Targeting STING elicits GSDMD-dependent pyroptosis and boosts anti-tumor immunity in renal cell carcinoma

s While Stimulator-of-interferon genes (STING) is an innate immune adapter cruicial for sensing cytosolic DNA and modulating immune microenvironment, its tumor-promoting role in tumor survival and immune evasion remains largely unknown. Here we reported that renal cancer cells are exceptionally depe...

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Veröffentlicht in:	Oncogene 2024-05, Vol.43 (20), p.1534-1548
Hauptverfasser:	Wu, Shengpan, Wang, Baojun, Li, Hongzhao, Wang, Hanfeng, Du, Songliang, Huang, Xing, Fan, Yang, Gao, Yu, Gu, Liangyou, Huang, Qingbo, Chen, Jianjun, Zhang, Xu, Huang, Yan, Ma, Xin
Format:	Artikel
Sprache:	eng
Schlagworte:	13/1 13/105 13/106 14/63 38/1 38/109 45/22 631/67/589/1588/1351 631/67/69 64/60 82/80 Activating Transcription Factor 4 - genetics Activating Transcription Factor 4 - metabolism Animals Apoptosis Carcinoma, Renal Cell - genetics Carcinoma, Renal Cell - immunology Carcinoma, Renal Cell - metabolism Carcinoma, Renal Cell - pathology Caspase-8 CD4 antigen CD8 antigen Cell activation Cell Biology Cell Line, Tumor Clear cell-type renal cell carcinoma Gasdermins Human Genetics Humans Immunity Immunosurveillance Internal Medicine Intracellular Signaling Peptides and Proteins - genetics Intracellular Signaling Peptides and Proteins - metabolism Kidney cancer Kidney Neoplasms - genetics Kidney Neoplasms - immunology Kidney Neoplasms - metabolism Kidney Neoplasms - pathology Lymphocytes T Medicine Medicine & Public Health Membrane Proteins - genetics Membrane Proteins - metabolism Metastases Mice Microenvironments Oncology Phosphate-Binding Proteins - genetics Phosphate-Binding Proteins - metabolism Pyroptosis Signal Transduction Transcription Factor CHOP - genetics Transcription Factor CHOP - metabolism Tumors
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