TRBC1-targeting antibody–drug conjugates for the treatment of T cell cancers

Antibody and chimeric antigen receptor (CAR) T cell-mediated targeted therapies have improved survival in patients with solid and haematologic malignancies 1 – 9 . Adults with T cell leukaemias and lymphomas, collectively called T cell cancers, have short survival 10 , 11 and lack such targeted ther...

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Veröffentlicht in:	Nature (London) 2024-04, Vol.628 (8007), p.416-423
Hauptverfasser:	Nichakawade, Tushar D., Ge, Jiaxin, Mog, Brian J., Lee, Bum Seok, Pearlman, Alexander H., Hwang, Michael S., DiNapoli, Sarah R., Wyhs, Nicolas, Marcou, Nikita, Glavaris, Stephanie, Konig, Maximilian F., Gabelli, Sandra B., Watson, Evangeline, Sterling, Cole, Wagner-Johnston, Nina, Rozati, Sima, Swinnen, Lode, Fuchs, Ephraim, Pardoll, Drew M., Gabrielson, Kathy, Papadopoulos, Nickolas, Bettegowda, Chetan, Kinzler, Kenneth W., Zhou, Shibin, Sur, Surojit, Vogelstein, Bert, Paul, Suman
Format:	Artikel
Sprache:	eng
Schlagworte:	13/1 13/31 14/19 59/5 631/67/1059/153 631/67/1059/2325 631/67/1059/602 82/58 82/83 Animal models Antibodies Antigens Blood cancer Cancer Cell culture Chimeric antigen receptors Clinical trials Conjugates Constant region Cytotoxicity Drugs Humanities and Social Sciences Leukemia Lymphocytes Lymphocytes T Lymphoma multidisciplinary Patients Receptors Science Science (multidisciplinary) T cell receptors
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