The Characterization of PLGA/Small Intestinal Submucosa Composites as Scaffolds for Intervertebral Disc
In order to application for the tissue engineered intervertebral disc (IVD), we designed the synthetic/natural hybrid scaffolds with poly(lactide-co-glycolide) (PLGA) and small intestine submucosa (SIS). SIS has been widely used as a biomaterial because SIS consists of various collagens and cytokine...
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| Veröffentlicht in: | Key engineering materials 2007-07, Vol.342-343, p.389-392 |
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| container_title | Key engineering materials |
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| creator | Choi, Bang Sil Ha, Hyun Jung Lee, Hai Bang Khang, Gil Son Yoon, Sun Jung Kim, Soon Hee Rhee, John M. Kim, Moon Suk Ko, Youn Kyung |
| description | In order to application for the tissue engineered intervertebral disc (IVD), we designed
the synthetic/natural hybrid scaffolds with poly(lactide-co-glycolide) (PLGA) and small intestine
submucosa (SIS). SIS has been widely used as a biomaterial because SIS consists of various
collagens and cytokines. SIS, however, possesses disadvantages such as their weak mechanical
properties and uncontrolled degradation. Novel composite scaffolds of PLGA/SIS were
manufactured by simple immersion method of PLGA scaffolds in SIS solution under vacuum. Then
SIS was crosslinked. Also, PLGA scaffolds and SIS sponges were manufactured by solvent
casting/salt leaching and freeze-dried methods, respectively. We evaluated pore structure, porosity,
water absorption ability and cell viability of three types of scaffolds for the application of IVD. |
| doi_str_mv | 10.4028/www.scientific.net/KEM.342-343.389 |
| format | Article |
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the synthetic/natural hybrid scaffolds with poly(lactide-co-glycolide) (PLGA) and small intestine
submucosa (SIS). SIS has been widely used as a biomaterial because SIS consists of various
collagens and cytokines. SIS, however, possesses disadvantages such as their weak mechanical
properties and uncontrolled degradation. Novel composite scaffolds of PLGA/SIS were
manufactured by simple immersion method of PLGA scaffolds in SIS solution under vacuum. Then
SIS was crosslinked. Also, PLGA scaffolds and SIS sponges were manufactured by solvent
casting/salt leaching and freeze-dried methods, respectively. We evaluated pore structure, porosity,
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the synthetic/natural hybrid scaffolds with poly(lactide-co-glycolide) (PLGA) and small intestine
submucosa (SIS). SIS has been widely used as a biomaterial because SIS consists of various
collagens and cytokines. SIS, however, possesses disadvantages such as their weak mechanical
properties and uncontrolled degradation. Novel composite scaffolds of PLGA/SIS were
manufactured by simple immersion method of PLGA scaffolds in SIS solution under vacuum. Then
SIS was crosslinked. Also, PLGA scaffolds and SIS sponges were manufactured by solvent
casting/salt leaching and freeze-dried methods, respectively. We evaluated pore structure, porosity,
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the synthetic/natural hybrid scaffolds with poly(lactide-co-glycolide) (PLGA) and small intestine
submucosa (SIS). SIS has been widely used as a biomaterial because SIS consists of various
collagens and cytokines. SIS, however, possesses disadvantages such as their weak mechanical
properties and uncontrolled degradation. Novel composite scaffolds of PLGA/SIS were
manufactured by simple immersion method of PLGA scaffolds in SIS solution under vacuum. Then
SIS was crosslinked. Also, PLGA scaffolds and SIS sponges were manufactured by solvent
casting/salt leaching and freeze-dried methods, respectively. We evaluated pore structure, porosity,
water absorption ability and cell viability of three types of scaffolds for the application of IVD.</abstract><pub>Trans Tech Publications Ltd</pub><doi>10.4028/www.scientific.net/KEM.342-343.389</doi><tpages>4</tpages></addata></record> |
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| title | The Characterization of PLGA/Small Intestinal Submucosa Composites as Scaffolds for Intervertebral Disc |
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