A novel degradable poly(β-amino ester) and its nano-complex with poly(acrylic acid)
A novel degradable cationic polymer with discrete charge based on water-soluble poly(β-amino ester) was synthesized by Michael addition of tetraethylene pentamine (TEPA) to ethylene glycol diacrylate (EGDA), which is denoted as PTE. There are primary, secondary and tertiary amines in PTE molecule as...
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Veröffentlicht in: | Polymer (Guilford) 2007-10, Vol.48 (21), p.6272-6285 |
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description | A novel degradable cationic polymer with discrete charge based on water-soluble poly(β-amino ester) was synthesized by Michael addition of tetraethylene pentamine (TEPA) to ethylene glycol diacrylate (EGDA), which is denoted as PTE. There are primary, secondary and tertiary amines in PTE molecule as branched polyethylenimine. The nitrogen content of PTE is 13.9mmol/g at molar feed ratio of 1:1, lower than that of polyethylenimine of 23mmol/g, so PTE is a polycation with discrete charge relative to polyethylenimine with excess high charge density. Acid–base titration indicated that PTE was protonated in the ranges from both pH 5.0 to pH 7.4 and pH 7.4 to pH 11. The changes of pH, viscosity and 1H NMR spectra showed that PTE was degraded in water first rapidly and then slowly. In aqueous solution, PTE self-assembled with weak anionic polymer, poly(acrylic acid) (PAA), into nanoparticles. The particle size first increased and then decreased with increasing the mass ratio of PTE to PAA, which is defined as θ, from 0.1 to 2. At θ of more than 0.8 or less than 0.6, complex particles with diameter less than 200nm were obtained. At θ of 0.8, the UV–vis absorbance of complex solution at first day was obviously higher than that at seventh day, while at θ of 0.2, two absorbance curves at these two time points were almost superimposed, indicating that small complex particles were more stable than large ones because of electrostatic repulsion. |
doi_str_mv | 10.1016/j.polymer.2007.08.026 |
format | Article |
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There are primary, secondary and tertiary amines in PTE molecule as branched polyethylenimine. The nitrogen content of PTE is 13.9mmol/g at molar feed ratio of 1:1, lower than that of polyethylenimine of 23mmol/g, so PTE is a polycation with discrete charge relative to polyethylenimine with excess high charge density. Acid–base titration indicated that PTE was protonated in the ranges from both pH 5.0 to pH 7.4 and pH 7.4 to pH 11. The changes of pH, viscosity and 1H NMR spectra showed that PTE was degraded in water first rapidly and then slowly. In aqueous solution, PTE self-assembled with weak anionic polymer, poly(acrylic acid) (PAA), into nanoparticles. The particle size first increased and then decreased with increasing the mass ratio of PTE to PAA, which is defined as θ, from 0.1 to 2. At θ of more than 0.8 or less than 0.6, complex particles with diameter less than 200nm were obtained. At θ of 0.8, the UV–vis absorbance of complex solution at first day was obviously higher than that at seventh day, while at θ of 0.2, two absorbance curves at these two time points were almost superimposed, indicating that small complex particles were more stable than large ones because of electrostatic repulsion.</description><identifier>ISSN: 0032-3861</identifier><identifier>EISSN: 1873-2291</identifier><identifier>DOI: 10.1016/j.polymer.2007.08.026</identifier><identifier>CODEN: POLMAG</identifier><language>eng</language><publisher>Oxford: Elsevier Ltd</publisher><subject>Applied sciences ; Complex ; Degradable ; Exact sciences and technology ; Organic polymers ; Physicochemistry of polymers ; Poly(β-amino ester) ; Polycondensation ; Preparation, kinetics, thermodynamics, mechanism and catalysts</subject><ispartof>Polymer (Guilford), 2007-10, Vol.48 (21), p.6272-6285</ispartof><rights>2007 Elsevier Ltd</rights><rights>2007 INIST-CNRS</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c370t-75b8d9ef27dda804e2346725d5a1a88efab107451a0c69c9de51d15be5b99dfd3</citedby><cites>FETCH-LOGICAL-c370t-75b8d9ef27dda804e2346725d5a1a88efab107451a0c69c9de51d15be5b99dfd3</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktohtml>$$Uhttps://dx.doi.org/10.1016/j.polymer.2007.08.026$$EHTML$$P50$$Gelsevier$$H</linktohtml><link.rule.ids>314,780,784,3550,27924,27925,45995</link.rule.ids><backlink>$$Uhttp://pascal-francis.inist.fr/vibad/index.php?action=getRecordDetail&idt=19127468$$DView record in Pascal Francis$$Hfree_for_read</backlink></links><search><creatorcontrib>Wu, Chuan-bao</creatorcontrib><creatorcontrib>Hao, Jian-yuan</creatorcontrib><creatorcontrib>Deng, Xian-mo</creatorcontrib><title>A novel degradable poly(β-amino ester) and its nano-complex with poly(acrylic acid)</title><title>Polymer (Guilford)</title><description>A novel degradable cationic polymer with discrete charge based on water-soluble poly(β-amino ester) was synthesized by Michael addition of tetraethylene pentamine (TEPA) to ethylene glycol diacrylate (EGDA), which is denoted as PTE. There are primary, secondary and tertiary amines in PTE molecule as branched polyethylenimine. The nitrogen content of PTE is 13.9mmol/g at molar feed ratio of 1:1, lower than that of polyethylenimine of 23mmol/g, so PTE is a polycation with discrete charge relative to polyethylenimine with excess high charge density. Acid–base titration indicated that PTE was protonated in the ranges from both pH 5.0 to pH 7.4 and pH 7.4 to pH 11. The changes of pH, viscosity and 1H NMR spectra showed that PTE was degraded in water first rapidly and then slowly. In aqueous solution, PTE self-assembled with weak anionic polymer, poly(acrylic acid) (PAA), into nanoparticles. The particle size first increased and then decreased with increasing the mass ratio of PTE to PAA, which is defined as θ, from 0.1 to 2. At θ of more than 0.8 or less than 0.6, complex particles with diameter less than 200nm were obtained. At θ of 0.8, the UV–vis absorbance of complex solution at first day was obviously higher than that at seventh day, while at θ of 0.2, two absorbance curves at these two time points were almost superimposed, indicating that small complex particles were more stable than large ones because of electrostatic repulsion.</description><subject>Applied sciences</subject><subject>Complex</subject><subject>Degradable</subject><subject>Exact sciences and technology</subject><subject>Organic polymers</subject><subject>Physicochemistry of polymers</subject><subject>Poly(β-amino ester)</subject><subject>Polycondensation</subject><subject>Preparation, kinetics, thermodynamics, mechanism and catalysts</subject><issn>0032-3861</issn><issn>1873-2291</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2007</creationdate><recordtype>article</recordtype><recordid>eNqFkMFu1DAQhi0EEkvpI1TyBUQPCWMnTuwTqiqgSJW4tGdrYk_AKyde7LRlX4sH6TOR1a7EkdNcvvn_mY-xCwG1ANF93Na7FPcT5VoC9DXoGmT3gm2E7ptKSiNesg1AI6tGd-I1e1PKFgCkku2G3V3xOT1S5J5-ZPQ4ROKHtA_Pfyqcwpw4lYXyJcfZ87AUPuOcKpemXaTf_CksP484uryPwXF0wV--Za9GjIXOT_OM3X_5fHd9U91-__rt-uq2ck0PS9WrQXtDo-y9Rw0tyabteqm8QoFa04iDgL5VAsF1xhlPSnihBlKDMX70zRl7f8zd5fTrYT3UTqE4ihFnSg_FNiCEMY1cQXUEXU6lZBrtLocJ894KsAeHdmtPDu3BoQVtV4fr3rtTARaHccw4u1D-LRsh-7bTK_fpyNH67WNYU4oLNDvyIZNbrE_hP01_Adz1i3Q</recordid><startdate>20071005</startdate><enddate>20071005</enddate><creator>Wu, Chuan-bao</creator><creator>Hao, Jian-yuan</creator><creator>Deng, Xian-mo</creator><general>Elsevier Ltd</general><general>Elsevier</general><scope>IQODW</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7SR</scope><scope>8FD</scope><scope>F28</scope><scope>FR3</scope><scope>JG9</scope></search><sort><creationdate>20071005</creationdate><title>A novel degradable poly(β-amino ester) and its nano-complex with poly(acrylic acid)</title><author>Wu, Chuan-bao ; Hao, Jian-yuan ; Deng, Xian-mo</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c370t-75b8d9ef27dda804e2346725d5a1a88efab107451a0c69c9de51d15be5b99dfd3</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2007</creationdate><topic>Applied sciences</topic><topic>Complex</topic><topic>Degradable</topic><topic>Exact sciences and technology</topic><topic>Organic polymers</topic><topic>Physicochemistry of polymers</topic><topic>Poly(β-amino ester)</topic><topic>Polycondensation</topic><topic>Preparation, kinetics, thermodynamics, mechanism and catalysts</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Wu, Chuan-bao</creatorcontrib><creatorcontrib>Hao, Jian-yuan</creatorcontrib><creatorcontrib>Deng, Xian-mo</creatorcontrib><collection>Pascal-Francis</collection><collection>CrossRef</collection><collection>Engineered Materials Abstracts</collection><collection>Technology Research Database</collection><collection>ANTE: Abstracts in New Technology & Engineering</collection><collection>Engineering Research Database</collection><collection>Materials Research Database</collection><jtitle>Polymer (Guilford)</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Wu, Chuan-bao</au><au>Hao, Jian-yuan</au><au>Deng, Xian-mo</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>A novel degradable poly(β-amino ester) and its nano-complex with poly(acrylic acid)</atitle><jtitle>Polymer (Guilford)</jtitle><date>2007-10-05</date><risdate>2007</risdate><volume>48</volume><issue>21</issue><spage>6272</spage><epage>6285</epage><pages>6272-6285</pages><issn>0032-3861</issn><eissn>1873-2291</eissn><coden>POLMAG</coden><abstract>A novel degradable cationic polymer with discrete charge based on water-soluble poly(β-amino ester) was synthesized by Michael addition of tetraethylene pentamine (TEPA) to ethylene glycol diacrylate (EGDA), which is denoted as PTE. There are primary, secondary and tertiary amines in PTE molecule as branched polyethylenimine. The nitrogen content of PTE is 13.9mmol/g at molar feed ratio of 1:1, lower than that of polyethylenimine of 23mmol/g, so PTE is a polycation with discrete charge relative to polyethylenimine with excess high charge density. Acid–base titration indicated that PTE was protonated in the ranges from both pH 5.0 to pH 7.4 and pH 7.4 to pH 11. The changes of pH, viscosity and 1H NMR spectra showed that PTE was degraded in water first rapidly and then slowly. In aqueous solution, PTE self-assembled with weak anionic polymer, poly(acrylic acid) (PAA), into nanoparticles. The particle size first increased and then decreased with increasing the mass ratio of PTE to PAA, which is defined as θ, from 0.1 to 2. At θ of more than 0.8 or less than 0.6, complex particles with diameter less than 200nm were obtained. At θ of 0.8, the UV–vis absorbance of complex solution at first day was obviously higher than that at seventh day, while at θ of 0.2, two absorbance curves at these two time points were almost superimposed, indicating that small complex particles were more stable than large ones because of electrostatic repulsion.</abstract><cop>Oxford</cop><pub>Elsevier Ltd</pub><doi>10.1016/j.polymer.2007.08.026</doi><tpages>14</tpages></addata></record> |
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subjects | Applied sciences Complex Degradable Exact sciences and technology Organic polymers Physicochemistry of polymers Poly(β-amino ester) Polycondensation Preparation, kinetics, thermodynamics, mechanism and catalysts |
title | A novel degradable poly(β-amino ester) and its nano-complex with poly(acrylic acid) |
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