Nitrilase-Catalyzed Enantioselective Synthesis of Pyrrolidine- and Piperidinecarboxylic Acids

The enantioselective synthesis of the non‐proteinogenic amino acids β‐proline and nipecotic acids from their readily available nitriles is achieved in high enantiomeric excess by commercially available nitrilases. The presented procedure comprises not more than 4 steps, thus considerably reducing th...

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Veröffentlicht in:	Advanced synthesis & catalysis 2007-06, Vol.349 (8-9), p.1475-1480
Hauptverfasser:	Winkler, Margit, Meischler, Dorith, Klempier, Norbert
Format:	Artikel
Sprache:	eng
Schlagworte:	(iso)nipecotic acid biocatalysis enantioselective synthesis nitrilases pipecolic acid β-proline
Online-Zugang:	Volltext
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