Study design
Observational cohort.
Aim
To show that Cystatin C is an accurate single marker to estimate GFR in motor complete persons with SCI.
Objectives
To assess if Cystatin C is an accurate for estimating GFR in persons with SCI with no preserved motor power. To study if use of Serum creatinine for estimation of GFR in this population significantly overestimates GFR, thereby inaccurate.
Setting
Tertiary care hospital and Medical College, Vellore, South India.
Methods
30 persons with SCI (ASIA A and B) fulfilling the inclusion criteria were recruited. Serum Creatinine and Serum Cystatin C values were obtained, and eGFR was calculated based on available formulae. 24-h urine for urine creatinine clearance-based eGFR was used as a reference value.
Results
Analysis with a Bland-Atman plot showed that eGFR estimated with Serum Cystatin C was more accurate than Serum Creatinine, using 24-h urine creatinine as a reference value. eGFR using Serum Creatinine significantly overestimated GFR by over 50.6%. Estimated GFR using Serum Cystatin C showed a meager mean difference of 0.5% from the reference 24-h urine creatinine clearance (mean difference of –2.56%).
Conclusion
Serum Cystatin C is a much more accurate marker for estimating GFR in SCI, compared to serum Creatinine which overestimates GFR.</description><subject>692/53/2421</subject><subject>692/617/375/1824</subject><subject>692/699/1585/104/1586</subject><subject>Adult</subject><subject>Anatomy</subject><subject>Biomarkers - blood</subject><subject>Biomarkers - urine</subject><subject>Biomedical and Life Sciences</subject><subject>Biomedicine</subject><subject>Clearances</subject><subject>Cohort Studies</subject><subject>Creatinine</subject><subject>Creatinine - blood</subject><subject>Creatinine - urine</subject><subject>Cystatin C</subject><subject>Cystatin C - blood</subject><subject>Epidermal growth factor receptors</subject><subject>Estimation</subject><subject>Female</subject><subject>Glomerular Filtration Rate - physiology</subject><subject>Human Physiology</subject><subject>Humans</subject><subject>Kidney Function Tests - methods</subject><subject>Male</subject><subject>Middle Aged</subject><subject>Neurochemistry</subject><subject>Neuropsychology</subject><subject>Neurosciences</subject><subject>Population studies</subject><subject>Renal function</subject><subject>Spinal cord injuries</subject><subject>Spinal Cord Injuries - blood</subject><subject>Spinal Cord Injuries - physiopathology</subject><subject>Spinal Cord Injuries - urine</subject><subject>Urine</subject><subject>Young Adult</subject><issn>1362-4393</issn><issn>1476-5624</issn><issn>1476-5624</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2024</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNp90ctO3DAUBmCrAhUKfQEWlSU23aT4FsdZohG9SEjdwNoynhOaIbFTH0eQXR-iT9gnwcPQVmLBypb8_cc6-gk54ewTZ9KcoeKylRUTqmKsbWS1vCGHXDW6qrVQe-UutahUMQfkHeKGFcVb85YcSFMrY7Q6JA_niIA4Qsg0djRBcAPt5uBzHwPtA50gYQxI7_v8g44xx0R9HKcBMlCc-i33Ma0L3cxp-fPrt18wu1ySK-qQukCd93NyW96H2wHo6NIdpGOy37kB4f3zeUSuP19crb5Wl9-_fFudX1ZeCp0rJWrWQceF7NZGaN1K4RRXjq1562-cBKNlC7USEjQYobRSsnEKXA3Q1B2XR-Tjbu6U4s8ZMNuxRw_D4ALEGa1kQtS6abQq9PQF3cQ5lQ23qhHMtA1vixI75VNETNDZKfVlp8VyZre92F0vtvRin3qxSwl9eB4934yw_hf5W0QBcgewPIVbSP__fmXsI2ggmvc</recordid><startdate>20240601</startdate><enddate>20240601</enddate><creator>Augustine, Thomas Anand</creator><creator>M, Henry Prakash</creator><creator>Alexander, Suceena</creator><creator>S, Mahasampath Gowri</creator><general>Nature Publishing Group UK</general><general>Nature Publishing Group</general><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7QL</scope><scope>7T7</scope><scope>7TK</scope><scope>7U9</scope><scope>8FD</scope><scope>C1K</scope><scope>FR3</scope><scope>H94</scope><scope>K9.</scope><scope>M7N</scope><scope>NAPCQ</scope><scope>P64</scope><scope>7X8</scope><orcidid>https://orcid.org/0000-0002-0015-3563</orcidid><orcidid>https://orcid.org/0009-0007-3528-7768</orcidid></search><sort><creationdate>20240601</creationdate><title>Assessment of renal function in persons with motor complete spinal cord injury—cystatin C as an accurate single marker</title><author>Augustine, Thomas Anand ; M, Henry Prakash ; Alexander, Suceena ; S, Mahasampath Gowri</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c326t-4250fef123fd8266932a414a0d19cba3e8639e5423e6e82464437a4ea5ee75f13</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2024</creationdate><topic>692/53/2421</topic><topic>692/617/375/1824</topic><topic>692/699/1585/104/1586</topic><topic>Adult</topic><topic>Anatomy</topic><topic>Biomarkers - blood</topic><topic>Biomarkers - urine</topic><topic>Biomedical and Life Sciences</topic><topic>Biomedicine</topic><topic>Clearances</topic><topic>Cohort Studies</topic><topic>Creatinine</topic><topic>Creatinine - blood</topic><topic>Creatinine - urine</topic><topic>Cystatin C</topic><topic>Cystatin C - blood</topic><topic>Epidermal growth factor receptors</topic><topic>Estimation</topic><topic>Female</topic><topic>Glomerular Filtration Rate - physiology</topic><topic>Human Physiology</topic><topic>Humans</topic><topic>Kidney Function Tests - methods</topic><topic>Male</topic><topic>Middle Aged</topic><topic>Neurochemistry</topic><topic>Neuropsychology</topic><topic>Neurosciences</topic><topic>Population studies</topic><topic>Renal function</topic><topic>Spinal cord injuries</topic><topic>Spinal Cord Injuries - blood</topic><topic>Spinal Cord Injuries - physiopathology</topic><topic>Spinal Cord Injuries - urine</topic><topic>Urine</topic><topic>Young Adult</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Augustine, Thomas Anand</creatorcontrib><creatorcontrib>M, Henry Prakash</creatorcontrib><creatorcontrib>Alexander, Suceena</creatorcontrib><creatorcontrib>S, Mahasampath Gowri</creatorcontrib><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>Bacteriology Abstracts (Microbiology B)</collection><collection>Industrial and Applied Microbiology Abstracts (Microbiology A)</collection><collection>Neurosciences Abstracts</collection><collection>Virology and AIDS Abstracts</collection><collection>Technology Research Database</collection><collection>Environmental Sciences and Pollution Management</collection><collection>Engineering Research Database</collection><collection>AIDS and Cancer Research Abstracts</collection><collection>ProQuest Health & Medical Complete (Alumni)</collection><collection>Algology Mycology and Protozoology Abstracts (Microbiology C)</collection><collection>Nursing & Allied Health Premium</collection><collection>Biotechnology and BioEngineering Abstracts</collection><collection>MEDLINE - Academic</collection><jtitle>Spinal cord</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Augustine, Thomas Anand</au><au>M, Henry Prakash</au><au>Alexander, Suceena</au><au>S, Mahasampath Gowri</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Assessment of renal function in persons with motor complete spinal cord injury—cystatin C as an accurate single marker</atitle><jtitle>Spinal cord</jtitle><stitle>Spinal Cord</stitle><addtitle>Spinal Cord</addtitle><date>2024-06-01</date><risdate>2024</risdate><volume>62</volume><issue>6</issue><spage>295</spage><epage>299</epage><pages>295-299</pages><issn>1362-4393</issn><issn>1476-5624</issn><eissn>1476-5624</eissn><abstract>Study design
Observational cohort.
Aim
To show that Cystatin C is an accurate single marker to estimate GFR in motor complete persons with SCI.
Objectives
To assess if Cystatin C is an accurate for estimating GFR in persons with SCI with no preserved motor power. To study if use of Serum creatinine for estimation of GFR in this population significantly overestimates GFR, thereby inaccurate.
Setting
Tertiary care hospital and Medical College, Vellore, South India.
Methods
30 persons with SCI (ASIA A and B) fulfilling the inclusion criteria were recruited. Serum Creatinine and Serum Cystatin C values were obtained, and eGFR was calculated based on available formulae. 24-h urine for urine creatinine clearance-based eGFR was used as a reference value.
Results
Analysis with a Bland-Atman plot showed that eGFR estimated with Serum Cystatin C was more accurate than Serum Creatinine, using 24-h urine creatinine as a reference value. eGFR using Serum Creatinine significantly overestimated GFR by over 50.6%. Estimated GFR using Serum Cystatin C showed a meager mean difference of 0.5% from the reference 24-h urine creatinine clearance (mean difference of –2.56%).
Conclusion
Serum Cystatin C is a much more accurate marker for estimating GFR in SCI, compared to serum Creatinine which overestimates GFR.</abstract><cop>London</cop><pub>Nature Publishing Group UK</pub><pmid>38548864</pmid><doi>10.1038/s41393-024-00973-y</doi><tpages>5</tpages><orcidid>https://orcid.org/0000-0002-0015-3563</orcidid><orcidid>https://orcid.org/0009-0007-3528-7768</orcidid></addata></record> |
| fulltext | fulltext |
| identifier | ISSN: 1362-4393 |
| ispartof | Spinal cord, 2024-06, Vol.62 (6), p.295-299 |
| issn | 1362-4393 1476-5624 1476-5624 |
| language | eng |
| recordid | cdi_proquest_miscellaneous_3022567764 |
| source | MEDLINE; Springer Nature - Complete Springer Journals |
| subjects | 692/53/2421 692/617/375/1824 692/699/1585/104/1586 Adult Anatomy Biomarkers - blood Biomarkers - urine Biomedical and Life Sciences Biomedicine Clearances Cohort Studies Creatinine Creatinine - blood Creatinine - urine Cystatin C Cystatin C - blood Epidermal growth factor receptors Estimation Female Glomerular Filtration Rate - physiology Human Physiology Humans Kidney Function Tests - methods Male Middle Aged Neurochemistry Neuropsychology Neurosciences Population studies Renal function Spinal cord injuries Spinal Cord Injuries - blood Spinal Cord Injuries - physiopathology Spinal Cord Injuries - urine Urine Young Adult |
| title | Assessment of renal function in persons with motor complete spinal cord injury—cystatin C as an accurate single marker |
| url | https://sfx.bib-bvb.de/sfx_tum?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&ctx_tim=2025-02-09T22%3A59%3A13IST&url_ver=Z39.88-2004&url_ctx_fmt=infofi/fmt:kev:mtx:ctx&rfr_id=info:sid/primo.exlibrisgroup.com:primo3-Article-proquest_cross&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.atitle=Assessment%20of%20renal%20function%20in%20persons%20with%20motor%20complete%20spinal%20cord%20injury%E2%80%94cystatin%20C%20as%20an%20accurate%20single%20marker&rft.jtitle=Spinal%20cord&rft.au=Augustine,%20Thomas%20Anand&rft.date=2024-06-01&rft.volume=62&rft.issue=6&rft.spage=295&rft.epage=299&rft.pages=295-299&rft.issn=1362-4393&rft.eissn=1476-5624&rft_id=info:doi/10.1038/s41393-024-00973-y&rft_dat=%3Cproquest_cross%3E3072089719%3C/proquest_cross%3E%3Curl%3E%3C/url%3E&disable_directlink=true&sfx.directlink=off&sfx.report_link=0&rft_id=info:oai/&rft_pqid=3072089719&rft_id=info:pmid/38548864&rfr_iscdi=true |