A run-to-run framework for prandial insulin dosing: handling real-life uncertainty
Individuals with type 1 diabetes require frequent adjustment of their insulin dose to maintain as near to normal glycaemia as possible. This process is not only burdensome but also, for many, difficult to achieve. As a result, control algorithms to facilitate insulin dosage have been proposed, but h...
Gespeichert in:
| Veröffentlicht in: | International journal of robust and nonlinear control 2007-09, Vol.17 (13), p.1194-1213 |
|---|---|
| Hauptverfasser: | , , , |
| Format: | Artikel |
| Sprache: | eng |
| Schlagworte: | |
| Online-Zugang: | Volltext |
| Tags: |
Tag hinzufügen
Keine Tags, Fügen Sie den ersten Tag hinzu!
|
| container_end_page | 1213 |
|---|---|
| container_issue | 13 |
| container_start_page | 1194 |
| container_title | International journal of robust and nonlinear control |
| container_volume | 17 |
| creator | Palerm, C. C. Zisser, H. Jovanovič, L. Doyle III, F. J. |
| description | Individuals with type 1 diabetes require frequent adjustment of their insulin dose to maintain as near to normal glycaemia as possible. This process is not only burdensome but also, for many, difficult to achieve. As a result, control algorithms to facilitate insulin dosage have been proposed, but have not been completely successful in normalizing glycaemia. Here we present a novel run‐to‐run control algorithm to adjust the meal‐related insulin dose using only post‐prandial blood glucose measurements. For each meal independently, the insulin dose is adjusted based on the performance measure for the same meal the previous day. A robustness analysis is performed which considers the sources of uncertainty typically encountered in clinical use. This shows that the system remains stable even with large uncertainty. Copyright © 2006 John Wiley & Sons, Ltd. |
| doi_str_mv | 10.1002/rnc.1103 |
| format | Article |
| fullrecord | <record><control><sourceid>proquest_cross</sourceid><recordid>TN_cdi_proquest_miscellaneous_30059747</recordid><sourceformat>XML</sourceformat><sourcesystem>PC</sourcesystem><sourcerecordid>30059747</sourcerecordid><originalsourceid>FETCH-LOGICAL-c3343-c69dc4c079beff80a0dbdd1d699d8c6135e0205cdf1b993b807a067e50acc5a03</originalsourceid><addsrcrecordid>eNp10E1LwzAYB_AgCs4p-BFyEi-ZT5q2WbzJ0CmMiUOnt5Am6Yzr0pm0zH17OyaCB0_P24_n8EfonMKAAiRXwesBpcAOUI-CEIQmTBzu-lSQoUjYMTqJ8QOguyVpD81ucGg9aWrSFVwGtbKbOixxWQe8DsobpyrsfGwr57Gpo_OLa_ze7bt5gYNVFalcaXHrtQ2Ncr7ZnqKjUlXRnv3UPnq5u30e3ZPJ4_hhdDMhmrGUEZ0Lo1MNXBS2LIegwBTGUJMLYYY6pyyzkECmTUkLIVgxBK4g5zYDpXWmgPXRxf7vOtSfrY2NXLmobVUpb-s2SgaQCZ7yDl7uoQ51jMGWch3cSoWtpCB3ockuNLkLraNkTzeustt_nZxNR3-9i439-vUqLGXOGc_k63Qs50850DcOcs6-AQekfZM</addsrcrecordid><sourcetype>Aggregation Database</sourcetype><iscdi>true</iscdi><recordtype>article</recordtype><pqid>30059747</pqid></control><display><type>article</type><title>A run-to-run framework for prandial insulin dosing: handling real-life uncertainty</title><source>Wiley Online Library All Journals</source><creator>Palerm, C. C. ; Zisser, H. ; Jovanovič, L. ; Doyle III, F. J.</creator><creatorcontrib>Palerm, C. C. ; Zisser, H. ; Jovanovič, L. ; Doyle III, F. J.</creatorcontrib><description>Individuals with type 1 diabetes require frequent adjustment of their insulin dose to maintain as near to normal glycaemia as possible. This process is not only burdensome but also, for many, difficult to achieve. As a result, control algorithms to facilitate insulin dosage have been proposed, but have not been completely successful in normalizing glycaemia. Here we present a novel run‐to‐run control algorithm to adjust the meal‐related insulin dose using only post‐prandial blood glucose measurements. For each meal independently, the insulin dose is adjusted based on the performance measure for the same meal the previous day. A robustness analysis is performed which considers the sources of uncertainty typically encountered in clinical use. This shows that the system remains stable even with large uncertainty. Copyright © 2006 John Wiley & Sons, Ltd.</description><identifier>ISSN: 1049-8923</identifier><identifier>EISSN: 1099-1239</identifier><identifier>DOI: 10.1002/rnc.1103</identifier><language>eng</language><publisher>Chichester, UK: John Wiley & Sons, Ltd</publisher><subject>biomedical control ; insulin dosing ; robustness ; run-to-run control ; type 1 diabetes</subject><ispartof>International journal of robust and nonlinear control, 2007-09, Vol.17 (13), p.1194-1213</ispartof><rights>Copyright © 2006 John Wiley & Sons, Ltd.</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c3343-c69dc4c079beff80a0dbdd1d699d8c6135e0205cdf1b993b807a067e50acc5a03</citedby><cites>FETCH-LOGICAL-c3343-c69dc4c079beff80a0dbdd1d699d8c6135e0205cdf1b993b807a067e50acc5a03</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://onlinelibrary.wiley.com/doi/pdf/10.1002%2Frnc.1103$$EPDF$$P50$$Gwiley$$H</linktopdf><linktohtml>$$Uhttps://onlinelibrary.wiley.com/doi/full/10.1002%2Frnc.1103$$EHTML$$P50$$Gwiley$$H</linktohtml><link.rule.ids>314,780,784,1416,27922,27923,45572,45573</link.rule.ids></links><search><creatorcontrib>Palerm, C. C.</creatorcontrib><creatorcontrib>Zisser, H.</creatorcontrib><creatorcontrib>Jovanovič, L.</creatorcontrib><creatorcontrib>Doyle III, F. J.</creatorcontrib><title>A run-to-run framework for prandial insulin dosing: handling real-life uncertainty</title><title>International journal of robust and nonlinear control</title><addtitle>Int. J. Robust Nonlinear Control</addtitle><description>Individuals with type 1 diabetes require frequent adjustment of their insulin dose to maintain as near to normal glycaemia as possible. This process is not only burdensome but also, for many, difficult to achieve. As a result, control algorithms to facilitate insulin dosage have been proposed, but have not been completely successful in normalizing glycaemia. Here we present a novel run‐to‐run control algorithm to adjust the meal‐related insulin dose using only post‐prandial blood glucose measurements. For each meal independently, the insulin dose is adjusted based on the performance measure for the same meal the previous day. A robustness analysis is performed which considers the sources of uncertainty typically encountered in clinical use. This shows that the system remains stable even with large uncertainty. Copyright © 2006 John Wiley & Sons, Ltd.</description><subject>biomedical control</subject><subject>insulin dosing</subject><subject>robustness</subject><subject>run-to-run control</subject><subject>type 1 diabetes</subject><issn>1049-8923</issn><issn>1099-1239</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2007</creationdate><recordtype>article</recordtype><recordid>eNp10E1LwzAYB_AgCs4p-BFyEi-ZT5q2WbzJ0CmMiUOnt5Am6Yzr0pm0zH17OyaCB0_P24_n8EfonMKAAiRXwesBpcAOUI-CEIQmTBzu-lSQoUjYMTqJ8QOguyVpD81ucGg9aWrSFVwGtbKbOixxWQe8DsobpyrsfGwr57Gpo_OLa_ze7bt5gYNVFalcaXHrtQ2Ncr7ZnqKjUlXRnv3UPnq5u30e3ZPJ4_hhdDMhmrGUEZ0Lo1MNXBS2LIegwBTGUJMLYYY6pyyzkECmTUkLIVgxBK4g5zYDpXWmgPXRxf7vOtSfrY2NXLmobVUpb-s2SgaQCZ7yDl7uoQ51jMGWch3cSoWtpCB3ockuNLkLraNkTzeustt_nZxNR3-9i439-vUqLGXOGc_k63Qs50850DcOcs6-AQekfZM</recordid><startdate>20070910</startdate><enddate>20070910</enddate><creator>Palerm, C. C.</creator><creator>Zisser, H.</creator><creator>Jovanovič, L.</creator><creator>Doyle III, F. J.</creator><general>John Wiley & Sons, Ltd</general><scope>BSCLL</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7SC</scope><scope>7SP</scope><scope>7TB</scope><scope>8FD</scope><scope>FR3</scope><scope>JQ2</scope><scope>L7M</scope><scope>L~C</scope><scope>L~D</scope></search><sort><creationdate>20070910</creationdate><title>A run-to-run framework for prandial insulin dosing: handling real-life uncertainty</title><author>Palerm, C. C. ; Zisser, H. ; Jovanovič, L. ; Doyle III, F. J.</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c3343-c69dc4c079beff80a0dbdd1d699d8c6135e0205cdf1b993b807a067e50acc5a03</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2007</creationdate><topic>biomedical control</topic><topic>insulin dosing</topic><topic>robustness</topic><topic>run-to-run control</topic><topic>type 1 diabetes</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Palerm, C. C.</creatorcontrib><creatorcontrib>Zisser, H.</creatorcontrib><creatorcontrib>Jovanovič, L.</creatorcontrib><creatorcontrib>Doyle III, F. J.</creatorcontrib><collection>Istex</collection><collection>CrossRef</collection><collection>Computer and Information Systems Abstracts</collection><collection>Electronics & Communications Abstracts</collection><collection>Mechanical & Transportation Engineering Abstracts</collection><collection>Technology Research Database</collection><collection>Engineering Research Database</collection><collection>ProQuest Computer Science Collection</collection><collection>Advanced Technologies Database with Aerospace</collection><collection>Computer and Information Systems Abstracts Academic</collection><collection>Computer and Information Systems Abstracts Professional</collection><jtitle>International journal of robust and nonlinear control</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Palerm, C. C.</au><au>Zisser, H.</au><au>Jovanovič, L.</au><au>Doyle III, F. J.</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>A run-to-run framework for prandial insulin dosing: handling real-life uncertainty</atitle><jtitle>International journal of robust and nonlinear control</jtitle><addtitle>Int. J. Robust Nonlinear Control</addtitle><date>2007-09-10</date><risdate>2007</risdate><volume>17</volume><issue>13</issue><spage>1194</spage><epage>1213</epage><pages>1194-1213</pages><issn>1049-8923</issn><eissn>1099-1239</eissn><abstract>Individuals with type 1 diabetes require frequent adjustment of their insulin dose to maintain as near to normal glycaemia as possible. This process is not only burdensome but also, for many, difficult to achieve. As a result, control algorithms to facilitate insulin dosage have been proposed, but have not been completely successful in normalizing glycaemia. Here we present a novel run‐to‐run control algorithm to adjust the meal‐related insulin dose using only post‐prandial blood glucose measurements. For each meal independently, the insulin dose is adjusted based on the performance measure for the same meal the previous day. A robustness analysis is performed which considers the sources of uncertainty typically encountered in clinical use. This shows that the system remains stable even with large uncertainty. Copyright © 2006 John Wiley & Sons, Ltd.</abstract><cop>Chichester, UK</cop><pub>John Wiley & Sons, Ltd</pub><doi>10.1002/rnc.1103</doi><tpages>20</tpages></addata></record> |
| fulltext | fulltext |
| identifier | ISSN: 1049-8923 |
| ispartof | International journal of robust and nonlinear control, 2007-09, Vol.17 (13), p.1194-1213 |
| issn | 1049-8923 1099-1239 |
| language | eng |
| recordid | cdi_proquest_miscellaneous_30059747 |
| source | Wiley Online Library All Journals |
| subjects | biomedical control insulin dosing robustness run-to-run control type 1 diabetes |
| title | A run-to-run framework for prandial insulin dosing: handling real-life uncertainty |
| url | https://sfx.bib-bvb.de/sfx_tum?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&ctx_tim=2025-01-14T12%3A42%3A01IST&url_ver=Z39.88-2004&url_ctx_fmt=infofi/fmt:kev:mtx:ctx&rfr_id=info:sid/primo.exlibrisgroup.com:primo3-Article-proquest_cross&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.atitle=A%20run-to-run%20framework%20for%20prandial%20insulin%20dosing:%20handling%20real-life%20uncertainty&rft.jtitle=International%20journal%20of%20robust%20and%20nonlinear%20control&rft.au=Palerm,%20C.%20C.&rft.date=2007-09-10&rft.volume=17&rft.issue=13&rft.spage=1194&rft.epage=1213&rft.pages=1194-1213&rft.issn=1049-8923&rft.eissn=1099-1239&rft_id=info:doi/10.1002/rnc.1103&rft_dat=%3Cproquest_cross%3E30059747%3C/proquest_cross%3E%3Curl%3E%3C/url%3E&disable_directlink=true&sfx.directlink=off&sfx.report_link=0&rft_id=info:oai/&rft_pqid=30059747&rft_id=info:pmid/&rfr_iscdi=true |