The Association of Low-Carbohydrate Diet and HECTD4 rs11066280 Polymorphism with Risk of Colorectal Cancer: A Case-Control Study in Korea
Glucose is a main source of energy for tumor cells. Thus, a low-carbohydrate diet (LCD) is thought to make a significant contribution to cancer prevention. In addition, LCD and HECT domain E3 ubiquitin protein ligase 4 (HECTD4) gene may be related to insulin resistance. We explored whether LCD score...
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| Veröffentlicht in: | Current developments in nutrition 2024-03, Vol.8 (3), p.102127-102127, Article 102127 |
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| creator | Tran, Tao Thi Gunathilake, Madhawa Lee, Jeonghee Oh, Jae Hwan Chang, Hee Jin Sohn, Dae Kyung Shin, Aesun Kim, Jeongseon |
| description | Glucose is a main source of energy for tumor cells. Thus, a low-carbohydrate diet (LCD) is thought to make a significant contribution to cancer prevention. In addition, LCD and HECT domain E3 ubiquitin protein ligase 4 (HECTD4) gene may be related to insulin resistance.
We explored whether LCD score and HECTD4 rs11066280 are etiological factors for colorectal cancer (CRC) and whether LCD score interacts with HECTD4 rs11066280 to modify CRC risk.
We included 1457 controls and 1062 cases in a case-control study. The LCD score was computed based on the proportion of energy obtained from carbohydrate, protein, and fat, as determined by a semiquantitative food frequency questionnaire. We used unconditional logistic regression models to explore the association of HECTD4 with CRC prevention and interaction of LCD score and HECTD4 polymorphism with CRC preventability.
Individuals with AA/AT genotypes who carried a minor allele (A) of HECTD4 rs11066280 exhibited a decreased CRC risk [odds ratio (OR) = 0.75, 95% confidence interval (CI): 0.62, 0.91]. In addition, a protective effect of high LCD score against CRC development was identified (OR = 0.52, 95% CI: 0.40, 0.68, P for trend |
| doi_str_mv | 10.1016/j.cdnut.2024.102127 |
| format | Article |
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We explored whether LCD score and HECTD4 rs11066280 are etiological factors for colorectal cancer (CRC) and whether LCD score interacts with HECTD4 rs11066280 to modify CRC risk.
We included 1457 controls and 1062 cases in a case-control study. The LCD score was computed based on the proportion of energy obtained from carbohydrate, protein, and fat, as determined by a semiquantitative food frequency questionnaire. We used unconditional logistic regression models to explore the association of HECTD4 with CRC prevention and interaction of LCD score and HECTD4 polymorphism with CRC preventability.
Individuals with AA/AT genotypes who carried a minor allele (A) of HECTD4 rs11066280 exhibited a decreased CRC risk [odds ratio (OR) = 0.75, 95% confidence interval (CI): 0.62, 0.91]. In addition, a protective effect of high LCD score against CRC development was identified (OR = 0.52, 95% CI: 0.40, 0.68, P for trend <0.001). However, the effect of LCD depended on individual’s genetic background, which appears only in participants with TT genotype of HECTD4 rs11066280 [OR = 0.49 (0.36–0.68), P interaction = 0.044].
Our findings suggest a protective effect of LCD and a minor allele of HECTD4 rs11066280 against CRC development. In addition, we provide an understanding of the interaction effect of LCD and HECTD4 rs11066280 on CRC, which may be helpful for establishing diet plans regarding cancer prevention.</description><identifier>ISSN: 2475-2991</identifier><identifier>EISSN: 2475-2991</identifier><identifier>DOI: 10.1016/j.cdnut.2024.102127</identifier><identifier>PMID: 38523829</identifier><language>eng</language><publisher>United States: Elsevier Inc</publisher><subject>case-control study ; Colorectal cancer ; Genetic aspects ; Health aspects ; HECTD4 rs11066280 ; Korea ; Low-carbohydrate diet ; Physiological aspects ; Prevention ; Risk factors ; Single nucleotide polymorphisms ; Ubiquitin-proteasome system</subject><ispartof>Current developments in nutrition, 2024-03, Vol.8 (3), p.102127-102127, Article 102127</ispartof><rights>2024</rights><rights>2024 Published by Elsevier Inc. on behalf of American Society for Nutrition.</rights><rights>COPYRIGHT 2024 Oxford University Press</rights><lds50>peer_reviewed</lds50><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c426t-c5226143a9c8dffe8c3ca69ed61c492df25fa7923062ab1656c9fc0f4cfca3873</citedby><cites>FETCH-LOGICAL-c426t-c5226143a9c8dffe8c3ca69ed61c492df25fa7923062ab1656c9fc0f4cfca3873</cites><orcidid>0000-0002-0889-2686</orcidid></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><link.rule.ids>314,780,784,864,27923,27924</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/38523829$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Tran, Tao Thi</creatorcontrib><creatorcontrib>Gunathilake, Madhawa</creatorcontrib><creatorcontrib>Lee, Jeonghee</creatorcontrib><creatorcontrib>Oh, Jae Hwan</creatorcontrib><creatorcontrib>Chang, Hee Jin</creatorcontrib><creatorcontrib>Sohn, Dae Kyung</creatorcontrib><creatorcontrib>Shin, Aesun</creatorcontrib><creatorcontrib>Kim, Jeongseon</creatorcontrib><title>The Association of Low-Carbohydrate Diet and HECTD4 rs11066280 Polymorphism with Risk of Colorectal Cancer: A Case-Control Study in Korea</title><title>Current developments in nutrition</title><addtitle>Curr Dev Nutr</addtitle><description>Glucose is a main source of energy for tumor cells. Thus, a low-carbohydrate diet (LCD) is thought to make a significant contribution to cancer prevention. In addition, LCD and HECT domain E3 ubiquitin protein ligase 4 (HECTD4) gene may be related to insulin resistance.
We explored whether LCD score and HECTD4 rs11066280 are etiological factors for colorectal cancer (CRC) and whether LCD score interacts with HECTD4 rs11066280 to modify CRC risk.
We included 1457 controls and 1062 cases in a case-control study. The LCD score was computed based on the proportion of energy obtained from carbohydrate, protein, and fat, as determined by a semiquantitative food frequency questionnaire. We used unconditional logistic regression models to explore the association of HECTD4 with CRC prevention and interaction of LCD score and HECTD4 polymorphism with CRC preventability.
Individuals with AA/AT genotypes who carried a minor allele (A) of HECTD4 rs11066280 exhibited a decreased CRC risk [odds ratio (OR) = 0.75, 95% confidence interval (CI): 0.62, 0.91]. In addition, a protective effect of high LCD score against CRC development was identified (OR = 0.52, 95% CI: 0.40, 0.68, P for trend <0.001). However, the effect of LCD depended on individual’s genetic background, which appears only in participants with TT genotype of HECTD4 rs11066280 [OR = 0.49 (0.36–0.68), P interaction = 0.044].
Our findings suggest a protective effect of LCD and a minor allele of HECTD4 rs11066280 against CRC development. In addition, we provide an understanding of the interaction effect of LCD and HECTD4 rs11066280 on CRC, which may be helpful for establishing diet plans regarding cancer prevention.</description><subject>case-control study</subject><subject>Colorectal cancer</subject><subject>Genetic aspects</subject><subject>Health aspects</subject><subject>HECTD4 rs11066280</subject><subject>Korea</subject><subject>Low-carbohydrate diet</subject><subject>Physiological aspects</subject><subject>Prevention</subject><subject>Risk factors</subject><subject>Single nucleotide polymorphisms</subject><subject>Ubiquitin-proteasome system</subject><issn>2475-2991</issn><issn>2475-2991</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2024</creationdate><recordtype>article</recordtype><recordid>eNp9kdGK1DAUhoMo7rLuEwgS8Mabjknapo3gxdBdXXFA0fE6ZJITJ2PbjEnqMo_gW5vaVRREcpHD4ftPwvkQekzJihLKnx9W2oxTWjHCqtxhlDX30DmrmrpgQtD7f9Rn6DLGAyGECiE4EQ_RWdnWrGyZOEfft3vA6xi9dio5P2Jv8cbfFp0KO78_maAS4CsHCavR4JvrbntV4RApJZyzluD3vj8NPhz3Lg741qU9_uDil3lK53sfQCfV406NGsILvM5VhKLzYwq-xx_TZE7YjfhtBtUj9MCqPsLl3X2BPr263nY3xebd6zfdelPoivFU6JoxTqtSCd0aa6HVpVZcgOFUV4IZy2qrGsFKwpnaUV5zLawmttJWq7Jtygv0bJl7DP7rBDHJwUUNfa9G8FOUTLR1I9q804w-XdDPqgfpRutTUHrG5bppBWso5yRTq39Q-RgYnPYjWJf7fwXKJaCDjzGAlcfgBhVOkhI525UH-dOunO3KxW5OPbn797QbwPzO_HKZgZcLAHl73xwEGbWDvHnjZg_SePffB34AvvKz2Q</recordid><startdate>202403</startdate><enddate>202403</enddate><creator>Tran, Tao Thi</creator><creator>Gunathilake, Madhawa</creator><creator>Lee, Jeonghee</creator><creator>Oh, Jae Hwan</creator><creator>Chang, Hee Jin</creator><creator>Sohn, Dae Kyung</creator><creator>Shin, Aesun</creator><creator>Kim, Jeongseon</creator><general>Elsevier Inc</general><general>Oxford University Press</general><scope>6I.</scope><scope>AAFTH</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7X8</scope><orcidid>https://orcid.org/0000-0002-0889-2686</orcidid></search><sort><creationdate>202403</creationdate><title>The Association of Low-Carbohydrate Diet and HECTD4 rs11066280 Polymorphism with Risk of Colorectal Cancer: A Case-Control Study in Korea</title><author>Tran, Tao Thi ; Gunathilake, Madhawa ; Lee, Jeonghee ; Oh, Jae Hwan ; Chang, Hee Jin ; Sohn, Dae Kyung ; Shin, Aesun ; Kim, Jeongseon</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c426t-c5226143a9c8dffe8c3ca69ed61c492df25fa7923062ab1656c9fc0f4cfca3873</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2024</creationdate><topic>case-control study</topic><topic>Colorectal cancer</topic><topic>Genetic aspects</topic><topic>Health aspects</topic><topic>HECTD4 rs11066280</topic><topic>Korea</topic><topic>Low-carbohydrate diet</topic><topic>Physiological aspects</topic><topic>Prevention</topic><topic>Risk factors</topic><topic>Single nucleotide polymorphisms</topic><topic>Ubiquitin-proteasome system</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Tran, Tao Thi</creatorcontrib><creatorcontrib>Gunathilake, Madhawa</creatorcontrib><creatorcontrib>Lee, Jeonghee</creatorcontrib><creatorcontrib>Oh, Jae Hwan</creatorcontrib><creatorcontrib>Chang, Hee Jin</creatorcontrib><creatorcontrib>Sohn, Dae Kyung</creatorcontrib><creatorcontrib>Shin, Aesun</creatorcontrib><creatorcontrib>Kim, Jeongseon</creatorcontrib><collection>ScienceDirect Open Access Titles</collection><collection>Elsevier:ScienceDirect:Open Access</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>MEDLINE - Academic</collection><jtitle>Current developments in nutrition</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Tran, Tao Thi</au><au>Gunathilake, Madhawa</au><au>Lee, Jeonghee</au><au>Oh, Jae Hwan</au><au>Chang, Hee Jin</au><au>Sohn, Dae Kyung</au><au>Shin, Aesun</au><au>Kim, Jeongseon</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>The Association of Low-Carbohydrate Diet and HECTD4 rs11066280 Polymorphism with Risk of Colorectal Cancer: A Case-Control Study in Korea</atitle><jtitle>Current developments in nutrition</jtitle><addtitle>Curr Dev Nutr</addtitle><date>2024-03</date><risdate>2024</risdate><volume>8</volume><issue>3</issue><spage>102127</spage><epage>102127</epage><pages>102127-102127</pages><artnum>102127</artnum><issn>2475-2991</issn><eissn>2475-2991</eissn><abstract>Glucose is a main source of energy for tumor cells. Thus, a low-carbohydrate diet (LCD) is thought to make a significant contribution to cancer prevention. In addition, LCD and HECT domain E3 ubiquitin protein ligase 4 (HECTD4) gene may be related to insulin resistance.
We explored whether LCD score and HECTD4 rs11066280 are etiological factors for colorectal cancer (CRC) and whether LCD score interacts with HECTD4 rs11066280 to modify CRC risk.
We included 1457 controls and 1062 cases in a case-control study. The LCD score was computed based on the proportion of energy obtained from carbohydrate, protein, and fat, as determined by a semiquantitative food frequency questionnaire. We used unconditional logistic regression models to explore the association of HECTD4 with CRC prevention and interaction of LCD score and HECTD4 polymorphism with CRC preventability.
Individuals with AA/AT genotypes who carried a minor allele (A) of HECTD4 rs11066280 exhibited a decreased CRC risk [odds ratio (OR) = 0.75, 95% confidence interval (CI): 0.62, 0.91]. In addition, a protective effect of high LCD score against CRC development was identified (OR = 0.52, 95% CI: 0.40, 0.68, P for trend <0.001). However, the effect of LCD depended on individual’s genetic background, which appears only in participants with TT genotype of HECTD4 rs11066280 [OR = 0.49 (0.36–0.68), P interaction = 0.044].
Our findings suggest a protective effect of LCD and a minor allele of HECTD4 rs11066280 against CRC development. In addition, we provide an understanding of the interaction effect of LCD and HECTD4 rs11066280 on CRC, which may be helpful for establishing diet plans regarding cancer prevention.</abstract><cop>United States</cop><pub>Elsevier Inc</pub><pmid>38523829</pmid><doi>10.1016/j.cdnut.2024.102127</doi><tpages>1</tpages><orcidid>https://orcid.org/0000-0002-0889-2686</orcidid><oa>free_for_read</oa></addata></record> |
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| source | DOAJ Directory of Open Access Journals; Oxford Journals Open Access Collection; EZB-FREE-00999 freely available EZB journals; PubMed Central |
| subjects | case-control study Colorectal cancer Genetic aspects Health aspects HECTD4 rs11066280 Korea Low-carbohydrate diet Physiological aspects Prevention Risk factors Single nucleotide polymorphisms Ubiquitin-proteasome system |
| title | The Association of Low-Carbohydrate Diet and HECTD4 rs11066280 Polymorphism with Risk of Colorectal Cancer: A Case-Control Study in Korea |
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