Investigation of the degradation behaviour of poly(ethylene glycol- co- d, l-lactide) copolymer
The aim was to investigate the degradation behaviour of poly(ethylene glycol- co- d, l-lactide) (PEG- d, l-PLA) multiblock copolymer, in bulk and as microspheres, in aqueous medium. The degradation behaviour of PLA homopolymers in bulk and microspheres was evaluated as comparison. Microsphere prepar...
Gespeichert in:
| Veröffentlicht in: | Polymer degradation and stability 2007-09, Vol.92 (9), p.1660-1668 |
|---|---|
| Hauptverfasser: | , , , , , , |
| Format: | Artikel |
| Sprache: | eng |
| Schlagworte: | |
| Online-Zugang: | Volltext |
| Tags: |
Tag hinzufügen
Keine Tags, Fügen Sie den ersten Tag hinzu!
|
| container_end_page | 1668 |
|---|---|
| container_issue | 9 |
| container_start_page | 1660 |
| container_title | Polymer degradation and stability |
| container_volume | 92 |
| creator | Dorati, Rossella Genta, Ida Colonna, Claudia Modena, Tiziana Pavanetto, Franca Perugini, Paola Conti, Bice |
| description | The aim was to investigate the degradation behaviour of poly(ethylene glycol-
co-
d,
l-lactide) (PEG-
d,
l-PLA) multiblock copolymer, in bulk and as microspheres, in aqueous medium. The degradation behaviour of PLA homopolymers in bulk and microspheres was evaluated as comparison.
Microsphere preparation was performed by the double emulsion solvent evaporation method. Physical–chemical characterization of the raw polymers and the microspheres was performed by nuclear magnetic resonance (NMR) and modulated differential scanning calorimetry (MDSC). Polymer molecular weight, before and after incubation in aqueous environment, was evaluated by GPC; water uptake and mass loss were determined gravimetrically.
The presence of PEG segments inside PLA chains gave a characteristic spongy structure to the microspheres. A significant increase in polymer
T
g values was found for the microsphere formulations compared to polymer in bulk. After 63 days of incubation in the aqueous environment, the PEG-
d,
l-PLA microspheres achieved an average
M
w reduction of 47% compared to 20% for PLA microspheres. The corresponding
M
w decrease of the polymers in bulk was significantly higher: 72% and 41% for PEG-
d,
l-PLA and PLA, respectively.
The data show how the degradation behaviour of polymer in bulk in an aqueous environment is significantly different from the behaviour of the corresponding microspheres. These results highlight the importance of performing a thorough physical–chemical characterization on microsphere formulations. |
| doi_str_mv | 10.1016/j.polymdegradstab.2007.06.020 |
| format | Article |
| fullrecord | <record><control><sourceid>proquest_cross</sourceid><recordid>TN_cdi_proquest_miscellaneous_30119776</recordid><sourceformat>XML</sourceformat><sourcesystem>PC</sourcesystem><els_id>S0141391007002029</els_id><sourcerecordid>30119776</sourcerecordid><originalsourceid>FETCH-LOGICAL-c394t-a784b404caef8ae1d724f8e977991882469a09c716597062863e97b966c583bb3</originalsourceid><addsrcrecordid>eNqNUMFq4zAQFaULTbP9B19aWlh7R7YsWYceSmjTQmEvu2chy-NEQbFSyQnk76usC4WeOpeBeW_em3mEXFMoKFD-e1PsvDtuO1wF3cVRt0UJIArgBZRwRma0EVVeViU9JzOgjOaVpHBBLmPcQCpW0xlRL8MB42hXerR-yHyfjWvMJslp1OJaH6zfhxN4MrzFcX10OGC2ckfjXZ4Zn2fdr8zlTpvRdniXJv9Pw_CT_Oi1i3j10efk39Pj38Vz_vpn-bJ4eM1NJdmYa9GwlgEzGvtGI-1EyfoGpRBS0qYpGZcapBGU11IALxteJbCVnJu6qdq2mpObSXcX_Ns-faS2Nhp0Tg_o91FVQGlS44l4PxFN8DEG7NUu2K0OR0VBnWJVG_UlVnWKVQFXKda0f_1hpKPRrg96MDZ-ikgQNRN14i0nHqavDxaDisbiYLCzAc2oOm-_6fgOzUSXaQ</addsrcrecordid><sourcetype>Aggregation Database</sourcetype><iscdi>true</iscdi><recordtype>article</recordtype><pqid>30119776</pqid></control><display><type>article</type><title>Investigation of the degradation behaviour of poly(ethylene glycol- co- d, l-lactide) copolymer</title><source>Elsevier ScienceDirect Journals</source><creator>Dorati, Rossella ; Genta, Ida ; Colonna, Claudia ; Modena, Tiziana ; Pavanetto, Franca ; Perugini, Paola ; Conti, Bice</creator><creatorcontrib>Dorati, Rossella ; Genta, Ida ; Colonna, Claudia ; Modena, Tiziana ; Pavanetto, Franca ; Perugini, Paola ; Conti, Bice</creatorcontrib><description>The aim was to investigate the degradation behaviour of poly(ethylene glycol-
co-
d,
l-lactide) (PEG-
d,
l-PLA) multiblock copolymer, in bulk and as microspheres, in aqueous medium. The degradation behaviour of PLA homopolymers in bulk and microspheres was evaluated as comparison.
Microsphere preparation was performed by the double emulsion solvent evaporation method. Physical–chemical characterization of the raw polymers and the microspheres was performed by nuclear magnetic resonance (NMR) and modulated differential scanning calorimetry (MDSC). Polymer molecular weight, before and after incubation in aqueous environment, was evaluated by GPC; water uptake and mass loss were determined gravimetrically.
The presence of PEG segments inside PLA chains gave a characteristic spongy structure to the microspheres. A significant increase in polymer
T
g values was found for the microsphere formulations compared to polymer in bulk. After 63 days of incubation in the aqueous environment, the PEG-
d,
l-PLA microspheres achieved an average
M
w reduction of 47% compared to 20% for PLA microspheres. The corresponding
M
w decrease of the polymers in bulk was significantly higher: 72% and 41% for PEG-
d,
l-PLA and PLA, respectively.
The data show how the degradation behaviour of polymer in bulk in an aqueous environment is significantly different from the behaviour of the corresponding microspheres. These results highlight the importance of performing a thorough physical–chemical characterization on microsphere formulations.</description><identifier>ISSN: 0141-3910</identifier><identifier>EISSN: 1873-2321</identifier><identifier>DOI: 10.1016/j.polymdegradstab.2007.06.020</identifier><identifier>CODEN: PDSTDW</identifier><language>eng</language><publisher>Oxford: Elsevier Ltd</publisher><subject>Applied sciences ; Biodegradable polymers ; Biological and medical sciences ; Block copolymer ; Chemical reactions and properties ; Degradation ; Drug delivery systems ; Exact sciences and technology ; General pharmacology ; Medical sciences ; Organic polymers ; Pharmaceutical technology. Pharmaceutical industry ; Pharmacology. Drug treatments ; Physicochemistry of polymers ; Polyethylene glycol- co-polylactide ; Polylactide</subject><ispartof>Polymer degradation and stability, 2007-09, Vol.92 (9), p.1660-1668</ispartof><rights>2007 Elsevier Ltd</rights><rights>2008 INIST-CNRS</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c394t-a784b404caef8ae1d724f8e977991882469a09c716597062863e97b966c583bb3</citedby><cites>FETCH-LOGICAL-c394t-a784b404caef8ae1d724f8e977991882469a09c716597062863e97b966c583bb3</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktohtml>$$Uhttps://www.sciencedirect.com/science/article/pii/S0141391007002029$$EHTML$$P50$$Gelsevier$$H</linktohtml><link.rule.ids>314,776,780,3537,27901,27902,65306</link.rule.ids><backlink>$$Uhttp://pascal-francis.inist.fr/vibad/index.php?action=getRecordDetail&idt=19075475$$DView record in Pascal Francis$$Hfree_for_read</backlink></links><search><creatorcontrib>Dorati, Rossella</creatorcontrib><creatorcontrib>Genta, Ida</creatorcontrib><creatorcontrib>Colonna, Claudia</creatorcontrib><creatorcontrib>Modena, Tiziana</creatorcontrib><creatorcontrib>Pavanetto, Franca</creatorcontrib><creatorcontrib>Perugini, Paola</creatorcontrib><creatorcontrib>Conti, Bice</creatorcontrib><title>Investigation of the degradation behaviour of poly(ethylene glycol- co- d, l-lactide) copolymer</title><title>Polymer degradation and stability</title><description>The aim was to investigate the degradation behaviour of poly(ethylene glycol-
co-
d,
l-lactide) (PEG-
d,
l-PLA) multiblock copolymer, in bulk and as microspheres, in aqueous medium. The degradation behaviour of PLA homopolymers in bulk and microspheres was evaluated as comparison.
Microsphere preparation was performed by the double emulsion solvent evaporation method. Physical–chemical characterization of the raw polymers and the microspheres was performed by nuclear magnetic resonance (NMR) and modulated differential scanning calorimetry (MDSC). Polymer molecular weight, before and after incubation in aqueous environment, was evaluated by GPC; water uptake and mass loss were determined gravimetrically.
The presence of PEG segments inside PLA chains gave a characteristic spongy structure to the microspheres. A significant increase in polymer
T
g values was found for the microsphere formulations compared to polymer in bulk. After 63 days of incubation in the aqueous environment, the PEG-
d,
l-PLA microspheres achieved an average
M
w reduction of 47% compared to 20% for PLA microspheres. The corresponding
M
w decrease of the polymers in bulk was significantly higher: 72% and 41% for PEG-
d,
l-PLA and PLA, respectively.
The data show how the degradation behaviour of polymer in bulk in an aqueous environment is significantly different from the behaviour of the corresponding microspheres. These results highlight the importance of performing a thorough physical–chemical characterization on microsphere formulations.</description><subject>Applied sciences</subject><subject>Biodegradable polymers</subject><subject>Biological and medical sciences</subject><subject>Block copolymer</subject><subject>Chemical reactions and properties</subject><subject>Degradation</subject><subject>Drug delivery systems</subject><subject>Exact sciences and technology</subject><subject>General pharmacology</subject><subject>Medical sciences</subject><subject>Organic polymers</subject><subject>Pharmaceutical technology. Pharmaceutical industry</subject><subject>Pharmacology. Drug treatments</subject><subject>Physicochemistry of polymers</subject><subject>Polyethylene glycol- co-polylactide</subject><subject>Polylactide</subject><issn>0141-3910</issn><issn>1873-2321</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2007</creationdate><recordtype>article</recordtype><recordid>eNqNUMFq4zAQFaULTbP9B19aWlh7R7YsWYceSmjTQmEvu2chy-NEQbFSyQnk76usC4WeOpeBeW_em3mEXFMoKFD-e1PsvDtuO1wF3cVRt0UJIArgBZRwRma0EVVeViU9JzOgjOaVpHBBLmPcQCpW0xlRL8MB42hXerR-yHyfjWvMJslp1OJaH6zfhxN4MrzFcX10OGC2ckfjXZ4Zn2fdr8zlTpvRdniXJv9Pw_CT_Oi1i3j10efk39Pj38Vz_vpn-bJ4eM1NJdmYa9GwlgEzGvtGI-1EyfoGpRBS0qYpGZcapBGU11IALxteJbCVnJu6qdq2mpObSXcX_Ns-faS2Nhp0Tg_o91FVQGlS44l4PxFN8DEG7NUu2K0OR0VBnWJVG_UlVnWKVQFXKda0f_1hpKPRrg96MDZ-ikgQNRN14i0nHqavDxaDisbiYLCzAc2oOm-_6fgOzUSXaQ</recordid><startdate>20070901</startdate><enddate>20070901</enddate><creator>Dorati, Rossella</creator><creator>Genta, Ida</creator><creator>Colonna, Claudia</creator><creator>Modena, Tiziana</creator><creator>Pavanetto, Franca</creator><creator>Perugini, Paola</creator><creator>Conti, Bice</creator><general>Elsevier Ltd</general><general>Elsevier Science</general><scope>IQODW</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7SR</scope><scope>8FD</scope><scope>JG9</scope></search><sort><creationdate>20070901</creationdate><title>Investigation of the degradation behaviour of poly(ethylene glycol- co- d, l-lactide) copolymer</title><author>Dorati, Rossella ; Genta, Ida ; Colonna, Claudia ; Modena, Tiziana ; Pavanetto, Franca ; Perugini, Paola ; Conti, Bice</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c394t-a784b404caef8ae1d724f8e977991882469a09c716597062863e97b966c583bb3</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2007</creationdate><topic>Applied sciences</topic><topic>Biodegradable polymers</topic><topic>Biological and medical sciences</topic><topic>Block copolymer</topic><topic>Chemical reactions and properties</topic><topic>Degradation</topic><topic>Drug delivery systems</topic><topic>Exact sciences and technology</topic><topic>General pharmacology</topic><topic>Medical sciences</topic><topic>Organic polymers</topic><topic>Pharmaceutical technology. Pharmaceutical industry</topic><topic>Pharmacology. Drug treatments</topic><topic>Physicochemistry of polymers</topic><topic>Polyethylene glycol- co-polylactide</topic><topic>Polylactide</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Dorati, Rossella</creatorcontrib><creatorcontrib>Genta, Ida</creatorcontrib><creatorcontrib>Colonna, Claudia</creatorcontrib><creatorcontrib>Modena, Tiziana</creatorcontrib><creatorcontrib>Pavanetto, Franca</creatorcontrib><creatorcontrib>Perugini, Paola</creatorcontrib><creatorcontrib>Conti, Bice</creatorcontrib><collection>Pascal-Francis</collection><collection>CrossRef</collection><collection>Engineered Materials Abstracts</collection><collection>Technology Research Database</collection><collection>Materials Research Database</collection><jtitle>Polymer degradation and stability</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Dorati, Rossella</au><au>Genta, Ida</au><au>Colonna, Claudia</au><au>Modena, Tiziana</au><au>Pavanetto, Franca</au><au>Perugini, Paola</au><au>Conti, Bice</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Investigation of the degradation behaviour of poly(ethylene glycol- co- d, l-lactide) copolymer</atitle><jtitle>Polymer degradation and stability</jtitle><date>2007-09-01</date><risdate>2007</risdate><volume>92</volume><issue>9</issue><spage>1660</spage><epage>1668</epage><pages>1660-1668</pages><issn>0141-3910</issn><eissn>1873-2321</eissn><coden>PDSTDW</coden><abstract>The aim was to investigate the degradation behaviour of poly(ethylene glycol-
co-
d,
l-lactide) (PEG-
d,
l-PLA) multiblock copolymer, in bulk and as microspheres, in aqueous medium. The degradation behaviour of PLA homopolymers in bulk and microspheres was evaluated as comparison.
Microsphere preparation was performed by the double emulsion solvent evaporation method. Physical–chemical characterization of the raw polymers and the microspheres was performed by nuclear magnetic resonance (NMR) and modulated differential scanning calorimetry (MDSC). Polymer molecular weight, before and after incubation in aqueous environment, was evaluated by GPC; water uptake and mass loss were determined gravimetrically.
The presence of PEG segments inside PLA chains gave a characteristic spongy structure to the microspheres. A significant increase in polymer
T
g values was found for the microsphere formulations compared to polymer in bulk. After 63 days of incubation in the aqueous environment, the PEG-
d,
l-PLA microspheres achieved an average
M
w reduction of 47% compared to 20% for PLA microspheres. The corresponding
M
w decrease of the polymers in bulk was significantly higher: 72% and 41% for PEG-
d,
l-PLA and PLA, respectively.
The data show how the degradation behaviour of polymer in bulk in an aqueous environment is significantly different from the behaviour of the corresponding microspheres. These results highlight the importance of performing a thorough physical–chemical characterization on microsphere formulations.</abstract><cop>Oxford</cop><pub>Elsevier Ltd</pub><doi>10.1016/j.polymdegradstab.2007.06.020</doi><tpages>9</tpages></addata></record> |
| fulltext | fulltext |
| identifier | ISSN: 0141-3910 |
| ispartof | Polymer degradation and stability, 2007-09, Vol.92 (9), p.1660-1668 |
| issn | 0141-3910 1873-2321 |
| language | eng |
| recordid | cdi_proquest_miscellaneous_30119776 |
| source | Elsevier ScienceDirect Journals |
| subjects | Applied sciences Biodegradable polymers Biological and medical sciences Block copolymer Chemical reactions and properties Degradation Drug delivery systems Exact sciences and technology General pharmacology Medical sciences Organic polymers Pharmaceutical technology. Pharmaceutical industry Pharmacology. Drug treatments Physicochemistry of polymers Polyethylene glycol- co-polylactide Polylactide |
| title | Investigation of the degradation behaviour of poly(ethylene glycol- co- d, l-lactide) copolymer |
| url | https://sfx.bib-bvb.de/sfx_tum?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&ctx_tim=2025-01-30T14%3A17%3A02IST&url_ver=Z39.88-2004&url_ctx_fmt=infofi/fmt:kev:mtx:ctx&rfr_id=info:sid/primo.exlibrisgroup.com:primo3-Article-proquest_cross&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.atitle=Investigation%20of%20the%20degradation%20behaviour%20of%20poly(ethylene%20glycol-%20co-%20d,%20l-lactide)%20copolymer&rft.jtitle=Polymer%20degradation%20and%20stability&rft.au=Dorati,%20Rossella&rft.date=2007-09-01&rft.volume=92&rft.issue=9&rft.spage=1660&rft.epage=1668&rft.pages=1660-1668&rft.issn=0141-3910&rft.eissn=1873-2321&rft.coden=PDSTDW&rft_id=info:doi/10.1016/j.polymdegradstab.2007.06.020&rft_dat=%3Cproquest_cross%3E30119776%3C/proquest_cross%3E%3Curl%3E%3C/url%3E&disable_directlink=true&sfx.directlink=off&sfx.report_link=0&rft_id=info:oai/&rft_pqid=30119776&rft_id=info:pmid/&rft_els_id=S0141391007002029&rfr_iscdi=true |