Glioblastoma stem cell metabolism and immunity

Despite enormous efforts being invested in the development of novel therapies for brain malignancies, there remains a dire need for effective treatments, particularly for pediatric glioblastomas. Their poor prognosis has been attributed to the fact that conventional therapies target tumoral cells, b...

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Veröffentlicht in:Cancer and metastasis reviews 2024-09, Vol.43 (3), p.1015-1035
Hauptverfasser: Hawly, Joseph, Murcar, Micaela G., Schcolnik-Cabrera, Alejandro, Issa, Mark E.
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container_issue 3
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container_title Cancer and metastasis reviews
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creator Hawly, Joseph
Murcar, Micaela G.
Schcolnik-Cabrera, Alejandro
Issa, Mark E.
description Despite enormous efforts being invested in the development of novel therapies for brain malignancies, there remains a dire need for effective treatments, particularly for pediatric glioblastomas. Their poor prognosis has been attributed to the fact that conventional therapies target tumoral cells, but not glioblastoma stem cells (GSCs). GSCs are characterized by self-renewal, tumorigenicity, poor differentiation, and resistance to therapy. These characteristics represent the fundamental tools needed to recapitulate the tumor and result in a relapse. The mechanisms by which GSCs alter metabolic cues and escape elimination by immune cells are discussed in this article, along with potential strategies to harness effector immune cells against GSCs. As cellular immunotherapy is making significant advances in a variety of cancers, leveraging this underexplored reservoir may result in significant improvements in the treatment options for brain malignancies.
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subjects Biomedical and Life Sciences
Biomedicine
Brain tumors
Cancer Research
Cell differentiation
Cell self-renewal
Drug resistance
Effector cells
Glioblastoma
Glioma
Immune response
Immunotherapy
Metabolism
Oncology
Pediatrics
Review
Stem cells
Targeted cancer therapy
Tumor microenvironment
Tumorigenicity
title Glioblastoma stem cell metabolism and immunity
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