Effects of drying process for amorphous waxy maize starch on theophylline release from starch-based tablets
Physical properties and theophylline‐release profiles of compressed tablets prepared with amorphous waxy maize starches dried using different methods were examined. A gelatinized waxy maize starch paste (10% solids in water) was either freeze‐dried or oven‐dried (40 or 105°C) until the moisture cont...
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| Veröffentlicht in: | Journal of applied polymer science 2007-08, Vol.105 (4), p.1908-1913 |
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| container_end_page | 1913 |
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| container_issue | 4 |
| container_start_page | 1908 |
| container_title | Journal of applied polymer science |
| container_volume | 105 |
| creator | Yoon, Hyun-Sung Kweon, Dong-Keon Lim, Seung-Taik |
| description | Physical properties and theophylline‐release profiles of compressed tablets prepared with amorphous waxy maize starches dried using different methods were examined. A gelatinized waxy maize starch paste (10% solids in water) was either freeze‐dried or oven‐dried (40 or 105°C) until the moisture content reached to |
| doi_str_mv | 10.1002/app.26239 |
| format | Article |
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A gelatinized waxy maize starch paste (10% solids in water) was either freeze‐dried or oven‐dried (40 or 105°C) until the moisture content reached to <5%. To form the tablets, the dried amorphous starch powders, either with or without theophylline (3 : 10, w/w), were remoistened to a water content of (17 ± 0.2)%, and compressed into tablets. The drying process applied to the amorphous starch powders affected both the compactness and swelling behavior of the tablets. Although no crystallinity was detected in all the starches tested, X‐ray diffraction patterns indicated that starch chains dried at the lower temperature (40°C) are allowed more time to re‐associate during the drying process than those dried at the higher temperature (105°C). The freeze‐dried starch powders formed tablets characterized by greater compactness and rigidity than was observed in the oven‐dried starch samples. The drug release of the tablets prepared with the starch dried at the higher temperature (105°C) occurred at a much slower rate than that of the tablets made with the starch dried at the lower temperature (40°C). The drug release characteristics of the freeze‐dried starch tablets were nearly identical to those of the tablets prepared with the starch dried at 105°C. © 2007 Wiley Periodicals, Inc. J Appl Polym Sci, 2007</description><identifier>ISSN: 0021-8995</identifier><identifier>EISSN: 1097-4628</identifier><identifier>DOI: 10.1002/app.26239</identifier><identifier>CODEN: JAPNAB</identifier><language>eng</language><publisher>Hoboken: Wiley Subscription Services, Inc., A Wiley Company</publisher><subject>amorphous ; Applied sciences ; Biological and medical sciences ; compression ; drug release ; Exact sciences and technology ; Forms of application and semi-finished materials ; General pharmacology ; Medical sciences ; Miscellaneous ; Pharmaceutical technology. Pharmaceutical industry ; Pharmacology. Drug treatments ; Polymer industry, paints, wood ; swelling ; Technology of polymers ; waxy maize starch</subject><ispartof>Journal of applied polymer science, 2007-08, Vol.105 (4), p.1908-1913</ispartof><rights>Copyright © 2007 Wiley Periodicals, Inc.</rights><rights>2008 INIST-CNRS</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c3689-f6537f969291406e9fd98df5ede44946d783a65362718ed3ba0d234e8e43f21f3</citedby><cites>FETCH-LOGICAL-c3689-f6537f969291406e9fd98df5ede44946d783a65362718ed3ba0d234e8e43f21f3</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://onlinelibrary.wiley.com/doi/pdf/10.1002%2Fapp.26239$$EPDF$$P50$$Gwiley$$H</linktopdf><linktohtml>$$Uhttps://onlinelibrary.wiley.com/doi/full/10.1002%2Fapp.26239$$EHTML$$P50$$Gwiley$$H</linktohtml><link.rule.ids>314,776,780,1411,27901,27902,45550,45551</link.rule.ids><backlink>$$Uhttp://pascal-francis.inist.fr/vibad/index.php?action=getRecordDetail&idt=18888250$$DView record in Pascal Francis$$Hfree_for_read</backlink></links><search><creatorcontrib>Yoon, Hyun-Sung</creatorcontrib><creatorcontrib>Kweon, Dong-Keon</creatorcontrib><creatorcontrib>Lim, Seung-Taik</creatorcontrib><title>Effects of drying process for amorphous waxy maize starch on theophylline release from starch-based tablets</title><title>Journal of applied polymer science</title><addtitle>J. Appl. Polym. Sci</addtitle><description>Physical properties and theophylline‐release profiles of compressed tablets prepared with amorphous waxy maize starches dried using different methods were examined. A gelatinized waxy maize starch paste (10% solids in water) was either freeze‐dried or oven‐dried (40 or 105°C) until the moisture content reached to <5%. To form the tablets, the dried amorphous starch powders, either with or without theophylline (3 : 10, w/w), were remoistened to a water content of (17 ± 0.2)%, and compressed into tablets. The drying process applied to the amorphous starch powders affected both the compactness and swelling behavior of the tablets. Although no crystallinity was detected in all the starches tested, X‐ray diffraction patterns indicated that starch chains dried at the lower temperature (40°C) are allowed more time to re‐associate during the drying process than those dried at the higher temperature (105°C). The freeze‐dried starch powders formed tablets characterized by greater compactness and rigidity than was observed in the oven‐dried starch samples. The drug release of the tablets prepared with the starch dried at the higher temperature (105°C) occurred at a much slower rate than that of the tablets made with the starch dried at the lower temperature (40°C). The drug release characteristics of the freeze‐dried starch tablets were nearly identical to those of the tablets prepared with the starch dried at 105°C. © 2007 Wiley Periodicals, Inc. J Appl Polym Sci, 2007</description><subject>amorphous</subject><subject>Applied sciences</subject><subject>Biological and medical sciences</subject><subject>compression</subject><subject>drug release</subject><subject>Exact sciences and technology</subject><subject>Forms of application and semi-finished materials</subject><subject>General pharmacology</subject><subject>Medical sciences</subject><subject>Miscellaneous</subject><subject>Pharmaceutical technology. Pharmaceutical industry</subject><subject>Pharmacology. Drug treatments</subject><subject>Polymer industry, paints, wood</subject><subject>swelling</subject><subject>Technology of polymers</subject><subject>waxy maize starch</subject><issn>0021-8995</issn><issn>1097-4628</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2007</creationdate><recordtype>article</recordtype><recordid>eNp1kM1P3DAQxS1UpG6hh_4HvrQSh4A_Esc-IkT5EII9tKrUi-VNxmyKEwdPEKR_PS67lBNzGWnm9570HiFfODvkjIkjN46HQglpdsiCM1MXpRL6A1nkHy-0MdVH8gnxD2OcV0wtyN2p99BMSKOnbZq74ZaOKTaASH1M1PUxjev4gPTRPc20d91foDi51KxpHOi0hjiu5xC6AWiCAA6B-hT7LVOs8qGlk1sFmHCf7HoXED5v9x75-f30x8l5cXVzdnFyfFU0UmlTeFXJ2htlhOElU2B8a3TrK2ihLE2p2lpLlxklaq6hlSvHWiFL0FBKL7iXe-TbxjcnuX8AnGzfYQMhuAFyFCuM0aXQOoMHG7BJETGBt2Pqepdmy5n9V6fNddqXOjP7dWvqsHHBJzc0Hb4JdB5RscwdbbjHLsD8vqE9Xi5fnYuNosMJnv4rXLqzqpZ1ZX9dn9nr5aVi5-K31fIZCdiUJQ</recordid><startdate>20070815</startdate><enddate>20070815</enddate><creator>Yoon, Hyun-Sung</creator><creator>Kweon, Dong-Keon</creator><creator>Lim, Seung-Taik</creator><general>Wiley Subscription Services, Inc., A Wiley Company</general><general>Wiley</general><scope>BSCLL</scope><scope>IQODW</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7SR</scope><scope>8FD</scope><scope>JG9</scope></search><sort><creationdate>20070815</creationdate><title>Effects of drying process for amorphous waxy maize starch on theophylline release from starch-based tablets</title><author>Yoon, Hyun-Sung ; Kweon, Dong-Keon ; Lim, Seung-Taik</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c3689-f6537f969291406e9fd98df5ede44946d783a65362718ed3ba0d234e8e43f21f3</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2007</creationdate><topic>amorphous</topic><topic>Applied sciences</topic><topic>Biological and medical sciences</topic><topic>compression</topic><topic>drug release</topic><topic>Exact sciences and technology</topic><topic>Forms of application and semi-finished materials</topic><topic>General pharmacology</topic><topic>Medical sciences</topic><topic>Miscellaneous</topic><topic>Pharmaceutical technology. Pharmaceutical industry</topic><topic>Pharmacology. Drug treatments</topic><topic>Polymer industry, paints, wood</topic><topic>swelling</topic><topic>Technology of polymers</topic><topic>waxy maize starch</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Yoon, Hyun-Sung</creatorcontrib><creatorcontrib>Kweon, Dong-Keon</creatorcontrib><creatorcontrib>Lim, Seung-Taik</creatorcontrib><collection>Istex</collection><collection>Pascal-Francis</collection><collection>CrossRef</collection><collection>Engineered Materials Abstracts</collection><collection>Technology Research Database</collection><collection>Materials Research Database</collection><jtitle>Journal of applied polymer science</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Yoon, Hyun-Sung</au><au>Kweon, Dong-Keon</au><au>Lim, Seung-Taik</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Effects of drying process for amorphous waxy maize starch on theophylline release from starch-based tablets</atitle><jtitle>Journal of applied polymer science</jtitle><addtitle>J. Appl. Polym. Sci</addtitle><date>2007-08-15</date><risdate>2007</risdate><volume>105</volume><issue>4</issue><spage>1908</spage><epage>1913</epage><pages>1908-1913</pages><issn>0021-8995</issn><eissn>1097-4628</eissn><coden>JAPNAB</coden><abstract>Physical properties and theophylline‐release profiles of compressed tablets prepared with amorphous waxy maize starches dried using different methods were examined. A gelatinized waxy maize starch paste (10% solids in water) was either freeze‐dried or oven‐dried (40 or 105°C) until the moisture content reached to <5%. To form the tablets, the dried amorphous starch powders, either with or without theophylline (3 : 10, w/w), were remoistened to a water content of (17 ± 0.2)%, and compressed into tablets. The drying process applied to the amorphous starch powders affected both the compactness and swelling behavior of the tablets. Although no crystallinity was detected in all the starches tested, X‐ray diffraction patterns indicated that starch chains dried at the lower temperature (40°C) are allowed more time to re‐associate during the drying process than those dried at the higher temperature (105°C). The freeze‐dried starch powders formed tablets characterized by greater compactness and rigidity than was observed in the oven‐dried starch samples. The drug release of the tablets prepared with the starch dried at the higher temperature (105°C) occurred at a much slower rate than that of the tablets made with the starch dried at the lower temperature (40°C). The drug release characteristics of the freeze‐dried starch tablets were nearly identical to those of the tablets prepared with the starch dried at 105°C. © 2007 Wiley Periodicals, Inc. J Appl Polym Sci, 2007</abstract><cop>Hoboken</cop><pub>Wiley Subscription Services, Inc., A Wiley Company</pub><doi>10.1002/app.26239</doi><tpages>6</tpages></addata></record> |
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| source | Wiley Online Library Journals Frontfile Complete |
| subjects | amorphous Applied sciences Biological and medical sciences compression drug release Exact sciences and technology Forms of application and semi-finished materials General pharmacology Medical sciences Miscellaneous Pharmaceutical technology. Pharmaceutical industry Pharmacology. Drug treatments Polymer industry, paints, wood swelling Technology of polymers waxy maize starch |
| title | Effects of drying process for amorphous waxy maize starch on theophylline release from starch-based tablets |
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