Fructose-1,6-bisphosphatase 1 dephosphorylates and inhibits TERT for tumor suppression

Telomere dysfunction is intricately linked to the aging process and stands out as a prominent cancer hallmark. Here we demonstrate that telomerase activity is differentially regulated in cancer and normal cells depending on the expression status of fructose-1,6-bisphosphatase 1 (FBP1). In FBP1-expre...

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Veröffentlicht in:	Nature chemical biology 2024-11, Vol.20 (11), p.1505-1513
Hauptverfasser:	Li, Min, Wang, Zheng, Tao, Jingjing, Jiang, Hongfei, Yang, Huang, Guo, Dong, Zhao, Hong, He, Xuxiao, Luo, Shudi, Jiang, Xiaoming, Yuan, Li, Xiao, Liwei, He, Haiyan, Yu, Rilei, Fang, Jing, Liang, Tingbo, Mao, Zhengwei, Xu, Daqian, Lu, Zhimin
Format:	Artikel
Sprache:	eng
Schlagworte:	631/337/1427 631/67/1059 631/92/458 639/301/54 Animals Biochemical Engineering Biochemistry Bioorganic Chemistry Carcinoma, Hepatocellular - genetics Carcinoma, Hepatocellular - metabolism Carcinoma, Hepatocellular - pathology Cell Biology Cell Line, Tumor Cell Proliferation Chemistry Chemistry and Materials Science Chemistry/Food Science Fructose Fructose-Bisphosphatase - antagonists & inhibitors Fructose-Bisphosphatase - genetics Fructose-Bisphosphatase - metabolism Gene expression Hepatocellular carcinoma Hepatocytes Humans Lipids Liver Neoplasms - metabolism Liver Neoplasms - pathology Mice Mice, Nude Nanoparticles Nuclear transport Phosphatase Phosphorylation Protein deficiency Protein phosphatase Protein transport Proteins Renal cell carcinoma RNA-directed DNA polymerase Senescence Telomerase Telomerase - antagonists & inhibitors Telomerase - genetics Telomerase - metabolism Telomerase reverse transcriptase Telomeres Translocation Tumor cells Tumor suppression Tumors
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