Oxidation of a Phospholipid at an Electrode Modified with an Electrochemically Formed Sol-Gel Film Doped with Cyclodextrin
In aqueous, un‐buffered solution at a potential where H+ is generated in a tetraethylorthosilicate sol, nm‐scale deposits of silica on electrodes are formed. Inclusion of β‐cyclodextrin in the sol promotes electrochemical activity, presumably by producing channels in the otherwise‐passivating film....
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Veröffentlicht in: | Electroanalysis (New York, N.Y.) N.Y.), 2007-01, Vol.19 (2-3), p.139-143 |
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container_title | Electroanalysis (New York, N.Y.) |
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creator | Wandstrat, Michelle M. Spendel, Wolfgang U. Pacey, Gilbert E. Cox, James A. |
description | In aqueous, un‐buffered solution at a potential where H+ is generated in a tetraethylorthosilicate sol, nm‐scale deposits of silica on electrodes are formed. Inclusion of β‐cyclodextrin in the sol promotes electrochemical activity, presumably by producing channels in the otherwise‐passivating film. With the additional provision of inclusion of a redox mediator, RhII, the electrochemical oxidation of a representative phospholipid (PL), phosphatidylcholine (PC), is demonstrated; the process occurs without the passivation that otherwise precludes the voltammetric determination of PLs. By cyclic voltammetry, current proportional to PC concentration in the range 1–100 μM is achieved with the described electrode. |
doi_str_mv | 10.1002/elan.200603678 |
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Inclusion of β‐cyclodextrin in the sol promotes electrochemical activity, presumably by producing channels in the otherwise‐passivating film. With the additional provision of inclusion of a redox mediator, RhII, the electrochemical oxidation of a representative phospholipid (PL), phosphatidylcholine (PC), is demonstrated; the process occurs without the passivation that otherwise precludes the voltammetric determination of PLs. By cyclic voltammetry, current proportional to PC concentration in the range 1–100 μM is achieved with the described electrode.</description><identifier>ISSN: 1040-0397</identifier><identifier>EISSN: 1521-4109</identifier><identifier>DOI: 10.1002/elan.200603678</identifier><language>eng</language><publisher>Weinheim: WILEY-VCH Verlag</publisher><subject>Cyclodextrin ; Electrochemical oxidation ; Phospholipid ; Pores ; Silica-coated electrode ; Sol-gel</subject><ispartof>Electroanalysis (New York, N.Y.), 2007-01, Vol.19 (2-3), p.139-143</ispartof><rights>Copyright © 2007 WILEY‐VCH Verlag GmbH & Co. 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Inclusion of β‐cyclodextrin in the sol promotes electrochemical activity, presumably by producing channels in the otherwise‐passivating film. With the additional provision of inclusion of a redox mediator, RhII, the electrochemical oxidation of a representative phospholipid (PL), phosphatidylcholine (PC), is demonstrated; the process occurs without the passivation that otherwise precludes the voltammetric determination of PLs. By cyclic voltammetry, current proportional to PC concentration in the range 1–100 μM is achieved with the described electrode.</description><subject>Cyclodextrin</subject><subject>Electrochemical oxidation</subject><subject>Phospholipid</subject><subject>Pores</subject><subject>Silica-coated electrode</subject><subject>Sol-gel</subject><issn>1040-0397</issn><issn>1521-4109</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2007</creationdate><recordtype>article</recordtype><recordid>eNqFkD1v2zAQQIWiAeImWTNz6ibnaEqiOKb-agDlA0ibjARFnWC2lKmSMmz314eBEyNbJh7A9w64lySXFMYUYHKFVq3HE4ACWMHLL8mI5hOaZhTE1zhDBikwwU-TbyH8AQBRZGKU_L_fmUYNxq2Ja4kiDysX-pWzpjcNUQNRazK3qAfvGiS3rjGtwYZszbD68KVX2BmtrN2ThfNdBB6dTZdoycLYjsxc_-5M99rGTbvBm_V5ctIqG_Di7T1Lfi_mv6Y_0-p-eTO9rlLN8rJMi0IzEByztilLpTjUoimAtxQ0z5HWZVbWWuhWCFrX8WSR1QW2PN7NIlMjO0u-H_b23v3bYBhkZ4JGG3Oh2wTJYrJJlosIjg-g9i4Ej63svemU30sK8jWxfE0sj4mjIA7C1ljcf0LLeXV999FND64JA-6OrvJ_ZcEZz-Xz3VLOfiyenqtqJjP2ApymkJo</recordid><startdate>200701</startdate><enddate>200701</enddate><creator>Wandstrat, Michelle M.</creator><creator>Spendel, Wolfgang U.</creator><creator>Pacey, Gilbert E.</creator><creator>Cox, James A.</creator><general>WILEY-VCH Verlag</general><general>WILEY‐VCH Verlag</general><scope>BSCLL</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7U5</scope><scope>8FD</scope><scope>L7M</scope></search><sort><creationdate>200701</creationdate><title>Oxidation of a Phospholipid at an Electrode Modified with an Electrochemically Formed Sol-Gel Film Doped with Cyclodextrin</title><author>Wandstrat, Michelle M. ; Spendel, Wolfgang U. ; Pacey, Gilbert E. ; Cox, James A.</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c3588-66c3097e4fd88aa70b9d607f10c75e1b848bc9cf991bb15294b6ef74103f10be3</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2007</creationdate><topic>Cyclodextrin</topic><topic>Electrochemical oxidation</topic><topic>Phospholipid</topic><topic>Pores</topic><topic>Silica-coated electrode</topic><topic>Sol-gel</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Wandstrat, Michelle M.</creatorcontrib><creatorcontrib>Spendel, Wolfgang U.</creatorcontrib><creatorcontrib>Pacey, Gilbert E.</creatorcontrib><creatorcontrib>Cox, James A.</creatorcontrib><collection>Istex</collection><collection>CrossRef</collection><collection>Solid State and Superconductivity Abstracts</collection><collection>Technology Research Database</collection><collection>Advanced Technologies Database with Aerospace</collection><jtitle>Electroanalysis (New York, N.Y.)</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Wandstrat, Michelle M.</au><au>Spendel, Wolfgang U.</au><au>Pacey, Gilbert E.</au><au>Cox, James A.</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Oxidation of a Phospholipid at an Electrode Modified with an Electrochemically Formed Sol-Gel Film Doped with Cyclodextrin</atitle><jtitle>Electroanalysis (New York, N.Y.)</jtitle><addtitle>Electroanalysis</addtitle><date>2007-01</date><risdate>2007</risdate><volume>19</volume><issue>2-3</issue><spage>139</spage><epage>143</epage><pages>139-143</pages><issn>1040-0397</issn><eissn>1521-4109</eissn><abstract>In aqueous, un‐buffered solution at a potential where H+ is generated in a tetraethylorthosilicate sol, nm‐scale deposits of silica on electrodes are formed. Inclusion of β‐cyclodextrin in the sol promotes electrochemical activity, presumably by producing channels in the otherwise‐passivating film. With the additional provision of inclusion of a redox mediator, RhII, the electrochemical oxidation of a representative phospholipid (PL), phosphatidylcholine (PC), is demonstrated; the process occurs without the passivation that otherwise precludes the voltammetric determination of PLs. By cyclic voltammetry, current proportional to PC concentration in the range 1–100 μM is achieved with the described electrode.</abstract><cop>Weinheim</cop><pub>WILEY-VCH Verlag</pub><doi>10.1002/elan.200603678</doi><tpages>5</tpages></addata></record> |
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source | Wiley Online Library Journals Frontfile Complete |
subjects | Cyclodextrin Electrochemical oxidation Phospholipid Pores Silica-coated electrode Sol-gel |
title | Oxidation of a Phospholipid at an Electrode Modified with an Electrochemically Formed Sol-Gel Film Doped with Cyclodextrin |
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