Variations in the carbohydrate expression pattern and in lesions of the uterine horns of BALB/c mice infected with different Tritrichomonas foetus isolates
Bovine tritrichomonosis, a sexually transmitted disease caused by the protozoan Tritrichomonas foetus, is characterized by producing reproductive alterations in cattle. Carbohydrates on the surface of the uterine epithelium are involved in the process of adhesion and colonization of the protozoan. T...
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| Veröffentlicht in: | Research in veterinary science 2022-12, Vol.152, p.633-639 |
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| creator | Falcón, J.E. Rivero, M.B. Doumecq, M.L. Soto, P. Monteavaro, C.E Woudwyk, M.A. Barbeito, C.G. |
| description | Bovine tritrichomonosis, a sexually transmitted disease caused by the protozoan Tritrichomonas foetus, is characterized by producing reproductive alterations in cattle. Carbohydrates on the surface of the uterine epithelium are involved in the process of adhesion and colonization of the protozoan. The murine model has proved to be an inexpensive, practical and representative alternative to study the lesions produced in the natural host. For this work, during the first stage, 6–8 week old female BALB/c mice were inoculated with 24 different T. foetus isolates in order to classify them according to their pathogenicity. Then, seven isolates were selected and processed with lectin histochemistry to determine if the differences in pathogenicity corresponded to the changes found in the uterine carbohydrate expression pattern. In this work, we demonstrate the differences in the expression of the carbohydrate pattern between infected and uninfected mice. In addition, within the group of infected mice, differences were found in the degree of pathogenicity of the isolates, thus evidencing their biological variability.
•Variability in carbohydrate expression caused by different isolates of T. foetus.•Importance of murine infection-model for the study of Bovine tritrichomonosis.•First report of the behaviour of different isolates of T. foetus in a mouse model.•Importance of the carbohydrates in the pathogenesis of tritrichomonosis. |
| doi_str_mv | 10.1016/j.rvsc.2022.09.029 |
| format | Article |
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•Variability in carbohydrate expression caused by different isolates of T. foetus.•Importance of murine infection-model for the study of Bovine tritrichomonosis.•First report of the behaviour of different isolates of T. foetus in a mouse model.•Importance of the carbohydrates in the pathogenesis of tritrichomonosis.</description><identifier>ISSN: 0034-5288</identifier><identifier>EISSN: 1532-2661</identifier><identifier>DOI: 10.1016/j.rvsc.2022.09.029</identifier><identifier>PMID: 36209616</identifier><language>eng</language><publisher>England: Elsevier Ltd</publisher><subject>adhesion ; Animal models ; Animals ; Carbohydrates ; Cattle ; Cattle Diseases - metabolism ; Colonization ; Disease transmission ; Endometrium ; Epithelium ; Experimental models ; Female ; females ; Fetuses ; Genetic testing ; Histochemistry ; Infections ; Laboratory animals ; Lectins ; Lesions ; Mice ; Mice, Inbred BALB C ; Pathogenesis ; Pathogenicity ; Pathogens ; Protozoan Infections, Animal - metabolism ; Protozoan Infections, Animal - pathology ; Sexually transmitted diseases ; STD ; Tritrichomonas foetus ; Tritrichomonosis ; Uterus ; Uterus - pathology ; Veterinary medicine</subject><ispartof>Research in veterinary science, 2022-12, Vol.152, p.633-639</ispartof><rights>2022 Elsevier Ltd</rights><rights>Copyright © 2022 Elsevier Ltd. All rights reserved.</rights><rights>2022. Elsevier Ltd</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c347t-324a88d00e761587753e0c436e23137b325a112fad308b6c4824c1384be3ab583</citedby><cites>FETCH-LOGICAL-c347t-324a88d00e761587753e0c436e23137b325a112fad308b6c4824c1384be3ab583</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktohtml>$$Uhttps://www.sciencedirect.com/science/article/pii/S0034528822003095$$EHTML$$P50$$Gelsevier$$H</linktohtml><link.rule.ids>314,776,780,3537,27901,27902,65306</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/36209616$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Falcón, J.E.</creatorcontrib><creatorcontrib>Rivero, M.B.</creatorcontrib><creatorcontrib>Doumecq, M.L.</creatorcontrib><creatorcontrib>Soto, P.</creatorcontrib><creatorcontrib>Monteavaro, C.E</creatorcontrib><creatorcontrib>Woudwyk, M.A.</creatorcontrib><creatorcontrib>Barbeito, C.G.</creatorcontrib><title>Variations in the carbohydrate expression pattern and in lesions of the uterine horns of BALB/c mice infected with different Tritrichomonas foetus isolates</title><title>Research in veterinary science</title><addtitle>Res Vet Sci</addtitle><description>Bovine tritrichomonosis, a sexually transmitted disease caused by the protozoan Tritrichomonas foetus, is characterized by producing reproductive alterations in cattle. Carbohydrates on the surface of the uterine epithelium are involved in the process of adhesion and colonization of the protozoan. The murine model has proved to be an inexpensive, practical and representative alternative to study the lesions produced in the natural host. For this work, during the first stage, 6–8 week old female BALB/c mice were inoculated with 24 different T. foetus isolates in order to classify them according to their pathogenicity. Then, seven isolates were selected and processed with lectin histochemistry to determine if the differences in pathogenicity corresponded to the changes found in the uterine carbohydrate expression pattern. In this work, we demonstrate the differences in the expression of the carbohydrate pattern between infected and uninfected mice. In addition, within the group of infected mice, differences were found in the degree of pathogenicity of the isolates, thus evidencing their biological variability.
•Variability in carbohydrate expression caused by different isolates of T. foetus.•Importance of murine infection-model for the study of Bovine tritrichomonosis.•First report of the behaviour of different isolates of T. foetus in a mouse model.•Importance of the carbohydrates in the pathogenesis of tritrichomonosis.</description><subject>adhesion</subject><subject>Animal models</subject><subject>Animals</subject><subject>Carbohydrates</subject><subject>Cattle</subject><subject>Cattle Diseases - metabolism</subject><subject>Colonization</subject><subject>Disease transmission</subject><subject>Endometrium</subject><subject>Epithelium</subject><subject>Experimental models</subject><subject>Female</subject><subject>females</subject><subject>Fetuses</subject><subject>Genetic testing</subject><subject>Histochemistry</subject><subject>Infections</subject><subject>Laboratory animals</subject><subject>Lectins</subject><subject>Lesions</subject><subject>Mice</subject><subject>Mice, Inbred BALB C</subject><subject>Pathogenesis</subject><subject>Pathogenicity</subject><subject>Pathogens</subject><subject>Protozoan Infections, Animal - metabolism</subject><subject>Protozoan Infections, Animal - pathology</subject><subject>Sexually transmitted diseases</subject><subject>STD</subject><subject>Tritrichomonas foetus</subject><subject>Tritrichomonosis</subject><subject>Uterus</subject><subject>Uterus - pathology</subject><subject>Veterinary medicine</subject><issn>0034-5288</issn><issn>1532-2661</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2022</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNqFkctu1DAUhi0EokPhBVggS2zYJPUtjiOxaStu0khsClvLcU4UjxJ7sJ1Cn4WXxekUFixgZcnn-39fPoReUlJTQuXFoY63ydaMMFaTriase4R2tOGsYlLSx2hHCBdVw5Q6Q89SOhBCBKXtU3TGJSOdpHKHfn410Znsgk_YeZwnwNbEPkx3QzQZMPw4RkipzPHR5AzRY-OHDZ0h3afCeJ9ay8x5wFOIp82ry_3VhcWLs1DwEWyGAX93ecKDG0eI4DO-iS5HZ6ewBG8SHgPktdwjhbmcnZ6jJ6OZE7x4WM_Rl_fvbq4_VvvPHz5dX-4ry0WbK86EUWogBFpJG9W2DQdiBZfAOOVtz1ljKGWjGThRvbRCMWEpV6IHbvpG8XP05tR7jOHbCinrxSUL82w8hDVp1qmmY4Jz9n-0ZVwoLrumoK__Qg9hjb48ZKM60nIpukKxE2VjSCnCqI_RLSbeaUr0Zlkf9GZZb5Y16XSxXEKvHqrXfoHhT-S31gK8PQFQvu3WQdTJOvAWBheLCD0E96_-X31huYc</recordid><startdate>20221220</startdate><enddate>20221220</enddate><creator>Falcón, J.E.</creator><creator>Rivero, M.B.</creator><creator>Doumecq, M.L.</creator><creator>Soto, P.</creator><creator>Monteavaro, C.E</creator><creator>Woudwyk, M.A.</creator><creator>Barbeito, C.G.</creator><general>Elsevier Ltd</general><general>Elsevier Limited</general><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7QG</scope><scope>7QP</scope><scope>7QR</scope><scope>7T5</scope><scope>7T7</scope><scope>7TK</scope><scope>7TM</scope><scope>7TO</scope><scope>7U7</scope><scope>7U9</scope><scope>8FD</scope><scope>C1K</scope><scope>FR3</scope><scope>H94</scope><scope>K9.</scope><scope>M7N</scope><scope>P64</scope><scope>7X8</scope><scope>7S9</scope><scope>L.6</scope></search><sort><creationdate>20221220</creationdate><title>Variations in the carbohydrate expression pattern and in lesions of the uterine horns of BALB/c mice infected with different Tritrichomonas foetus isolates</title><author>Falcón, J.E. ; Rivero, M.B. ; Doumecq, M.L. ; Soto, P. ; Monteavaro, C.E ; Woudwyk, M.A. ; Barbeito, C.G.</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c347t-324a88d00e761587753e0c436e23137b325a112fad308b6c4824c1384be3ab583</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2022</creationdate><topic>adhesion</topic><topic>Animal models</topic><topic>Animals</topic><topic>Carbohydrates</topic><topic>Cattle</topic><topic>Cattle Diseases - metabolism</topic><topic>Colonization</topic><topic>Disease transmission</topic><topic>Endometrium</topic><topic>Epithelium</topic><topic>Experimental models</topic><topic>Female</topic><topic>females</topic><topic>Fetuses</topic><topic>Genetic testing</topic><topic>Histochemistry</topic><topic>Infections</topic><topic>Laboratory animals</topic><topic>Lectins</topic><topic>Lesions</topic><topic>Mice</topic><topic>Mice, Inbred BALB C</topic><topic>Pathogenesis</topic><topic>Pathogenicity</topic><topic>Pathogens</topic><topic>Protozoan Infections, Animal - metabolism</topic><topic>Protozoan Infections, Animal - pathology</topic><topic>Sexually transmitted diseases</topic><topic>STD</topic><topic>Tritrichomonas foetus</topic><topic>Tritrichomonosis</topic><topic>Uterus</topic><topic>Uterus - pathology</topic><topic>Veterinary medicine</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Falcón, J.E.</creatorcontrib><creatorcontrib>Rivero, M.B.</creatorcontrib><creatorcontrib>Doumecq, M.L.</creatorcontrib><creatorcontrib>Soto, P.</creatorcontrib><creatorcontrib>Monteavaro, C.E</creatorcontrib><creatorcontrib>Woudwyk, M.A.</creatorcontrib><creatorcontrib>Barbeito, C.G.</creatorcontrib><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>Animal Behavior Abstracts</collection><collection>Calcium & Calcified Tissue Abstracts</collection><collection>Chemoreception Abstracts</collection><collection>Immunology Abstracts</collection><collection>Industrial and Applied Microbiology Abstracts (Microbiology A)</collection><collection>Neurosciences Abstracts</collection><collection>Nucleic Acids Abstracts</collection><collection>Oncogenes and Growth Factors Abstracts</collection><collection>Toxicology Abstracts</collection><collection>Virology and AIDS Abstracts</collection><collection>Technology Research Database</collection><collection>Environmental Sciences and Pollution Management</collection><collection>Engineering Research Database</collection><collection>AIDS and Cancer Research Abstracts</collection><collection>ProQuest Health & Medical Complete (Alumni)</collection><collection>Algology Mycology and Protozoology Abstracts (Microbiology C)</collection><collection>Biotechnology and BioEngineering Abstracts</collection><collection>MEDLINE - Academic</collection><collection>AGRICOLA</collection><collection>AGRICOLA - Academic</collection><jtitle>Research in veterinary science</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Falcón, J.E.</au><au>Rivero, M.B.</au><au>Doumecq, M.L.</au><au>Soto, P.</au><au>Monteavaro, C.E</au><au>Woudwyk, M.A.</au><au>Barbeito, C.G.</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Variations in the carbohydrate expression pattern and in lesions of the uterine horns of BALB/c mice infected with different Tritrichomonas foetus isolates</atitle><jtitle>Research in veterinary science</jtitle><addtitle>Res Vet Sci</addtitle><date>2022-12-20</date><risdate>2022</risdate><volume>152</volume><spage>633</spage><epage>639</epage><pages>633-639</pages><issn>0034-5288</issn><eissn>1532-2661</eissn><abstract>Bovine tritrichomonosis, a sexually transmitted disease caused by the protozoan Tritrichomonas foetus, is characterized by producing reproductive alterations in cattle. Carbohydrates on the surface of the uterine epithelium are involved in the process of adhesion and colonization of the protozoan. The murine model has proved to be an inexpensive, practical and representative alternative to study the lesions produced in the natural host. For this work, during the first stage, 6–8 week old female BALB/c mice were inoculated with 24 different T. foetus isolates in order to classify them according to their pathogenicity. Then, seven isolates were selected and processed with lectin histochemistry to determine if the differences in pathogenicity corresponded to the changes found in the uterine carbohydrate expression pattern. In this work, we demonstrate the differences in the expression of the carbohydrate pattern between infected and uninfected mice. In addition, within the group of infected mice, differences were found in the degree of pathogenicity of the isolates, thus evidencing their biological variability.
•Variability in carbohydrate expression caused by different isolates of T. foetus.•Importance of murine infection-model for the study of Bovine tritrichomonosis.•First report of the behaviour of different isolates of T. foetus in a mouse model.•Importance of the carbohydrates in the pathogenesis of tritrichomonosis.</abstract><cop>England</cop><pub>Elsevier Ltd</pub><pmid>36209616</pmid><doi>10.1016/j.rvsc.2022.09.029</doi><tpages>7</tpages></addata></record> |
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| subjects | adhesion Animal models Animals Carbohydrates Cattle Cattle Diseases - metabolism Colonization Disease transmission Endometrium Epithelium Experimental models Female females Fetuses Genetic testing Histochemistry Infections Laboratory animals Lectins Lesions Mice Mice, Inbred BALB C Pathogenesis Pathogenicity Pathogens Protozoan Infections, Animal - metabolism Protozoan Infections, Animal - pathology Sexually transmitted diseases STD Tritrichomonas foetus Tritrichomonosis Uterus Uterus - pathology Veterinary medicine |
| title | Variations in the carbohydrate expression pattern and in lesions of the uterine horns of BALB/c mice infected with different Tritrichomonas foetus isolates |
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