Controlled Release of DNA from Self-Degrading Microcapsules

Controlled Release of DNA from Self-Degrading Microcapsules

Self‐disintegrating microcapsules were prepared by encapsulating a highly active mix of proteases (Pronase®) into biodegradable polyelectrolyte shells. Pronase was captured by micron‐sized calcium carbonate particles that were subsequently embedded into onion‐like shells of poly(L‐arginine) and poly...

Ausführliche Beschreibung

Gespeichert in:
Bibliographische Detailangaben
Veröffentlicht in:Macromolecular rapid communications. 2007-09, Vol.28 (18-19), p.1894-1899
Hauptverfasser: Borodina, Tatiana, Markvicheva, Elena, Kunizhev, Stanislav, Möhwald, Helmuth, Sukhorukov, Gleb B., Kreft, Oliver
Format: Artikel
Sprache:eng
Schlagworte:
biodegradable polymers
DNA
drug delivery systems
enzymes
microencapsulation
Online-Zugang:Volltext
Tags: Tag hinzufügen
Keine Tags, Fügen Sie den ersten Tag hinzu!
container_end_page 1899
container_issue 18-19
container_start_page 1894
container_title Macromolecular rapid communications.
container_volume 28
creator Borodina, Tatiana
Markvicheva, Elena
Kunizhev, Stanislav
Möhwald, Helmuth
Sukhorukov, Gleb B.
Kreft, Oliver
description Self‐disintegrating microcapsules were prepared by encapsulating a highly active mix of proteases (Pronase®) into biodegradable polyelectrolyte shells. Pronase was captured by micron‐sized calcium carbonate particles that were subsequently embedded into onion‐like shells of poly(L‐arginine) and poly(L‐aspartic acid). EDTA treatment was used to extract the calcium carbonate constituents from the resulting core‐shell particles. As a consequence, Pronase was released into the capsule interior and started to digest the surrounding polyelectrolyte shell. Lifetimes of such self‐disintegrating capsules could be successfully adjusted to seconds, hours or days by varying the amount of encapsulated Pronase. The enzyme‐mediated, sustained release of encapsulated DNA is presented as a prospective application in drug delivery.
doi_str_mv 10.1002/marc.200700409
format Article
fullrecord <record><control><sourceid>proquest_cross</sourceid><recordid>TN_cdi_proquest_miscellaneous_30102087</recordid><sourceformat>XML</sourceformat><sourcesystem>PC</sourcesystem><sourcerecordid>30102087</sourcerecordid><originalsourceid>FETCH-LOGICAL-c4249-4f09b78a171b182504ddb06ab1df5713577e1350e2ca6828c2e770cd7571554b3</originalsourceid><addsrcrecordid>eNqFkMFPwjAUhxujiYhePe_kbfjarusWT2QoGgEJYDw23fZGpoVhC1H-e0tmiDcvfU3e73t57yPkmkKPArDblbZFjwFIgAjSE9KhgtGQp0ye-j8wFlLO43Ny4dw7ACQRsA65y5r11jbGYBnM0KB2GDRVMJj0g8o2q2COpgoHuLS6rNfLYFwXtin0xu0MuktyVmnj8Oq3dsnrw_0iewxHL8OnrD8Ki4hFaRhVkOYy0VTSnCZMQFSWOcQ6p2UlJOVCSvQvICt0nLCkYCglFKX0TSGinHfJTTt3Y5vPHbqtWtWuQGP0GpudUxz8dZBIH-y1Qb-kcxYrtbG117JXFNTBkTo4UkdHHkhb4Ks2uP8nrcb9WfaXDVu2dlv8PrLafqhYcinU22SoplNBYZ49qwX_AeePeBo</addsrcrecordid><sourcetype>Aggregation Database</sourcetype><iscdi>true</iscdi><recordtype>article</recordtype><pqid>30102087</pqid></control><display><type>article</type><title>Controlled Release of DNA from Self-Degrading Microcapsules</title><source>Wiley-Blackwell Journals</source><creator>Borodina, Tatiana ; Markvicheva, Elena ; Kunizhev, Stanislav ; Möhwald, Helmuth ; Sukhorukov, Gleb B. ; Kreft, Oliver</creator><creatorcontrib>Borodina, Tatiana ; Markvicheva, Elena ; Kunizhev, Stanislav ; Möhwald, Helmuth ; Sukhorukov, Gleb B. ; Kreft, Oliver</creatorcontrib><description>Self‐disintegrating microcapsules were prepared by encapsulating a highly active mix of proteases (Pronase®) into biodegradable polyelectrolyte shells. Pronase was captured by micron‐sized calcium carbonate particles that were subsequently embedded into onion‐like shells of poly(L‐arginine) and poly(L‐aspartic acid). EDTA treatment was used to extract the calcium carbonate constituents from the resulting core‐shell particles. As a consequence, Pronase was released into the capsule interior and started to digest the surrounding polyelectrolyte shell. Lifetimes of such self‐disintegrating capsules could be successfully adjusted to seconds, hours or days by varying the amount of encapsulated Pronase. The enzyme‐mediated, sustained release of encapsulated DNA is presented as a prospective application in drug delivery.</description><identifier>ISSN: 1022-1336</identifier><identifier>EISSN: 1521-3927</identifier><identifier>DOI: 10.1002/marc.200700409</identifier><language>eng</language><publisher>Weinheim: WILEY-VCH Verlag</publisher><subject>biodegradable polymers ; DNA ; drug delivery systems ; enzymes ; microencapsulation</subject><ispartof>Macromolecular rapid communications., 2007-09, Vol.28 (18-19), p.1894-1899</ispartof><rights>Copyright © 2007 WILEY‐VCH Verlag GmbH &amp; Co. KGaA, Weinheim</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c4249-4f09b78a171b182504ddb06ab1df5713577e1350e2ca6828c2e770cd7571554b3</citedby><cites>FETCH-LOGICAL-c4249-4f09b78a171b182504ddb06ab1df5713577e1350e2ca6828c2e770cd7571554b3</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://onlinelibrary.wiley.com/doi/pdf/10.1002%2Fmarc.200700409$$EPDF$$P50$$Gwiley$$H</linktopdf><linktohtml>$$Uhttps://onlinelibrary.wiley.com/doi/full/10.1002%2Fmarc.200700409$$EHTML$$P50$$Gwiley$$H</linktohtml><link.rule.ids>314,780,784,1417,27924,27925,45574,45575</link.rule.ids></links><search><creatorcontrib>Borodina, Tatiana</creatorcontrib><creatorcontrib>Markvicheva, Elena</creatorcontrib><creatorcontrib>Kunizhev, Stanislav</creatorcontrib><creatorcontrib>Möhwald, Helmuth</creatorcontrib><creatorcontrib>Sukhorukov, Gleb B.</creatorcontrib><creatorcontrib>Kreft, Oliver</creatorcontrib><title>Controlled Release of DNA from Self-Degrading Microcapsules</title><title>Macromolecular rapid communications.</title><addtitle>Macromol. Rapid Commun</addtitle><description>Self‐disintegrating microcapsules were prepared by encapsulating a highly active mix of proteases (Pronase®) into biodegradable polyelectrolyte shells. Pronase was captured by micron‐sized calcium carbonate particles that were subsequently embedded into onion‐like shells of poly(L‐arginine) and poly(L‐aspartic acid). EDTA treatment was used to extract the calcium carbonate constituents from the resulting core‐shell particles. As a consequence, Pronase was released into the capsule interior and started to digest the surrounding polyelectrolyte shell. Lifetimes of such self‐disintegrating capsules could be successfully adjusted to seconds, hours or days by varying the amount of encapsulated Pronase. The enzyme‐mediated, sustained release of encapsulated DNA is presented as a prospective application in drug delivery.</description><subject>biodegradable polymers</subject><subject>DNA</subject><subject>drug delivery systems</subject><subject>enzymes</subject><subject>microencapsulation</subject><issn>1022-1336</issn><issn>1521-3927</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2007</creationdate><recordtype>article</recordtype><recordid>eNqFkMFPwjAUhxujiYhePe_kbfjarusWT2QoGgEJYDw23fZGpoVhC1H-e0tmiDcvfU3e73t57yPkmkKPArDblbZFjwFIgAjSE9KhgtGQp0ye-j8wFlLO43Ny4dw7ACQRsA65y5r11jbGYBnM0KB2GDRVMJj0g8o2q2COpgoHuLS6rNfLYFwXtin0xu0MuktyVmnj8Oq3dsnrw_0iewxHL8OnrD8Ki4hFaRhVkOYy0VTSnCZMQFSWOcQ6p2UlJOVCSvQvICt0nLCkYCglFKX0TSGinHfJTTt3Y5vPHbqtWtWuQGP0GpudUxz8dZBIH-y1Qb-kcxYrtbG117JXFNTBkTo4UkdHHkhb4Ks2uP8nrcb9WfaXDVu2dlv8PrLafqhYcinU22SoplNBYZ49qwX_AeePeBo</recordid><startdate>20070918</startdate><enddate>20070918</enddate><creator>Borodina, Tatiana</creator><creator>Markvicheva, Elena</creator><creator>Kunizhev, Stanislav</creator><creator>Möhwald, Helmuth</creator><creator>Sukhorukov, Gleb B.</creator><creator>Kreft, Oliver</creator><general>WILEY-VCH Verlag</general><general>WILEY‐VCH Verlag</general><scope>BSCLL</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7SR</scope><scope>7U5</scope><scope>8FD</scope><scope>JG9</scope><scope>L7M</scope></search><sort><creationdate>20070918</creationdate><title>Controlled Release of DNA from Self-Degrading Microcapsules</title><author>Borodina, Tatiana ; Markvicheva, Elena ; Kunizhev, Stanislav ; Möhwald, Helmuth ; Sukhorukov, Gleb B. ; Kreft, Oliver</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c4249-4f09b78a171b182504ddb06ab1df5713577e1350e2ca6828c2e770cd7571554b3</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2007</creationdate><topic>biodegradable polymers</topic><topic>DNA</topic><topic>drug delivery systems</topic><topic>enzymes</topic><topic>microencapsulation</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Borodina, Tatiana</creatorcontrib><creatorcontrib>Markvicheva, Elena</creatorcontrib><creatorcontrib>Kunizhev, Stanislav</creatorcontrib><creatorcontrib>Möhwald, Helmuth</creatorcontrib><creatorcontrib>Sukhorukov, Gleb B.</creatorcontrib><creatorcontrib>Kreft, Oliver</creatorcontrib><collection>Istex</collection><collection>CrossRef</collection><collection>Engineered Materials Abstracts</collection><collection>Solid State and Superconductivity Abstracts</collection><collection>Technology Research Database</collection><collection>Materials Research Database</collection><collection>Advanced Technologies Database with Aerospace</collection><jtitle>Macromolecular rapid communications.</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Borodina, Tatiana</au><au>Markvicheva, Elena</au><au>Kunizhev, Stanislav</au><au>Möhwald, Helmuth</au><au>Sukhorukov, Gleb B.</au><au>Kreft, Oliver</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Controlled Release of DNA from Self-Degrading Microcapsules</atitle><jtitle>Macromolecular rapid communications.</jtitle><addtitle>Macromol. Rapid Commun</addtitle><date>2007-09-18</date><risdate>2007</risdate><volume>28</volume><issue>18-19</issue><spage>1894</spage><epage>1899</epage><pages>1894-1899</pages><issn>1022-1336</issn><eissn>1521-3927</eissn><abstract>Self‐disintegrating microcapsules were prepared by encapsulating a highly active mix of proteases (Pronase®) into biodegradable polyelectrolyte shells. Pronase was captured by micron‐sized calcium carbonate particles that were subsequently embedded into onion‐like shells of poly(L‐arginine) and poly(L‐aspartic acid). EDTA treatment was used to extract the calcium carbonate constituents from the resulting core‐shell particles. As a consequence, Pronase was released into the capsule interior and started to digest the surrounding polyelectrolyte shell. Lifetimes of such self‐disintegrating capsules could be successfully adjusted to seconds, hours or days by varying the amount of encapsulated Pronase. The enzyme‐mediated, sustained release of encapsulated DNA is presented as a prospective application in drug delivery.</abstract><cop>Weinheim</cop><pub>WILEY-VCH Verlag</pub><doi>10.1002/marc.200700409</doi><tpages>6</tpages></addata></record>
fulltext fulltext
identifier ISSN: 1022-1336
ispartof Macromolecular rapid communications., 2007-09, Vol.28 (18-19), p.1894-1899
issn 1022-1336
1521-3927
language eng
recordid cdi_proquest_miscellaneous_30102087
source Wiley-Blackwell Journals
subjects biodegradable polymers
DNA
drug delivery systems
enzymes
microencapsulation
title Controlled Release of DNA from Self-Degrading Microcapsules
url https://sfx.bib-bvb.de/sfx_tum?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&ctx_tim=2025-01-07T15%3A24%3A16IST&url_ver=Z39.88-2004&url_ctx_fmt=infofi/fmt:kev:mtx:ctx&rfr_id=info:sid/primo.exlibrisgroup.com:primo3-Article-proquest_cross&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.atitle=Controlled%20Release%20of%20DNA%20from%20Self-Degrading%20Microcapsules&rft.jtitle=Macromolecular%20rapid%20communications.&rft.au=Borodina,%20Tatiana&rft.date=2007-09-18&rft.volume=28&rft.issue=18-19&rft.spage=1894&rft.epage=1899&rft.pages=1894-1899&rft.issn=1022-1336&rft.eissn=1521-3927&rft_id=info:doi/10.1002/marc.200700409&rft_dat=%3Cproquest_cross%3E30102087%3C/proquest_cross%3E%3Curl%3E%3C/url%3E&disable_directlink=true&sfx.directlink=off&sfx.report_link=0&rft_id=info:oai/&rft_pqid=30102087&rft_id=info:pmid/&rfr_iscdi=true