Assessment of the Efficiency of Tulsi Extract as a Locally Administered Medication Agent and Its Comparison With Curcumin in the Treatment of Periodontal Pockets
The use of locally administered medication (LAM) agents such as minocycline, metronidazole, and tetracycline as antimicrobials has drawbacks, including the development of microorganism resistance, exorbitant pricing, and limited accessibility. Thus, there is a need for safer and more affordable alte...
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| Veröffentlicht in: | Curēus (Palo Alto, CA) CA), 2024-02, Vol.16 (2), p.e54619-e54619 |
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| creator | Agrawal, Ankita Sharma, Anant Ragav Rathod, Varsha Bhatnagar, Anand Amol Khale, Pallavi Tidke, Priyanka Mehta, Dhaval Mazumder, Debojyoti |
| description | The use of locally administered medication (LAM) agents such as minocycline, metronidazole, and tetracycline as antimicrobials has drawbacks, including the development of microorganism resistance, exorbitant pricing, and limited accessibility. Thus, there is a need for safer and more affordable alternatives. Numerous natural therapies have been found to be superior in this situation. In this study, the efficacy of tulsi extract as a LAM agent was assessed and it was compared with curcumin, which is currently used for the treatment of periodontal pockets.
There were three categories: each category had 30 sites. Category 1 sites underwent scaling along with root planing (SRP) solely, Category 2 sites received curcumin extract as LAM in the periodontal pocket in addition to SRP, and Category 3 sites received tulsi extract as LAM in the periodontal pocket in addition to SRP. The stent was used to ensure consistent and unbiased measurements on the 30th day after treatment. Clinical attachment level (CAL) and probing pocket depth (PPD) were measured at six points around each tooth. Results: The reduction in values of periodontal parameters such as BAPNA (Nα-benzoyl-DL-arginine-p-nitroanilide) assays, modified sulcus bleeding index (mSBI), gingival index (GI), plaque index (PI), CAL, and PPD in sites within Category 1, Category 2, and Category 3 was statistically significant. The decrease in BAPNA assay results indicates that tulsi extract is more effective than curcumin gel at eradicating red-complex bacteria. Although not significantly different, the decrease in PI and GI was observed to be greater when curcumin jelly was used. This suggests that curcumin jelly has a stronger impact on reducing plaque, which in turn decreases gingival inflammation.
Based on the overall results of the study, it can be said that both tulsi and curcumin have similar effectiveness in reducing periodontal markers. |
| doi_str_mv | 10.7759/cureus.54619 |
| format | Article |
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There were three categories: each category had 30 sites. Category 1 sites underwent scaling along with root planing (SRP) solely, Category 2 sites received curcumin extract as LAM in the periodontal pocket in addition to SRP, and Category 3 sites received tulsi extract as LAM in the periodontal pocket in addition to SRP. The stent was used to ensure consistent and unbiased measurements on the 30th day after treatment. Clinical attachment level (CAL) and probing pocket depth (PPD) were measured at six points around each tooth. Results: The reduction in values of periodontal parameters such as BAPNA (Nα-benzoyl-DL-arginine-p-nitroanilide) assays, modified sulcus bleeding index (mSBI), gingival index (GI), plaque index (PI), CAL, and PPD in sites within Category 1, Category 2, and Category 3 was statistically significant. The decrease in BAPNA assay results indicates that tulsi extract is more effective than curcumin gel at eradicating red-complex bacteria. Although not significantly different, the decrease in PI and GI was observed to be greater when curcumin jelly was used. This suggests that curcumin jelly has a stronger impact on reducing plaque, which in turn decreases gingival inflammation.
Based on the overall results of the study, it can be said that both tulsi and curcumin have similar effectiveness in reducing periodontal markers.</description><identifier>ISSN: 2168-8184</identifier><identifier>EISSN: 2168-8184</identifier><identifier>DOI: 10.7759/cureus.54619</identifier><identifier>PMID: 38523946</identifier><language>eng</language><publisher>United States: Cureus Inc</publisher><subject>Antimicrobial agents ; Bacteria ; Gum disease ; Inflammation ; Mouth ; Neutrophils ; Pathogens</subject><ispartof>Curēus (Palo Alto, CA), 2024-02, Vol.16 (2), p.e54619-e54619</ispartof><rights>Copyright © 2024, Agrawal et al.</rights><rights>Copyright © 2024, Agrawal et al. This work is published under https://creativecommons.org/licenses/by/4.0/ (the “License”). Notwithstanding the ProQuest Terms and Conditions, you may use this content in accordance with the terms of the License.</rights><lds50>peer_reviewed</lds50><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c287t-3137251524cd950a140d73251780061fa643e96d2076d713d8bb91d1ba3f20273</citedby><cites>FETCH-LOGICAL-c287t-3137251524cd950a140d73251780061fa643e96d2076d713d8bb91d1ba3f20273</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><link.rule.ids>314,776,780,27901,27902</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/38523946$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Agrawal, Ankita</creatorcontrib><creatorcontrib>Sharma, Anant Ragav</creatorcontrib><creatorcontrib>Rathod, Varsha</creatorcontrib><creatorcontrib>Bhatnagar, Anand</creatorcontrib><creatorcontrib>Amol Khale, Pallavi</creatorcontrib><creatorcontrib>Tidke, Priyanka</creatorcontrib><creatorcontrib>Mehta, Dhaval</creatorcontrib><creatorcontrib>Mazumder, Debojyoti</creatorcontrib><title>Assessment of the Efficiency of Tulsi Extract as a Locally Administered Medication Agent and Its Comparison With Curcumin in the Treatment of Periodontal Pockets</title><title>Curēus (Palo Alto, CA)</title><addtitle>Cureus</addtitle><description>The use of locally administered medication (LAM) agents such as minocycline, metronidazole, and tetracycline as antimicrobials has drawbacks, including the development of microorganism resistance, exorbitant pricing, and limited accessibility. Thus, there is a need for safer and more affordable alternatives. Numerous natural therapies have been found to be superior in this situation. In this study, the efficacy of tulsi extract as a LAM agent was assessed and it was compared with curcumin, which is currently used for the treatment of periodontal pockets.
There were three categories: each category had 30 sites. Category 1 sites underwent scaling along with root planing (SRP) solely, Category 2 sites received curcumin extract as LAM in the periodontal pocket in addition to SRP, and Category 3 sites received tulsi extract as LAM in the periodontal pocket in addition to SRP. The stent was used to ensure consistent and unbiased measurements on the 30th day after treatment. Clinical attachment level (CAL) and probing pocket depth (PPD) were measured at six points around each tooth. Results: The reduction in values of periodontal parameters such as BAPNA (Nα-benzoyl-DL-arginine-p-nitroanilide) assays, modified sulcus bleeding index (mSBI), gingival index (GI), plaque index (PI), CAL, and PPD in sites within Category 1, Category 2, and Category 3 was statistically significant. The decrease in BAPNA assay results indicates that tulsi extract is more effective than curcumin gel at eradicating red-complex bacteria. Although not significantly different, the decrease in PI and GI was observed to be greater when curcumin jelly was used. This suggests that curcumin jelly has a stronger impact on reducing plaque, which in turn decreases gingival inflammation.
Based on the overall results of the study, it can be said that both tulsi and curcumin have similar effectiveness in reducing periodontal markers.</description><subject>Antimicrobial agents</subject><subject>Bacteria</subject><subject>Gum disease</subject><subject>Inflammation</subject><subject>Mouth</subject><subject>Neutrophils</subject><subject>Pathogens</subject><issn>2168-8184</issn><issn>2168-8184</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2024</creationdate><recordtype>article</recordtype><sourceid>BENPR</sourceid><recordid>eNpdkU9rGzEQxUVJaUKaW89F0EsOdao_uyvt0Rg3CTgkB5ceF1mabZTurlyNBPXH6TeNHCclBAQjZn56b9Aj5BNnF0rV7TebI2S8qKuGt-_IieCNnmmuq6NX92NyhvjAGONMCabYB3IsdS1kWzUn5N8cERBHmBINPU33QJd9762Hye72nXUe0NPl3xSNTdQgNXQVrBmGHZ270U8eE0Rw9Aactyb5MNH5r72amRy9TkgXYdya6LEMfvp0Txc52lwe0nL2dusIJr3430H0wYUpmYHeBfsbEn4k73szIJw911Py4_tyvbiarW4vrxfz1cwKrdJMcqlEzWtRWdfWzPCKOSVLR2nGGt6bppLQNq78QOMUl05vNi13fGNkL5hQ8pScH3S3MfzJgKkbPVoYBjNByNiJVteq1UI3Bf3yBn0IOU5lu06yYqC45rxQXw-UjQExQt9tox9N3HWcdfv0ukN63VN6Bf_8LJo3I7j_8EtW8hGfk5Z2</recordid><startdate>20240221</startdate><enddate>20240221</enddate><creator>Agrawal, Ankita</creator><creator>Sharma, Anant Ragav</creator><creator>Rathod, Varsha</creator><creator>Bhatnagar, Anand</creator><creator>Amol Khale, Pallavi</creator><creator>Tidke, Priyanka</creator><creator>Mehta, Dhaval</creator><creator>Mazumder, Debojyoti</creator><general>Cureus Inc</general><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>3V.</scope><scope>7X7</scope><scope>7XB</scope><scope>8FI</scope><scope>8FJ</scope><scope>8FK</scope><scope>ABUWG</scope><scope>AFKRA</scope><scope>AZQEC</scope><scope>BENPR</scope><scope>CCPQU</scope><scope>DWQXO</scope><scope>FYUFA</scope><scope>GHDGH</scope><scope>K9.</scope><scope>M0S</scope><scope>PIMPY</scope><scope>PQEST</scope><scope>PQQKQ</scope><scope>PQUKI</scope><scope>PRINS</scope><scope>7X8</scope></search><sort><creationdate>20240221</creationdate><title>Assessment of the Efficiency of Tulsi Extract as a Locally Administered Medication Agent and Its Comparison With Curcumin in the Treatment of Periodontal Pockets</title><author>Agrawal, Ankita ; Sharma, Anant Ragav ; Rathod, Varsha ; Bhatnagar, Anand ; Amol Khale, Pallavi ; Tidke, Priyanka ; Mehta, Dhaval ; Mazumder, Debojyoti</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c287t-3137251524cd950a140d73251780061fa643e96d2076d713d8bb91d1ba3f20273</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2024</creationdate><topic>Antimicrobial agents</topic><topic>Bacteria</topic><topic>Gum disease</topic><topic>Inflammation</topic><topic>Mouth</topic><topic>Neutrophils</topic><topic>Pathogens</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Agrawal, Ankita</creatorcontrib><creatorcontrib>Sharma, Anant Ragav</creatorcontrib><creatorcontrib>Rathod, Varsha</creatorcontrib><creatorcontrib>Bhatnagar, Anand</creatorcontrib><creatorcontrib>Amol Khale, Pallavi</creatorcontrib><creatorcontrib>Tidke, Priyanka</creatorcontrib><creatorcontrib>Mehta, Dhaval</creatorcontrib><creatorcontrib>Mazumder, Debojyoti</creatorcontrib><collection>PubMed</collection><collection>CrossRef</collection><collection>ProQuest Central (Corporate)</collection><collection>Health & Medical Collection</collection><collection>ProQuest Central (purchase pre-March 2016)</collection><collection>Hospital Premium Collection</collection><collection>Hospital Premium Collection (Alumni Edition)</collection><collection>ProQuest Central (Alumni) (purchase pre-March 2016)</collection><collection>ProQuest Central (Alumni Edition)</collection><collection>ProQuest Central UK/Ireland</collection><collection>ProQuest Central Essentials</collection><collection>ProQuest Central</collection><collection>ProQuest One Community College</collection><collection>ProQuest Central Korea</collection><collection>Health Research Premium Collection</collection><collection>Health Research Premium Collection (Alumni)</collection><collection>ProQuest Health & Medical Complete (Alumni)</collection><collection>Health & Medical Collection (Alumni Edition)</collection><collection>Publicly Available Content Database</collection><collection>ProQuest One Academic Eastern Edition (DO NOT USE)</collection><collection>ProQuest One Academic</collection><collection>ProQuest One Academic UKI Edition</collection><collection>ProQuest Central China</collection><collection>MEDLINE - Academic</collection><jtitle>Curēus (Palo Alto, CA)</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Agrawal, Ankita</au><au>Sharma, Anant Ragav</au><au>Rathod, Varsha</au><au>Bhatnagar, Anand</au><au>Amol Khale, Pallavi</au><au>Tidke, Priyanka</au><au>Mehta, Dhaval</au><au>Mazumder, Debojyoti</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Assessment of the Efficiency of Tulsi Extract as a Locally Administered Medication Agent and Its Comparison With Curcumin in the Treatment of Periodontal Pockets</atitle><jtitle>Curēus (Palo Alto, CA)</jtitle><addtitle>Cureus</addtitle><date>2024-02-21</date><risdate>2024</risdate><volume>16</volume><issue>2</issue><spage>e54619</spage><epage>e54619</epage><pages>e54619-e54619</pages><issn>2168-8184</issn><eissn>2168-8184</eissn><abstract>The use of locally administered medication (LAM) agents such as minocycline, metronidazole, and tetracycline as antimicrobials has drawbacks, including the development of microorganism resistance, exorbitant pricing, and limited accessibility. Thus, there is a need for safer and more affordable alternatives. Numerous natural therapies have been found to be superior in this situation. In this study, the efficacy of tulsi extract as a LAM agent was assessed and it was compared with curcumin, which is currently used for the treatment of periodontal pockets.
There were three categories: each category had 30 sites. Category 1 sites underwent scaling along with root planing (SRP) solely, Category 2 sites received curcumin extract as LAM in the periodontal pocket in addition to SRP, and Category 3 sites received tulsi extract as LAM in the periodontal pocket in addition to SRP. The stent was used to ensure consistent and unbiased measurements on the 30th day after treatment. Clinical attachment level (CAL) and probing pocket depth (PPD) were measured at six points around each tooth. Results: The reduction in values of periodontal parameters such as BAPNA (Nα-benzoyl-DL-arginine-p-nitroanilide) assays, modified sulcus bleeding index (mSBI), gingival index (GI), plaque index (PI), CAL, and PPD in sites within Category 1, Category 2, and Category 3 was statistically significant. The decrease in BAPNA assay results indicates that tulsi extract is more effective than curcumin gel at eradicating red-complex bacteria. Although not significantly different, the decrease in PI and GI was observed to be greater when curcumin jelly was used. This suggests that curcumin jelly has a stronger impact on reducing plaque, which in turn decreases gingival inflammation.
Based on the overall results of the study, it can be said that both tulsi and curcumin have similar effectiveness in reducing periodontal markers.</abstract><cop>United States</cop><pub>Cureus Inc</pub><pmid>38523946</pmid><doi>10.7759/cureus.54619</doi><oa>free_for_read</oa></addata></record> |
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| subjects | Antimicrobial agents Bacteria Gum disease Inflammation Mouth Neutrophils Pathogens |
| title | Assessment of the Efficiency of Tulsi Extract as a Locally Administered Medication Agent and Its Comparison With Curcumin in the Treatment of Periodontal Pockets |
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