Suitability of Fourier transform infrared microscopy for the diagnosis of cystic echinococcosis in human tissue sections
Cystic echinococcosis (CE) is a global health concern caused by cestodes, posing diagnostic challenges due to nonspecific symptoms and inconclusive radiographic results. Diagnosis relies on histopathological evaluation of affected tissue, demanding comprehensive tools. In this retrospective case stu...
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| Veröffentlicht in: | Journal of biophotonics 2024-06, Vol.17 (6), p.e202300513-n/a |
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| creator | Brunner, A. Unterberger, S. H. Auer, H. Hautz, T. Schneeberger, S. Stalder, R. Badzoka, J. Kappacher, C. Huck, C. W. Zelger, B. Pallua, J. D. |
| description | Cystic echinococcosis (CE) is a global health concern caused by cestodes, posing diagnostic challenges due to nonspecific symptoms and inconclusive radiographic results. Diagnosis relies on histopathological evaluation of affected tissue, demanding comprehensive tools. In this retrospective case study, Fourier transform infrared microscopy was explored for detecting and identifying CE through biochemical changes in human tissue sections. Tissue samples from 11 confirmed CE patients were analyzed. Archived FFPE blocks were cut and stained, and then CE‐positive unstained sections were examined using Fourier transform infrared microscopy post‐deparaffinization. Results revealed the method's ability to distinguish echinococcus elements from human tissue, irrespective of organ type. This research showcases the potential of mid‐infrared microscopy as a valuable diagnostic tool for CE, offering promise in enhancing diagnostic precision in the face of the disease's complexities.
Cystic echinococcosis (CE) is a global health concern caused by cestodes. In this retrospective case study, Fourier transform infrared microscopy was explored for detecting and identifying CE through biochemical changes in human tissue sections. Results revealed the method's ability to distinguish echinococcus elements from human tissue, irrespective of organ type. This research showcases the potential of mid‐infrared microscopy as a valuable diagnostic tool for CE. |
| doi_str_mv | 10.1002/jbio.202300513 |
| format | Article |
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Cystic echinococcosis (CE) is a global health concern caused by cestodes. In this retrospective case study, Fourier transform infrared microscopy was explored for detecting and identifying CE through biochemical changes in human tissue sections. Results revealed the method's ability to distinguish echinococcus elements from human tissue, irrespective of organ type. This research showcases the potential of mid‐infrared microscopy as a valuable diagnostic tool for CE.</description><identifier>ISSN: 1864-063X</identifier><identifier>EISSN: 1864-0648</identifier><identifier>DOI: 10.1002/jbio.202300513</identifier><identifier>PMID: 38531615</identifier><language>eng</language><publisher>Weinheim: WILEY‐VCH Verlag GmbH & Co. KGaA</publisher><subject>Diagnosis ; Echinococcosis ; Fourier transform infrared (FTIR) microscopic imaging ; Fourier transforms ; Global health ; histology ; Human tissues ; Microscopy ; PCR ; Public health ; Signs and symptoms ; Tissues</subject><ispartof>Journal of biophotonics, 2024-06, Vol.17 (6), p.e202300513-n/a</ispartof><rights>2024 The Authors. published by Wiley‐VCH GmbH.</rights><rights>2024 The Authors. Journal of Biophotonics published by Wiley‐VCH GmbH.</rights><rights>2024. This article is published under http://creativecommons.org/licenses/by-nc-nd/4.0/ (the “License”). Notwithstanding the ProQuest Terms and Conditions, you may use this content in accordance with the terms of the License.</rights><lds50>peer_reviewed</lds50><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed><cites>FETCH-LOGICAL-c3683-58ce37e256c8132defa1832987cf8ab8e2f8f061e874354d72d48d132f632bf73</cites><orcidid>0000-0003-0203-213X</orcidid></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://onlinelibrary.wiley.com/doi/pdf/10.1002%2Fjbio.202300513$$EPDF$$P50$$Gwiley$$Hfree_for_read</linktopdf><linktohtml>$$Uhttps://onlinelibrary.wiley.com/doi/full/10.1002%2Fjbio.202300513$$EHTML$$P50$$Gwiley$$Hfree_for_read</linktohtml><link.rule.ids>314,780,784,1416,27915,27916,45565,45566</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/38531615$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Brunner, A.</creatorcontrib><creatorcontrib>Unterberger, S. H.</creatorcontrib><creatorcontrib>Auer, H.</creatorcontrib><creatorcontrib>Hautz, T.</creatorcontrib><creatorcontrib>Schneeberger, S.</creatorcontrib><creatorcontrib>Stalder, R.</creatorcontrib><creatorcontrib>Badzoka, J.</creatorcontrib><creatorcontrib>Kappacher, C.</creatorcontrib><creatorcontrib>Huck, C. W.</creatorcontrib><creatorcontrib>Zelger, B.</creatorcontrib><creatorcontrib>Pallua, J. D.</creatorcontrib><title>Suitability of Fourier transform infrared microscopy for the diagnosis of cystic echinococcosis in human tissue sections</title><title>Journal of biophotonics</title><addtitle>J Biophotonics</addtitle><description>Cystic echinococcosis (CE) is a global health concern caused by cestodes, posing diagnostic challenges due to nonspecific symptoms and inconclusive radiographic results. Diagnosis relies on histopathological evaluation of affected tissue, demanding comprehensive tools. In this retrospective case study, Fourier transform infrared microscopy was explored for detecting and identifying CE through biochemical changes in human tissue sections. Tissue samples from 11 confirmed CE patients were analyzed. Archived FFPE blocks were cut and stained, and then CE‐positive unstained sections were examined using Fourier transform infrared microscopy post‐deparaffinization. Results revealed the method's ability to distinguish echinococcus elements from human tissue, irrespective of organ type. This research showcases the potential of mid‐infrared microscopy as a valuable diagnostic tool for CE, offering promise in enhancing diagnostic precision in the face of the disease's complexities.
Cystic echinococcosis (CE) is a global health concern caused by cestodes. In this retrospective case study, Fourier transform infrared microscopy was explored for detecting and identifying CE through biochemical changes in human tissue sections. Results revealed the method's ability to distinguish echinococcus elements from human tissue, irrespective of organ type. This research showcases the potential of mid‐infrared microscopy as a valuable diagnostic tool for CE.</description><subject>Diagnosis</subject><subject>Echinococcosis</subject><subject>Fourier transform infrared (FTIR) microscopic imaging</subject><subject>Fourier transforms</subject><subject>Global health</subject><subject>histology</subject><subject>Human tissues</subject><subject>Microscopy</subject><subject>PCR</subject><subject>Public health</subject><subject>Signs and symptoms</subject><subject>Tissues</subject><issn>1864-063X</issn><issn>1864-0648</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2024</creationdate><recordtype>article</recordtype><sourceid>24P</sourceid><sourceid>WIN</sourceid><recordid>eNqFkU1v1DAQhi0Eou3ClSOyxIXLLv6IHffYVvRLlXoAJG6R44zZWSX21k5E8-_xsu1W4sLJI80zj6z3JeQDZyvOmPiyaTGuBBOSMcXlK3LMja6WTFfm9WGWP4_ISc4bxjSTSr4lR9IoyTVXx-Tx24SjbbHHcabR08s4JYREx2RD9jENFINPNkFHB3QpZhe3My0LOq6Bdmh_hZgx707dnEd0FNwaQ3TRub8LDHQ9DTbQEXOegGZwI8aQ35E33vYZ3j-9C_Lj8uv3i-vl3f3VzcXZ3dJJbeRSGQeyBqG0M1yKDrzlRopTUztvbGtAeOOZ5mDqSqqqq0VXma6QXkvR-louyOe9d5viwwR5bAbMDvreBohTbkpwspK1LtYF-fQPuilphPK7QmnNWa20KtRqT-3SyAl8s0042DQ3nDW7TppdJ82hk3Lw8Uk7tQN0B_y5hAKc7oHf2MP8H11ze35z_yL_A4LwmhE</recordid><startdate>202406</startdate><enddate>202406</enddate><creator>Brunner, A.</creator><creator>Unterberger, S. H.</creator><creator>Auer, H.</creator><creator>Hautz, T.</creator><creator>Schneeberger, S.</creator><creator>Stalder, R.</creator><creator>Badzoka, J.</creator><creator>Kappacher, C.</creator><creator>Huck, C. W.</creator><creator>Zelger, B.</creator><creator>Pallua, J. D.</creator><general>WILEY‐VCH Verlag GmbH & Co. KGaA</general><general>Wiley Subscription Services, Inc</general><scope>24P</scope><scope>WIN</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7QO</scope><scope>7SP</scope><scope>7SR</scope><scope>7U5</scope><scope>8FD</scope><scope>FR3</scope><scope>JG9</scope><scope>K9.</scope><scope>L7M</scope><scope>P64</scope><scope>7X8</scope><orcidid>https://orcid.org/0000-0003-0203-213X</orcidid></search><sort><creationdate>202406</creationdate><title>Suitability of Fourier transform infrared microscopy for the diagnosis of cystic echinococcosis in human tissue sections</title><author>Brunner, A. ; Unterberger, S. H. ; Auer, H. ; Hautz, T. ; Schneeberger, S. ; Stalder, R. ; Badzoka, J. ; Kappacher, C. ; Huck, C. W. ; Zelger, B. ; Pallua, J. D.</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c3683-58ce37e256c8132defa1832987cf8ab8e2f8f061e874354d72d48d132f632bf73</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2024</creationdate><topic>Diagnosis</topic><topic>Echinococcosis</topic><topic>Fourier transform infrared (FTIR) microscopic imaging</topic><topic>Fourier transforms</topic><topic>Global health</topic><topic>histology</topic><topic>Human tissues</topic><topic>Microscopy</topic><topic>PCR</topic><topic>Public health</topic><topic>Signs and symptoms</topic><topic>Tissues</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Brunner, A.</creatorcontrib><creatorcontrib>Unterberger, S. H.</creatorcontrib><creatorcontrib>Auer, H.</creatorcontrib><creatorcontrib>Hautz, T.</creatorcontrib><creatorcontrib>Schneeberger, S.</creatorcontrib><creatorcontrib>Stalder, R.</creatorcontrib><creatorcontrib>Badzoka, J.</creatorcontrib><creatorcontrib>Kappacher, C.</creatorcontrib><creatorcontrib>Huck, C. W.</creatorcontrib><creatorcontrib>Zelger, B.</creatorcontrib><creatorcontrib>Pallua, J. 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H.</au><au>Auer, H.</au><au>Hautz, T.</au><au>Schneeberger, S.</au><au>Stalder, R.</au><au>Badzoka, J.</au><au>Kappacher, C.</au><au>Huck, C. W.</au><au>Zelger, B.</au><au>Pallua, J. D.</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Suitability of Fourier transform infrared microscopy for the diagnosis of cystic echinococcosis in human tissue sections</atitle><jtitle>Journal of biophotonics</jtitle><addtitle>J Biophotonics</addtitle><date>2024-06</date><risdate>2024</risdate><volume>17</volume><issue>6</issue><spage>e202300513</spage><epage>n/a</epage><pages>e202300513-n/a</pages><issn>1864-063X</issn><eissn>1864-0648</eissn><abstract>Cystic echinococcosis (CE) is a global health concern caused by cestodes, posing diagnostic challenges due to nonspecific symptoms and inconclusive radiographic results. Diagnosis relies on histopathological evaluation of affected tissue, demanding comprehensive tools. 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Cystic echinococcosis (CE) is a global health concern caused by cestodes. In this retrospective case study, Fourier transform infrared microscopy was explored for detecting and identifying CE through biochemical changes in human tissue sections. Results revealed the method's ability to distinguish echinococcus elements from human tissue, irrespective of organ type. This research showcases the potential of mid‐infrared microscopy as a valuable diagnostic tool for CE.</abstract><cop>Weinheim</cop><pub>WILEY‐VCH Verlag GmbH & Co. KGaA</pub><pmid>38531615</pmid><doi>10.1002/jbio.202300513</doi><tpages>15</tpages><orcidid>https://orcid.org/0000-0003-0203-213X</orcidid><oa>free_for_read</oa></addata></record> |
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| subjects | Diagnosis Echinococcosis Fourier transform infrared (FTIR) microscopic imaging Fourier transforms Global health histology Human tissues Microscopy PCR Public health Signs and symptoms Tissues |
| title | Suitability of Fourier transform infrared microscopy for the diagnosis of cystic echinococcosis in human tissue sections |
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