Enhance of Tumor Targeting by Receptor-Mediated Endocytosis Using Low Molecular Water-Soluble Chitosan Nanoparticles Loaded with Anticancer Agent
In this study, we prepared using low molecular weight water-soluble chitosan nanoparticle loaded paclitaxel (LMWSC-NPT) and investigated the potential as a drug carrier which is able to accumulate in the tumor site. In the experiment of receptor-mediated endocytosis, LMWSC-NPT was treated with sodiu...
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| Veröffentlicht in: | Key engineering materials 2007-07, Vol.342-343, p.469-472 |
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| container_title | Key engineering materials |
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| creator | Jang, Mi Kyeong Choi, Chang Yong Nah, Jae Woon Kim, Dong Gon Jang, Min Ja Kim, Tae Hyeong |
| description | In this study, we prepared using low molecular weight water-soluble chitosan nanoparticle loaded
paclitaxel (LMWSC-NPT) and investigated the potential as a drug carrier which is able to accumulate in the
tumor site. In the experiment of receptor-mediated endocytosis, LMWSC-NPT was treated with sodium azid
(NaN3) as an inhibitor of endocytosis process. As results, the antitumor activity of LMWSC-NPT treated
with sodium azid didn’t show but LMWSC-NPT was shown the high antitumor activity. Therefore,
LMWSC-NPs modified with hydrophobic group will be useful anticancer agent carrier via receptor-mediated
endocytosis. |
| doi_str_mv | 10.4028/www.scientific.net/KEM.342-343.469 |
| format | Article |
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paclitaxel (LMWSC-NPT) and investigated the potential as a drug carrier which is able to accumulate in the
tumor site. In the experiment of receptor-mediated endocytosis, LMWSC-NPT was treated with sodium azid
(NaN3) as an inhibitor of endocytosis process. As results, the antitumor activity of LMWSC-NPT treated
with sodium azid didn’t show but LMWSC-NPT was shown the high antitumor activity. Therefore,
LMWSC-NPs modified with hydrophobic group will be useful anticancer agent carrier via receptor-mediated
endocytosis.</description><identifier>ISSN: 1013-9826</identifier><identifier>ISSN: 1662-9795</identifier><identifier>EISSN: 1662-9795</identifier><identifier>DOI: 10.4028/www.scientific.net/KEM.342-343.469</identifier><language>eng</language><publisher>Trans Tech Publications Ltd</publisher><ispartof>Key engineering materials, 2007-07, Vol.342-343, p.469-472</ispartof><rights>2007 Trans Tech Publications Ltd</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c301t-8e256eed97b46ec0c46696418a5dc9965cacfdc84ca2366d74c6b5db0429d7d33</citedby><cites>FETCH-LOGICAL-c301t-8e256eed97b46ec0c46696418a5dc9965cacfdc84ca2366d74c6b5db0429d7d33</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Uhttps://www.scientific.net/Image/TitleCover/66?width=600</thumbnail><link.rule.ids>314,778,782,27907,27908</link.rule.ids></links><search><creatorcontrib>Jang, Mi Kyeong</creatorcontrib><creatorcontrib>Choi, Chang Yong</creatorcontrib><creatorcontrib>Nah, Jae Woon</creatorcontrib><creatorcontrib>Kim, Dong Gon</creatorcontrib><creatorcontrib>Jang, Min Ja</creatorcontrib><creatorcontrib>Kim, Tae Hyeong</creatorcontrib><title>Enhance of Tumor Targeting by Receptor-Mediated Endocytosis Using Low Molecular Water-Soluble Chitosan Nanoparticles Loaded with Anticancer Agent</title><title>Key engineering materials</title><description>In this study, we prepared using low molecular weight water-soluble chitosan nanoparticle loaded
paclitaxel (LMWSC-NPT) and investigated the potential as a drug carrier which is able to accumulate in the
tumor site. In the experiment of receptor-mediated endocytosis, LMWSC-NPT was treated with sodium azid
(NaN3) as an inhibitor of endocytosis process. As results, the antitumor activity of LMWSC-NPT treated
with sodium azid didn’t show but LMWSC-NPT was shown the high antitumor activity. Therefore,
LMWSC-NPs modified with hydrophobic group will be useful anticancer agent carrier via receptor-mediated
endocytosis.</description><issn>1013-9826</issn><issn>1662-9795</issn><issn>1662-9795</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2007</creationdate><recordtype>article</recordtype><recordid>eNqVkcGO0zAQhiME0i4L7-ATB6Rkk9hx4mMpXUDbstLS1R4tZzxpvUrtYjuK-hi8Ma66EmcO1vjwza_59WXZ56osWFl3t_M8FwEM2mgGA4XFeHu_2hSU1TlltGBcvMmuK87rXLSieZv-ZUVz0dX8KnsfwktZ0qqrmuvsz8rulQUkbiDb6eA82Sq_w2jsjvQn8oiAx-h8vkFtVERNVlY7OEUXTCBP4Yyt3Uw2bkSYRuXJc6J8_suNUz8iWe5NQpUlP5V1R-WjgRFDWlE6Zc0m7skidYDzCZ4sdqnQh-zdoMaAH1_nTfZ0t9ouv-frh28_lot1DrSsYt5h3XBELdqecYQSGOeCs6pTjQYheAMKBg0dA1VTznXLgPeN7ktWC91qSm-yT5fco3e_JwxRHkwAHEdl0U1B1qLrWNvyBH65gOBdCB4HefTmoPxJVqU825DJhvxnQyYbMtmQyUZ6VCYbKeTrJSR6ZUNE2MsXN3mbGv5PzF_hcKEl</recordid><startdate>20070715</startdate><enddate>20070715</enddate><creator>Jang, Mi Kyeong</creator><creator>Choi, Chang Yong</creator><creator>Nah, Jae Woon</creator><creator>Kim, Dong Gon</creator><creator>Jang, Min Ja</creator><creator>Kim, Tae Hyeong</creator><general>Trans Tech Publications Ltd</general><scope>AAYXX</scope><scope>CITATION</scope><scope>7SR</scope><scope>8BQ</scope><scope>8FD</scope><scope>JG9</scope></search><sort><creationdate>20070715</creationdate><title>Enhance of Tumor Targeting by Receptor-Mediated Endocytosis Using Low Molecular Water-Soluble Chitosan Nanoparticles Loaded with Anticancer Agent</title><author>Jang, Mi Kyeong ; Choi, Chang Yong ; Nah, Jae Woon ; Kim, Dong Gon ; Jang, Min Ja ; Kim, Tae Hyeong</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c301t-8e256eed97b46ec0c46696418a5dc9965cacfdc84ca2366d74c6b5db0429d7d33</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2007</creationdate><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Jang, Mi Kyeong</creatorcontrib><creatorcontrib>Choi, Chang Yong</creatorcontrib><creatorcontrib>Nah, Jae Woon</creatorcontrib><creatorcontrib>Kim, Dong Gon</creatorcontrib><creatorcontrib>Jang, Min Ja</creatorcontrib><creatorcontrib>Kim, Tae Hyeong</creatorcontrib><collection>CrossRef</collection><collection>Engineered Materials Abstracts</collection><collection>METADEX</collection><collection>Technology Research Database</collection><collection>Materials Research Database</collection><jtitle>Key engineering materials</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Jang, Mi Kyeong</au><au>Choi, Chang Yong</au><au>Nah, Jae Woon</au><au>Kim, Dong Gon</au><au>Jang, Min Ja</au><au>Kim, Tae Hyeong</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Enhance of Tumor Targeting by Receptor-Mediated Endocytosis Using Low Molecular Water-Soluble Chitosan Nanoparticles Loaded with Anticancer Agent</atitle><jtitle>Key engineering materials</jtitle><date>2007-07-15</date><risdate>2007</risdate><volume>342-343</volume><spage>469</spage><epage>472</epage><pages>469-472</pages><issn>1013-9826</issn><issn>1662-9795</issn><eissn>1662-9795</eissn><abstract>In this study, we prepared using low molecular weight water-soluble chitosan nanoparticle loaded
paclitaxel (LMWSC-NPT) and investigated the potential as a drug carrier which is able to accumulate in the
tumor site. In the experiment of receptor-mediated endocytosis, LMWSC-NPT was treated with sodium azid
(NaN3) as an inhibitor of endocytosis process. As results, the antitumor activity of LMWSC-NPT treated
with sodium azid didn’t show but LMWSC-NPT was shown the high antitumor activity. Therefore,
LMWSC-NPs modified with hydrophobic group will be useful anticancer agent carrier via receptor-mediated
endocytosis.</abstract><pub>Trans Tech Publications Ltd</pub><doi>10.4028/www.scientific.net/KEM.342-343.469</doi><tpages>4</tpages></addata></record> |
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| title | Enhance of Tumor Targeting by Receptor-Mediated Endocytosis Using Low Molecular Water-Soluble Chitosan Nanoparticles Loaded with Anticancer Agent |
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